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Shannon R. Fix-Stenzel Xiaolei Zhang Pintipa Grongsaard Steven M. Hannick Robert H. Stoffel 《Tetrahedron letters》2009,50(28):4081-2250
A scalable and enantioselective synthesis of a potent S1P1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the absolute chirality of an amino alcohol precursor, generated via a robust phase-transfer catalyzed alkylation protocol, allows for substrate directed hydrogenation to install the second stereogenic center providing access to gram-quantities of compound 2. 相似文献
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