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排序方式: 共有65条查询结果,搜索用时 15 毫秒
1.
2.
The preparation of a variety of 8-cyano-1,4-dihydro-7-phenyl-4-oxopyrrolo[1,2-a]pyrimidine-3-carboxylicacids and 8-cyano-1,4-dihydro-7-p-fluorophenyl-4-oxopyrrolo[1,2-a]pyrimidine-3-carboxylic acids is described. 相似文献
3.
The synthesis and selected reactions of 2-amino-3-(cyanomethylsulfonyl)thiophene is reported. In particular, cyclization reaction of the versatile aminothiophene yielded a number of novel thieno[3,2-b][1,4]-thiazine 1,1-dioxides, as well as the analogous thieno[2,3-e][1,3,4]thiadiazine 4,4-dioxide. Reaction of the thienothiazine system with hydrazine was subsequently explored, which resulted in either ring-opening of the thiazine and formation of an aminopyrazole or solely ring cleavage depending on the thiazine substituent. Additionally, the synthesis of bis(2-amino-3-thienyl)sulfone and the corresponding bis-acetamide is described. 相似文献
4.
A series of indole, thiophene and pyrrole-fused 1,3-oxazine-2,4-diones, 2-methyl-1,3-oxazin-4-ones and 2-dimethylamino-1,3-oxazin-4-ones were synthesized and evaluated as antitumor agents. 相似文献
5.
Drug binding to serum albumin influences several important pharmacological properties such as toxicity, solubility, activity, distribution, and excretion. It is therefore of interest to have methodologies that allow for the determination of drug-albumin affinity constants while simultaneously providing information on the location of the drug binding site. In the present work we describe a method for the determination of binding constants of drugs known to bind to subdomain IIIA of serum albumin. Drugs used in the study were ketoprofen, ibuprofen, quinidine, naproxen, imipramine, and clofibrate. Binding constants of the drugs were determined by near-infrared dye-displacement capillary electrophoresis. The dye-displacement technique uses a competitive-type interaction between the drug of interest and a dye probe to arrive at a binding constant. A heptamethine cyanine dye was used as a probe for drug binding at subdomain IIIA of serum albumin. The utility of the dye as a noncovalent label for serum albumin was investigated. Additionally, the ability of the method to illustrate enantioselective binding is shown. The dye displacement technique has advantages over current electrophoresis-based techniques in that it is faster and uses less reagent. 相似文献
6.
CLAUDIA L. PARKER OSCAR N. VENTURA STAN K. BURT RAÚL E. CACHAU 《Molecular physics》2013,111(17):2659-2668
We present a general purpose QM-MM-MD engine (DYNGA) designed to test alternative hybrid Hamiltonians geared towards the treatment of problems of interest in structural biology including the use of experimental data constraints. In this first presentation we use DYNGA to explore the behaviour of a traditional QM-MM approach in the treatment of the water—water interaction. We find the potential energy hypersurface for the water dimer computed with the HF 4–31G*/TIP3P hybrid Hamiltonian tends to be too flat. We also explore the effect of using traditional QM-MM techniques on proton wires and conclude there is a need for improvement, possibly addressed by using polarizable force fields. 相似文献
7.
Said M. Bayomi Kenneth E. Price J. Walter Sowell 《Journal of heterocyclic chemistry》1985,22(1):83-88
A route for the synthesis of various derivatives of 7-oxopyrrolo[3,2-b]pyridine-6-carboxylic acid from 2-methyl-3-carbomethoxy-4-aminopyrrole is reported. 相似文献
8.
W. N. Mei G. Sowell 《International Journal of Mathematical Education in Science & Technology》2013,44(2):189-207
Applying the commonly used partial wave method in the quantum theory of collisions, the scattering cross-sections of the two- and three-dimensional attractive and repulsive potentials are expressed as sums of phase shifts. With the help of the Maple software program, the phase shifts and cross-sections are plotted as functions of the kinetic energy and potential height, and it is demonstrated that the systematic convergence of the cross-sections as higher angular-momentum phase shifts are included in the summations. It is found that the cross-sections of the attractive potential oscillate with both the kinetic energy and the potential strength, even though the phase shifts are monotonic. It is also shown that in the case of the repulsive potential, both the phase shifts and cross-sections change profoundly when the kinetic energy of the incident particle is lower than the potential height. 相似文献
9.
A newly developed interface coupling a CHN combustion device (elemental analyser 'EA') to an isotope ratio mass spectrometer is described and evaluated. The purpose of the device is to extend the dynamic range of delta(13)C and delta(15)N analysis from less than 2 orders of magnitude to more than 3 orders of magnitude. Carbon isotope ratio measurements of atropine as a model compound have been performed analysing between 1 μg to 5 mg C with acceptable to excellent precision (0.6 to 0.06 per thousand, delta-notation). The correction due to the blank signal is critical for sample amounts smaller than 4 μg C. The maximum sample weight is determined by the combustion capacity of the EA. Larger sample amounts are measured using dilution of a small part of the EA effluent with helium. The dilution mechanism works virtually free of isotope fractionation. Copyright 1999 John Wiley & Sons, Ltd. 相似文献
10.
Sandra Rae Etson Ronald J. Mattson J. Walter Sowell 《Journal of heterocyclic chemistry》1979,16(5):929-933
A facile route for the synthesis of substituted pyrrolo[2,3-d]pyrimidine-2,4-diones from substituted 2-amino-3-cyano-4-methylpyrroles is reported. 相似文献