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Sathiah Thennarasu 《Tetrahedron letters》2010,51(24):3218-3220
The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safety-catch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions. 相似文献
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18‐Crown‐6 Catalyzed Microwave‐mediated Synthesis of Symmetric Bis‐Heterocyclic Compounds under Solvent‐free Condition 下载免费PDF全文
Rathnasamy Rishikesan Kamalakannan Prabakaran Rajamani Murugesan Ramaswamy Venkataraman Pakkath Karuvalam Ranjith Sivasubramanian Arvind Sathiah Thennarasu 《Journal of heterocyclic chemistry》2015,52(5):1321-1330
An efficient, solvent‐free and 18‐crown‐6 catalyzed method for the synthesis of N‐alkyl‐4‐(4‐(5‐(2‐(alkyl‐amino)thiazol‐4‐yl)pyridin‐3‐yl)phenyl)thiazol‐2‐amine, N‐alkyl‐4‐(5‐(2‐alkyamino)thiazol‐4‐yl)pyridine‐3‐yl)thiazol‐2‐amine, and 4,4′‐bis‐{2‐[amino]‐4‐thiazolyl}biphenyl bis‐heterocyclic derivatives via microwave accelerated cyclization is presented. 相似文献
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Ashoke De Ernst Oldenhof Pratap Sathiah Dirk Roekaerts 《Flow, Turbulence and Combustion》2011,87(4):537-567
In this paper, we report results of a numerical investigation of turbulent natural gas combustion for a jet in a coflow of
lean combustion products in the Delft-Jet-in-Hot-Coflow (DJHC) burner which emulates MILD (Moderate and Intense Low Oxygen
Dilution) combustion behavior. The focus is on assessing the performance of the Eddy Dissipation Concept (EDC) model in combination
with two-equation turbulence models and chemical kinetic schemes for about 20 species (Correa mechanism and DRM19 mechanism)
by comparing predictions with experimental measurements. We study two different flame conditions corresponding to two different
oxygen levels (7.6% and 10.9% by mass) in the hot coflow, and for two jet Reynolds number (Re = 4,100 and Re = 8,800). The
mean velocity and turbulent kinetic energy predicted by different turbulence models are in good agreement with data without
exhibiting large differences among the model predictions. The realizable k-ε model exhibits better performance in the prediction of entrainment. The EDC combustion model predicts too early ignition
leading to a peak in the radial mean temperature profile at too low axial distance. However the model correctly predicts the
experimentally observed decreasing trend of lift-off height with jet Reynolds number. A detailed analysis of the mean reaction
rate of the EDC model is made and as possible cause for the deviations between model predictions and experiments a low turbulent
Reynolds number effect is identified. Using modified EDC model constants prediction of too early ignition can be avoided.
The results are weakly sensitive to the sub-model for laminar viscosity and laminar diffusion fluxes. 相似文献
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Saijyothi AV Angayarkanni N Syama C Utpal T Shweta A Bhaskar S Geetha IK Vinay PS Thennarasu M Sivakumar RM Prema P 《Electrophoresis》2010,31(20):3420-3427
Tear proteomics, by 2-DE, can give a fingerprint of the protein profile, which is well suited in clinical proteomics for biomarker identification and in diagnostics. The mode of tear collection can influence the representation of the proteins in the tear and therefore it is important to use the appropriate method. In this study, capillary and Schirmer mode of tear collection was done in the healthy controls and the Schirmer method was validated in dry eye syndrome conditions. 2-D PAGE of normal and dry eye tear was performed using pH 3-10 linear IPG strips followed by 13% SDS-PAGE. The spot intensity was analyzed by the PD quest software. The two methods were compared using Bland-Altman statistical tool. The 2-D map of capillary and Schirmer tear showed 147 ± 8 spots and 145 ± 7 spots respectively. Both the collection methods were in agreement with each other and were comparable. Dry eye tear protein showed differential expression of proteins as observed in 25-35 kDa region. One of the significantly reduced protein was identified as proline-rich 4 protein. Schirmer method of tear collection is reliable in patients with dry eye, which can display the differential protein expression and help in biomarker identification. 相似文献
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A new series of bis- and tris-spirooxindole derivatives have been synthesized by controlling the molar equivalent of in situ generated azomethine ylides in [3+2]-cycloaddition reactions with dipolarophiles. The structural elucidation on the basis of IR, 1H NMR, 13C NMR, and mass spectral data of these compounds established the highly chemoselective and regioselective formation of spirooxindole derivatives. Single crystal X-ray analysis of compound 4g and 2D NMR analysis of compound 5a confirmed the structures of bis- and tris-spirooxindole derivatives. 相似文献
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The regioselective synthesis of a series of novel dispiropyrrolidines and dispiropyrrolizidines has been accomplished through intermolecular 1,3-dipolar cycloaddition of azomethine ylides obtained from 1,2-diones like isatin and acenaphthenequinone with acenaphthenone-2-ylidine ketone dipolarophiles in methanol under reflux conditions. 相似文献
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G. Saberwal S. Thennarasu V. M. Dhople M. V. Jagannadham R. Nagaraj 《Journal of Chemical Sciences》1994,106(5):1109-1121
Studies in our laboratory have been directed towards understanding the mechanism of action of two hydrophobic toxins, pardaxin
comprising 33 residues and δ-toxin comprising 26 residues. Since isolation of these peptides in large amounts from natural
sources is not convenient, we have explored synthetic approaches to get these peptides as well as their analogs. We have used
chemistry specific to fluorenylmethoxycarbonyl (Fmoc) andt-butyloxycarbonyl (Boc) amino acids. Synthesis specific for Fmoc amino acids was carried out manually as well as on a semi-automated
continuous flow peptide synthesizer. Synthesis specific for Boc amino acids was carried out manually. The protocols used by
us have yielded 15–33 residue peptides which are of high purity. Even in peptides where heterogeneity was present, pure peptide
could be obtained in good yields using simple gradients in fast performance liquid chromatography. The synthesis of pardaxin,
δ-toxin and several analogs should help in identifying the molecular determinants of biological activity. 相似文献
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NR Chereddy S Thennarasu AB Mandal 《Dalton transactions (Cambridge, England : 2003)》2012,41(38):11753-11759
Two new rhodamine based probes 1 and 2 for the detection of Fe(3+) were synthesized and their selectivity towards Fe(3+) ions in the presence of other competitive metal ions tested. The probe 1 formed a coloured complex with Fe(3+) as well as Cu(2+) ions and revealed the lack of adequate number of coordination sites for selective complexation with Fe(3+). Incorporation of a triazole unit to the chelating moiety of 1 resulted in the probe 2, that displayed Fe(3+) selective complex formation even in the presence of other competitive metal ions like Li(+), Na(+), K(+), Cu(2+), Mg(2+), Ca(2+), Sr(2+), Cr(3+), Mn(2+), Fe(2+), Co(2+), Ni(2+), Zn(2+), Cd(2+), Hg(2+) and Pb(2+). The observed limit of detection of Fe(3+) ions (5 × 10(-8) M) confirmed the very high sensitivity of 2. The excellent stability of 2 in physiological pH conditions, non-interference of amino acids, blood serum and bovine serum albumin (BSA) in the detection process, and the remarkable selectivity for Fe(3+) ions permitted the use of 2 in the imaging of live fibroblast cells treated with Fe(3+) ions. 相似文献
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