排序方式: 共有28条查询结果,搜索用时 31 毫秒
1.
Nadjib Bouzar 《Annals of the Institute of Statistical Mathematics》2004,56(3):497-510
The purpose of this paper is to introduce and study the concepts of discrete semi-stability and geometric semi-stability for
distributions with support inZ
+. We offer several properties, including characterizations, of discrete semi-stable distributions. We establish that these
distributions posses the property of infinite divisibility and that their probability generating functions admit canonical
representations that are analogous to those of their continuous counterparts. Properties of discrete geometric semi-stable
distributions are deduced from the results obtained for discrete semi-stability. Several limit theorems are established and
some examples are constructed. 相似文献
2.
Andreea L. Turcu Antoine Versini Nadjib Khene Christine Gaillet Dr. Tatiana Cañeque Dr. Sebastian Müller Dr. Raphaël Rodriguez 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(33):7369-7373
Cancer stem cells (CSC) constitute a cell subpopulation in solid tumors that is responsible for resistance to conventional chemotherapy, metastasis and cancer relapse. The natural product Salinomycin can selectively target this cell niche by directly interacting with lysosomal iron, taking advantage of upregulated iron homeostasis in CSC. Here, inhibitors of the divalent metal transporter 1 (DMT1) have been identified that selectively target CSC by blocking lysosomal iron translocation. This leads to lysosomal iron accumulation, production of reactive oxygen species and cell death with features of ferroptosis. DMT1 inhibitors selectively target CSC in primary cancer cells and circulating tumor cells, demonstrating the physiological relevance of this strategy. Taken together, this opens up opportunities to tackle unmet needs in anti-cancer therapy. 相似文献
3.
4.
Nadjib Brahimi Sharfuddin A. Khan 《4OR: A Quarterly Journal of Operations Research》2014,12(2):175-197
In this paper, a supply chain management problem from a real case study is modeled and solved. A company in Pakistan wanted to outsource part of its warehousing activity to a third party logistics (3PL) provider. Consequently, the company had to decide on where to rent space in the 3PL warehouses. Knowing that such a strategic decision is affected by tactical and operational decisions, the problem is presented as a facility location problem integrating production, inventory, and distribution decisions. The problem is formulated as a mixed integer linear programming model which minimizes the total cost composed of location, distribution, production, and inventory costs. Several constraints specific to the situation and policy of the company were considered. A thorough analysis was done on the results obtained with respect to formulation efficiency, sensitivity analysis, and distribution of costs. In addition to the solution of the company problem, a set of 1215 problem instances was generated by varying five types of relevant costs in a full factorial manner. The solution of the generated problems always suggests to open in the same two locations and the integrality gaps averaged 0.062 % with a maximum of 0.102 %. On average, the major components of the total cost are production cost (96.6 %), transportation costs (2.7 %), and inventory holding costs (0.38 %). The total warehouse opening cost accounted for less than 0.05 % of the total costs. 相似文献
5.
Belkadi Ahlem Kenouche Samir Melkemi Nadjib Daoud Ismail Djebaili Rachida 《Structural chemistry》2022,33(3):833-858
Structural Chemistry - CHK1 is a promising molecular target that gained immense attention recently for the development of cancer therapeutics. In this study, a simulation-based investigation was... 相似文献
6.
Abderafik Benrabah Nadjib Boussetila Faouzia Rebbani 《Mathematical Methods in the Applied Sciences》2020,43(1):358-383
In this paper, we are interested in the inverse problem for the biharmonic equation posed on a rectangle, which is of great importance in many areas of industry and engineering. We show that the problem under consideration is ill-posed; therefore, to solve it, we opted for a regularization method via modified auxiliary boundary conditions. The numerical implementation is based on the application of the semidiscrete finite difference method for a sequence of well-posed direct problems depending on a small parameter of regularization. Numerical results are performed for a rectangle domain showing the effectiveness of the proposed method. 相似文献
7.
Lebouachera Seif El Islam Chemini Rachida Khodja Mohamed Grassl Bruno Tassalit Djilali Drouiche Nadjib 《Research on Chemical Intermediates》2018,44(12):7665-7690
Research on Chemical Intermediates - The adsorption of surfactant on reservoir rocks or sands is one of the main factors that can significantly reduce the effectiveness of surfactant flooding for... 相似文献
8.
Emad-Eldin A. A. Aly Nadjib Bouzar 《Annals of the Institute of Statistical Mathematics》2002,54(1):125-137
The multiplications of van Harn et al. (1982, Z. Wahrsch. Verw. Gebiete, 61, 97–118) are used to generalize the definition of -monotonicity of Olshen and Savage (1970, J. Appl. Probab., 7, 21–34) and Steutel (1988, Statist. Neerlandica, 42, 137–140) for distributions with support in Z
+ and R
+. Several characterizations are offered and a convolution property is established. Some relevant stability equations are solved and a relationship with the important concept of self-decomposability is noted. Poisson mixtures are used to deduce results for the R
+-case from those for the Z
+-case. 相似文献
9.
Shimizu S Miura A Khene S Nyokong T Kobayashi N 《Journal of the American Chemical Society》2011,133(43):17322-17328
Following the first suggestion of inherent molecular chirality in asymmetrically substituted subphthalocyanines by Torres and co-workers in 2000, elucidation of the relationship between structure and chirality has become an important issue. However, separation of the enantiomers has been prevented by the low solubility of the molecules synthesized to date, and it has not been possible to link the CD signs and intensities to their absolute structures. Recently, we observed that 1,2-subnaphthalocyanines possess two diastereomers with respect to the arrangement of the naphthalene moieties and that these novel chiral molecules exhibit moderate solubility in common organic solvents. This has enabled us to separate all of the diastereomers and enantiomers. The two diastereomers have been completely characterized by NMR spectroscopy and X-ray diffraction analysis. The absorption and magnetic circular dichroism spectra, together with theoretical calculation, reveal a small variation in the frontier molecular orbitals of the 1,2-subnaphthalocyanines compared with conventional subphthalocyanines, except for destabilization of the HOMO-3, which results in a characteristic absorption in the Soret band region. The chirality of 1,2-subnaphthalcyanines, including the CD signs and intensities, is discussed in detail for the first time with enantiomerically pure molecules whose absolute structures have been elucidated by single-crystal X-ray diffraction analysis. 相似文献
10.