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排序方式: 共有1481条查询结果,搜索用时 15 毫秒
1.
Farsi R. Mohammadi M. K. Saghanezhad S. J. 《Russian Journal of Organic Chemistry》2021,57(12):2002-2009
Russian Journal of Organic Chemistry - Herein, we report the sulfonamide-functionalized covalent organic framework (COF-SO3H), prepared by condensation of melamine and terephthalaldehyde and... 相似文献
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Md. Zia Uddin Arkajyoti Paul Ahmed Rakib Saad Ahmed Sami Shafi Mahmud Md. Sohel Rana Shahadat Hossain Abu Montakim Tareq Mycal Dutta Talha Bin Emran Jesus Simal-Gandara 《Molecules (Basel, Switzerland)》2021,26(4)
The current study attempted, for the first time, to qualitatively and quantitatively determine the phytochemical components of Elatostema papillosum methanol extract and their biological activities. The present study represents an effort to correlate our previously reported biological activities with a computational study, including molecular docking, and ADME/T (absorption, distribution, metabolism, and excretion/toxicity) analyses, to identify the phytochemicals that are potentially responsible for the antioxidant, antidepressant, anxiolytic, analgesic, and anti-inflammatory activities of this plant. In the gas chromatography-mass spectroscopy analysis, a total of 24 compounds were identified, seven of which were documented as being bioactive based on their binding affinities. These seven were subjected to molecular docking studies that were correlated with the pharmacological outcomes. Additionally, the ADME/T properties of these compounds were evaluated to determine their drug-like properties and toxicity levels. The seven selected, isolated compounds displayed favorable binding affinities to potassium channels, human serotonin receptor, cyclooxygenase-1 (COX-1), COX-2, nuclear factor (NF)-κB, and human peroxiredoxin 5 receptor proteins. Phytol acetate, and terpene compounds identified in E. papillosum displayed strong predictive binding affinities towards the human serotonin receptor. Furthermore, 3-trifluoroacetoxypentadecane showed a significant binding affinity for the KcsA potassium channel. Eicosanal showed the highest predicted binding affinity towards the human peroxiredoxin 5 receptor. All of these findings support the observed in vivo antidepressant and anxiolytic effects and the in vitro antioxidant effects observed for this extract. The identified compounds from E. papillosum showed the lowest binding affinities towards COX-1, COX-2, and NF-κB receptors, which indicated the inconsequential impacts of this extract against the activities of these three proteins. Overall, E. papillosum appears to be bioactive and could represent a potential source for the development of alternative medicines; however, further analytical experiments remain necessary. 相似文献
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Briana L. Simms Nan Ji Indika Chandrasiri Mohammad Farid Zia Chinwe S. Udemgba Ravinder Kaur Jared H. Delcamp Alex Flynt Chalet Tan Davita L. Watkins 《Journal of polymer science. Part A, Polymer chemistry》2021,59(19):2177-2192
Here, we demonstrate the applicability of self-assembling linear-dendritic block copolymers (LDBCs) and their nanoaggregates possessing varied surfaces as therapeutic nanocarriers. These LDBCs are comprised of a hydrophobic, linear polyester chemically coupled to a hydrophilic dendron polyamidoamine (PAMAM)—the latter of which acts as the surface of the self-assembled nanoaggregate in aqueous media. To better understand how surface charge density affects the overall operability of these nanomaterials, we modified the nanoaggregate surface to yield cationic (NH3+), neutral (OH), and anionic (COO−) surfaces. The effect of these modifications on the physicochemical properties (i.e., size, morphology, and surface charge density), colloidal stability, and cellular uptake mechanism of the polymeric nanocarrier were investigated. This comparative study demonstrates the viability of nanoaggregates formed from PDLLA-PAMAM LDBCs to serve as nanocarriers for applications in drug delivery. 相似文献
5.
Summary The main purpose of this paper is to introduce the concepts of η-sets, ηζ-sets,η-continuity and ηζ-continuity and to obtain
a decomposition of continuity. 相似文献
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Hadi Mohammadi Bidhandi 《Annals of Operations Research》2006,143(1):237-250
This paper develops a mathematical model for project time compression problems in CPM/PERT type networks. It is noted this
formulation of the problem will be an adequate approximation for solving the time compression problem with any continuous
and non-increasing time-cost curve. The kind of this model is Mixed Integer Linear Program (MILP) with zero-one variables,
and the Benders' decomposition procedure for analyzing this model has been developed. Then this paper proposes a new approach
based on the surrogating method for solving these problems. In addition, the required computer programs have been prepared
by the author to execute the algorithm. An illustrative example solved by the new algorithm, and two methods are compared
by several numerical examples. Computational experience with these data shows the superiority of the new approach. 相似文献
8.
Pre—Separation Axioms in Fuzzifying Topology 总被引:1,自引:0,他引:1
K.M.AbdEl-Hakeim F.M.Zeyada 《模糊系统与数学》2003,17(1):28-36
1 IntroductionYing[5,6 ] introduced and elementally developed so called fuzzifying topology with the semanticmethod of continuous valued L ogic.Shen[7] introduced and studied T0 -,T1-,T2 (Hausdorff) -,T3(regularity) -,T4 (normality) -separation axioms in fuzzifying topology.In [3 ]the concepts of thefamily of fuzzifying pre-open sets,fuzzifying pre-neighbourhood structure of a point and fuzzifyingpre-closure are introduced and studied.It is worth to mention that pre-separation axioms are … 相似文献
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B. Ivorra A. M. Ramos B. Mohammadi 《Journal of Optimization Theory and Applications》2007,135(3):549-561
This paper has two objectives. We introduce a new global optimization algorithm reformulating optimization problems in terms
of boundary-value problems. Then, we apply this algorithm to a pointwise control problem of the viscous Burgers equation,
where the control weight coefficient is progressively decreased. The results are compared with those obtained with a genetic
algorithm and an LM-BFGS algorithm in order to check the efficiency of our method and the necessity of using global optimization
techniques. 相似文献