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Ratchanaporn Chokchaisiri Waraluck Chaichompoo Oratai Sukcharoen Apichart Suksamrarn Lucksagoon Ganranoo 《Natural product research》2019,33(20):2890-2896
The diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3β-hydroxyisocoronarin D (2), 6α-hydroxyisocoronarin D (3) and 3β,7α-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.
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Praphakorn Kaemchantuek Ratchanaporn Chokchaisiri Samran Prabpai Palangpon Kongsaeree Warangkana Chunglok Tanyarath Utaipan Walee Chamulitrat Apichart Suksamrarn 《Tetrahedron》2017,73(12):1594-1601
Phytochemical investigation of Trigonostemon reidioides roots led to the isolation of fourteen compounds. These included six new diterpenoids, trigonoreidons A?F (1?6), together with eight known diterpenoids 7?14. The structures of the new compounds were elucidated by spectroscopic techniques and the absolute configuration at the asymmetric carbon was determined by the modified Mosher's method. The structure of trigonoreidon B (2) was confirmed by X-ray crystallographic analysis. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated compounds were evaluated for antimycobacterial activity against Mycobacterium tuberculosis. Among the compounds that exhibited antimycobacterial activity, the diterpenoids rediocide C (12) and rediocide G (14) were the most active compounds, with the MIC value of 3.84 μM. 相似文献
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Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids 总被引:1,自引:0,他引:1
Tanachatchairatana T Bremner JB Chokchaisiri R Suksamrarn A 《Chemical & pharmaceutical bulletin》2008,56(2):194-198
Betulinic acid, oleanolic acid and ursolic acid have been modified at the C-3 position to cinnamate-based esters and in vitro antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra has been determined. The results indicated that modification of the parent structures of betulinic acid, oleanolic acid and ursolic acid to the p-coumarate and, in the case of the latter two triterpenes, the ferulate ester analogues resulted in high antimycobacterial activity. Structure-activity relationships within the lupane, oleanane and ursane analogues and between these triterpenes are discussed. 相似文献
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