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1.
M Uchida S Morita M Chihiro T Kanbe K Yamasaki Y Yabuuchi K Nakagawa 《Chemical & pharmaceutical bulletin》1989,37(6):1517-1523
Many 8-[(2-benzimidazolyl)sulfinyl]-5,6,7,8-tetrahydroquinolines were synthesized and examined for their (H+ + K+) adenosine triphosphatase ATPase-inhibitory and antisecretory activities. These sulfinyl compounds could be considered to be rigid analogues of the 2-[(2-pyridyl)methylsulfinyl]benzimidazole class of antisecretory agents. All the compounds tested were potent inhibitors of (H+ + K+)ATPase. Most of the compounds also inhibited histamine-induced gastric acid secretion in rats. Among them, 8-[(5-fluoro-2-benzimidazolyl)sulfinyl]-3-methyl-5,6,7,8-tetrahydroqu inoline (XIVm) was found to have the most potent activity. The structure-activity relationships are discussed. 相似文献
2.
Yabuuchi N Yamakawa Y Yoshii K Komaba S 《Dalton transactions (Cambridge, England : 2003)》2011,40(9):1846-1848
A nearly single-phase of a low-temperature (LT) phase of Li(2)FeSiO(4) is prepared by a hydrothermal method at 150 °C. We report the detailed crystal structure of LT-Li(2)FeSiO(4) (S.G. Pmn2(1)) by applying Rietveld/MEM analysis to the synchrotron XRD pattern. LT-Li(2)FeSiO(4) shows 150 mA h g(-1) as the positive electrode materials of rechargeable batteries. 相似文献
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Hiroshi Kageyama Takashi Watanabe Yoshihiro Tsujimoto Atsushi Kitada Yuji Sumida Kazuyoshi Kanamori Kazuyoshi Yoshimura Naoaki Hayashi Shigetoshi Muranaka Mikio Takano Monica Ceretti Werner Paulus Clemens Ritter Gilles Andr 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2008,120(31):5824-5829
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High-pressure phases IV and V of calcium discovered in 2005 have the highest superconducting transition temperature of 25 K among all the elements; however, their crystal structures have not been determined. From the x-ray powder diffraction data, both Ca IV and V have been found to form unique and complex structures with a coordination number of 7. They were confirmed to be identical to the theoretical models that were recently predicted [Ishikawa, Phys. Rev. B 77 020101(R) (2008)]. 相似文献
7.
Hidekazu Miyaji Haruka Komada Keisuke Goto Junko Fujimoto Naoaki Kiriyama James H.R. Tucker 《Tetrahedron letters》2018,59(43):3853-3857
A redox-active ferrocene-based heteroditopic receptor bearing a boronic acid (as a catechol recognition site) and a benzo-18-crown-6-ether unit (as an ammonium ion recognition site) was synthesized. A 1:1 ditopic complex with dopamine was evidenced by mass spectrometry and NMR spectroscopy. Cyclic voltammetry measurements on the receptor in the presence of a series of organic guest species demonstrated the successful electrochemical sensing of dopamine through a distinct change in the ferrocene-centred redox-couple upon complex formation. 相似文献
8.
Murao N Ishigai M Yasuno H Shimonaka Y Aso Y 《Rapid communications in mass spectrometry : RCM》2007,21(24):4033-4038
A simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) method has been developed for the quantification of bioactive peptides in biological fluids. The method employs protein precipitation with 4% trichloroacetic acid (TCA) and selected reaction monitoring (SRM) using an immonium ion as the product ion. This method was applied to determine the synthetic parathyroid hormone (PTH) analog (MW 1721) in rat plasma and human hepcidin-25 (MW 2789) in human serum. TCA clean-up showed a sufficient recovery for peptides with a MW of less than 3000, and would be useful as a simple and rapid method because of direct injection of the supernatant without evaporation or dilution. In addition, TCA clean-up allowed us not only to reduce sample preparation time, but also to select an immonium ion as a product ion of SRM, which led to detection more sensitive than SRM using other types of product ions. The lower limits of quantitation (LLOQs) of the PTH analog and the human hepcidin-25 were 0.2 ng/mL and 5 ng/mL, respectively. This method was fully validated with acceptable linearity, intra- and inter-assay precisions, and accuracy. Furthermore, this simple and rapid method is applicable to pharmacokinetic studies. 相似文献
9.
Usui S Fujieda H Suzuki T Yoshida N Nakagawa H Ogura M Makishima M Miyata N 《Chemical & pharmaceutical bulletin》2007,55(7):1053-1059
To find novel PPAR ligands, we prepared several 3-{3 or 4-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}propanoic acid derivatives which were designed based on the structure of our previous PPARgamma ligand 1. In PPAR binding affinity assays, compound 4, which had an ethoxy group at the C-2 position of the propanoic acid of 1, showed selective binding affinity for PPARgamma. Compound 3, with an ethyl group at the C-2 position, was found to be a PPARalpha/gamma dual ligand. Compound 6, the meta isomer of 1, has been shown to be a PPARalpha ligand. The introduction of methyl (7) and ethyl (8) groups to the C-2 position of the propanoic acid of 6 further improved PPARalpha-binding potency. In cell-based transactivation assay, compounds 3 and 4 showed dual-agonist activity toward PPARalpha and PPARgamma. Compound 6 was found to be a triple agonist and compound 8 proved to be a selective PPARalpha agonist. In the human hypodermic preadipocyte differentiation test, it was demonstrated that the maximal activity of compounds 3 and 4 was higher than that of rosiglitazone. 相似文献
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