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1.
An expedient procedure for the acylation of alcohols, phenols, and thiophenols using catalytic amount of Zn(OTf)2 is described. This procedure is highly suitable for industrial application due to use of less toxic metal as a part of catalyst, short reaction time at ambient temperature, without any racemization of chiral alcohols. 相似文献
2.
Manne Naga RajuNeelam Uday Kumar Baddam Sudhakar ReddyNaredla Anitha Gangula SrinivasApurba Bhattacharya Kagga MukkantiNaveenkumar Kolla Rakeshwar Bandichhor 《Tetrahedron letters》2011,52(42):5464-5466
An alternative and scalable synthesis of dexlansoprazole ((R)-(+)-1); the (R)-enantiomer of Lansoprazole with an enantiomeric excess of >99.8% is presented. 相似文献
3.
Two methods are presented that were designed to circumvent the persistent problem of benzofuran formation and instead yield a spiroketal of the rubromycin family type. First, using an alternative disconnection, a hemiketal conjugate addition to a naphthaquinone electrophile was investigated. Synthesis of the requisite electrophile provided insight into the selective oxidation and functionalization of the naphthalene portion. Second, the electronic features of the isocoumarin ring system were adjusted, and the corresponding reactivity further supports the hypothesis that electron-rich isocoumarins are capable of spiroketalization. Robust, flexible syntheses from simple precursors were developed that allowed multiple reduced isocoumarins to be generated. Combined, the data presented herein give insight into the sensitivities of this family and illuminate other potential methods of spiroketalization. In addition, the convergent assembly of substrates containing different naphthaquinone and isocoumarin subunits highlights the utility of our 1,3-dipolar cycloaddition approach to generate analogs of these structures for SAR, as well as chemical reactivity studies. 相似文献
4.
Kotagiri Vijay Kumar Jambula mukunda Reddy Sashi Kanth Suthrapu Chitneni Prasad Rao P. Pratap Reddy Apurba Bhattacharya Rakeshwar Bandichhor 《Monatshefte für Chemie / Chemical Monthly》2008,139(9):1091-1093
A novel synthesis route for a rimonabant regioisomer was developed.
Correspondence: Rakeshwar Bandichhor, Innovation Plaza, IPD, R&D, Dr. Reddy’s Laboratories Ltd., Survey Nos. 42, 45, 46 &
54, Bachupally, Qutubullapur, R. R. Dist. 500073, A.P., India; Chitneni Prasad Rao, Department of Chemistry, Osmania University,
Hyderabad 5000007, A.P., India. 相似文献
5.
Bhaskar Kandagatla Vetukuri Venkata Naga Kali Vara Prasada Raju Ganta Madhusudhan Reddy Sirigiri Chandrakanth Rao Javed Iqbal Rakeshwar Bandichhor Srinivas Oruganti 《Tetrahedron letters》2012,53(52):7125-7127
Agomelatine was synthesized from 8-aminonaphthalen-2-ol by diazotization-iodination, formylation, C–C bond formation by nitroaldol and Pd/C hydrogenation of β-nitrovinylnaphthalene followed by N-acetylation. The route reported employs readily and commercially viable starting materials and reagents, and can potentially be utilized for process synthesis of agomelatine. 相似文献
6.
Satish Kumar Vujjini V.R. Krishnam Raju Datla Krishna Rao Badarla V.N.K.V. Prasada Raju Vetukuri Rakeshwar Bandichhor Mukkanti Kagga Praveen Cherukupally 《Tetrahedron letters》2014
Total synthesis of antidepressant drug, agomelatine is reported. Regio selective Friedel–Crafts acylation followed by Willgerodt–Kindler reactions is used as the key steps for the synthesis of agomelatine. 相似文献
7.
Lipid diffusion from single molecules of a labeled protein undergoing dynamic association with giant unilamellar vesicles and supported bilayers 总被引:1,自引:0,他引:1
Sharonov A Bandichhor R Burgess K Petrescu AD Schroeder F Kier AB Hochstrasser RM 《Langmuir : the ACS journal of surfaces and colloids》2008,24(3):844-850
It is demonstrated that single-molecule tracking of a fluorescently labeled protein undergoing transient binding to model membranes presents a useful method of obtaining fluid properties. The labeled ACBP protein was tracked during its binding to free-standing giant unilamellar vesicles (GUVs) and supported bilayers prepared from the GUVs in the same environment. The analysis of images that are blurred as a result of fast probe diffusion was discussed. An examination of the lateral diffusion trajectories revealed a homogeneous diffusion on the top segments of the GUVs with D = 6.9 +/- 0.3 microm(2)/s. The supported bilayer experiments revealed two diffusion processes, one with Df = 3.1 +/- 0.4 microm(2)/s and the other with Ds = 0.078 +/- 0.001 microm(2)/s. The 2-fold difference in the lipid bilayer mobility for the free-standing and fast components in the supported bilayers is attributed to the known effect of frictional coupling with the solid support. The slow mobile fraction in the bilayer is suggested to be associated with the migration of pore-like structures, originating from the interaction of the membrane with the glass support. 相似文献
8.
9.
Pallavi ThakurB. Kumaraswamy G. Raji ReddyRakeshwar Bandichhor K. Mukkanti 《Tetrahedron letters》2012,53(29):3703-3705
The first stereoselective total synthesis of polyacetylene panaxjapyne C is described. The key reactions include regioselective opening of the epoxide and Cadiot-Chodkiewicz cross-coupling reactions. l-Ascorbic acid was used as a chiral pool material for the construction of the both terminal acetylenes. 相似文献
10.
[reaction: see text] Bicyclic and tricyclic gamma-butyrolactones with 5,7-, 5,6,5-, 5,6,6-, or 5,7,5-fused ring systems, being found in xanthanolides, eudesmanolides, and guaianolides, were readily synthesized from methyl furan-2-carboxylic acid. Key steps were a copper(I)-catalyzed asymmetric cyclopropanation, Sakurai allylations, intramolecular ene reactions, and ring-closing metathesis reactions. 相似文献