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Namita Singh Sana Ahmed Aliyah Fakim Somayah Qutub Othman Alahmed Omar El Tall Osama Shekhah Mohamed Eddaoudi Niveen M. Khashab 《Chemical science》2020,11(41):11280
Assembling well-defined MOF superstructures remains challenging as it requires easily removable hard templates or readily available immiscible solutions for an emulsion-based soft-template approach. In this work, a single-step emulsion-free soft templating approach is reported to spontaneously prepare hollow ZIF-8 and ZIF-67 colloidosomes with no further purification. These superstructures can load different enzymes regardless of the size and charge with a high encapsulation efficiency of 99%. We envisage that this work will expand the repertoires of MOF superstructures by the judicious selection of precursors and the reaction medium.An emulsion-free approach for the preparation of hollow ZIF-8 superstructures in a single step is established based on metal sulfate hydrates in methanol. 相似文献
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RM Schweller J Zimak DY Duose AA Qutub WN Hittelman MR Diehl 《Angewandte Chemie (International ed. in English)》2012,51(37):9292-9296
DNA-based erasers: The designed strand-displacement reactions between dynamic DNA probes (carrying fluorescent dyes () and quencher domains (?)) and DNA-antibody conjugates generate detachable immunofluoresence-reporting complexes that can be assembled (first image) and disassembled (second image) reversibly within fixed cells. With this system, different protein targets can be imaged sequentially within the same cells (third image). 相似文献
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Back Cover: Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins (Angew. Chem. Int. Ed. 43/2015) 下载免费PDF全文
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Discovery of a Single Monooxygenase that Catalyzes Carbamate Formation and Ring Contraction in the Biosynthesis of the Legonmycins 下载免费PDF全文
Sheng Huang Dr. Jioji Tabudravu Somayah S. Elsayed Jeanne Travert Doe Peace Ming Him Tong Dr. Kwaku Kyeremeh Dr. Sharon M. Kelly Dr. Laurent Trembleau Dr. Rainer Ebel Prof. Dr. Marcel Jaspars Dr. Yi Yu Dr. Hai Deng 《Angewandte Chemie (International ed. in English)》2015,54(43):12697-12701
Pyrrolizidine alkaloids (PAs) are a group of natural products with important biological activities. The discovery and characterization of the multifunctional FAD‐dependent enzyme LgnC is now described. The enzyme is shown to convert indolizidine intermediates into pyrrolizidines through an unusual ring expansion/contraction mechanism, and catalyze the biosynthesis of new bacterial PAs, the so‐called legonmycins. By genome‐driven analysis, heterologous expression, and gene inactivation, the legonmycins were also shown to originate from non‐ribosomal peptide synthetases (NRPSs). The biosynthetic origin of bacterial PAs has thus been disclosed for the first time. 相似文献
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Walaa S. Baslyman Dr. Othman Alahmed Dr. Santanu Chand Somayah Qutub Prof. Niveen M. Khashab 《Angewandte Chemie (International ed. in English)》2023,62(25):e202302840
Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics. 相似文献
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