排序方式: 共有6条查询结果,搜索用时 0 毫秒
1
1.
Saraya Roshdy E. Hassan Yasser F. Eltukhi Walid E. Salman Baher I. 《Journal of fluorescence》2022,32(5):1725-1732
Journal of Fluorescence - Vonoprazan (VON) has been approved recently via US-FDA in 2015 as the first in class of potassium competitive acid blocker group. VON is used for management of... 相似文献
2.
JPC – Journal of Planar Chromatography – Modern TLC - A rapid, sensitive, and eco-friendly micellar high-performance thin-layer chromatography (HPTLC) technique for the simultaneous... 相似文献
3.
Roshdy E. Saraya Sami El Deeb Baher I. Salman Adel Ehab Ibrahim 《Journal of separation science》2022,45(14):2582-2590
Favipiravir, molnupiravir, and ritonavir have been recently approved as the first oral antivirals for treatment of SARS-CoV-2 viral infections. Their combination was reported in several clinical studies, alternatively, to enhance the viral eradication and improve patient's recovery times and rates. Being all orally administered, therefore, the development of new sensitive and validated methodologies for their simultaneous determination is a necessitate. In the proposed research, a sensitive, selective, and simple high-performance thin layer chromatography method was developed and validated for determination of favipiravir, molnupiravir, and ritonavir. Silica gel 60F254 thin layer chromatography plates were used as stationary phase for this separation using mobile phase composed of methylene chloride:ethyl acetate:methanol:25% ammonia (6:3:4:1, v/v/v/v). Densitometric detection was performed at wavelength 289 nm. Peaks of favipiravir, molnupiravir, and ritonavir were resolved at retention factors 0.22, 0.42, and 0.63, respectively. The proposed method was found linear within the specified ranges of 3.75–100.00 μg/mL for molnupiravir and favipiravir, and 2.75–100.00 μg/mL for ritonavir. Limits of detection were found to be 1.12, 1.21, and 0.89 μg/mL for favipiravir, molnupiravir, and ritonavir, respectively. This is the first method to be reported for the simultaneous determination of the cited three antiviral drugs. The method was assessed on novel greenness metrics. 相似文献
4.
JPC – Journal of Planar Chromatography – Modern TLC - The therapeutic combination of ondansetron (OND) and pantoprazole (PAN) is widely prescribed for the treatment of many... 相似文献
5.
JPC – Journal of Planar Chromatography – Modern TLC - The discovery of new direct-acting antiviral drugs gave rise to a leap forward in the treatment of hepatitis C viral infections.... 相似文献
6.
1