排序方式: 共有38条查询结果,搜索用时 15 毫秒
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Congjun Yu Bünyamin Özkaya Prof. Dr. Frederic W. Patureau 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(11):3682-3687
A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool. 相似文献
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Vinzenz Thönnißen Prof. Dr. Frederic W. Patureau 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(25):7189-7192
The atroposelective formation of C−N bonds has recently emerged within the field of amination reactions. On first sight, it may seem quite surprising that such an ancient class of organic coupling reactions (Gabriel, Ullmann, Goldberg, Buchwald, Hartwig and many others) has so few enantioselective solutions, and this in spite of asymmetric synthesis being now a mature concept and field. Why should enantioselective C−N bond formation be so difficult? This question and some of the first examples that promise an imminent change of paradigm are herein discussed. 相似文献
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Raolin Huang Prof. Dr. Frederic W. Patureau 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(70):e202202135
A facile and environmentally friendly electrochemical protocol is herein reported for the C(sp2)−C(sp3) cross dehydrogenative coupling between imidazopyridines and N,N-dimethylanilines. The broad functional group compatibility includes halogens, ester, alcohol, sulfone as well as thiophene. This methodology is also suitable for benzo[d]imidazo[2,1-b]thiazole, thiazoimidazole and tetrahydroisoquinoline, and can be scaled up to 5 mmol. Mechanistic insights are discussed. 相似文献
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Marie‐Laure Louillat‐Habermeyer Rongwei Jin Prof. Dr. Frederic W. Patureau 《Angewandte Chemie (International ed. in English)》2015,54(13):4102-4104
A method was developed for the direct dehydrogenative construction of C? N bonds between unprotected phenols and a series of cyclic anilines without resorting to any kind of metal activation of either substrate and without the use of halides. The resulting process relies on the exclusively organic activation of molecular oxygen and the subsequent oxidation of the aniline substrate. This allows the coupling of ubiquitous phenols, thus furnishing aminophenols through an atom‐economical and most sustainable dehydrogenative amination method. This new reactivity, which relies on the intrinsic organic reactivity of cumene in what can be seen as a modified Hock activation process of oxygen, is expected to have a large impact on the formation of C? N bonds in organic synthesis. 相似文献
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A Rh catalyzed, no-chelate-assisted C-H activation/oxidative olefination reaction of bromoarenes has been discovered, in which the latter ones seem to act as a substrate, terminal oxidant, and catalyst modifier. 相似文献
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