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Bharathi Alagar Muthumani Narayanan Anbalagan Krishnamoorthy 《Transition Metal Chemistry》1997,22(6):586-588
The ground- and excited-state reactivities of the [Cr- (en)3]3+ (en=1,2-diaminoethane) and [Cr(NCS)6]3− ions in a polyacrylamide
(PAA) environment are reported. The aquation kinetics of these complexes has been studied to identify the effect of added
PAA with varying molecular weight. Aquation of the complexes in aqueous acid containing PAA yielded the respective substituted
products. The macromolecule in solution was found to decrease significantly the rate of ligand replacement. Similarly, photolysis
of the cationic and anionic complexes in water–PAA mixtures revealed a decrease in aquation quantum yield. Possible explanations
for the decrease in reaction rates and quantum yields are discussed.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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A simple and ecofriendly protocol has been developed for the expedient synthesis of novel dihydroindeno[1,2-b]pyrrol-4(3aH)-ones from the reaction of ninhydrin and (E)-N-methyl-1-(methylthio)-2-nitroethenamine or (E)-N-(1-(methylthio)-2-nitrovinyl)anilines. 相似文献
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R. Nageswara Rao Hassan Farah Prafulla Kumar Sahu Muthumani Janarthan Ch. Gangu Naidu 《Biomedical chromatography : BMC》2013,27(12):1733-1740
A stability‐indicating reverse‐phase high‐performance liquid chromatography–mass spectrometric method was developed and validated for the assay of metaxalone through forced degradation under acidic, alkaline, photo, oxidative and peroxide stress conditions. Separation of degradation products was accomplished on a reverse‐phase Phenomenex C18 (250 × 4.6 mm, 5 µm) column thermostated at 25°C using 10 mM aqueous ammonium acetate: methanol (35:65 v/v) as mobile phase in an isocratic mode of elution. The eluents were detected at 275 nm by photo diode array detector and mass detectors connected in series. Two unknown base hydrolysis products of metaxalone were identified and characterized as (a) methyl 3‐(3,5‐dimethylphenoxy)‐2‐hydroxypropylcarbamate and (b) 1‐(3,5‐dimethylphenoxy)‐3‐aminopropan‐2‐ol by MS, 1H NMR and FTIR spectroscopy. The method was validated as per International Conference on Harmonization guidelines and metaxalone was selectively determined in presence of its degradation impurities, demonstrating its stability‐indicating nature. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Jamal Moideen Muthu Mohamed Ali Alqahtani Thankakan Vimala Ajay Kumar Adel Al Fatease Taha Alqahtani Venkatesan Krishnaraju Fazil Ahmad Farid Menaa Ali Alamri Ranjini Muthumani Rajendran Vijaya 《Molecules (Basel, Switzerland)》2022,27(1)
Green synthesis of silver nanoparticles (AgNPs) was synthesized from fresh garlic extract coupled with isoniazid hydrazide (INH), a commonly used antibiotic to treat tuberculosis. A molecular docking study conducted with the selected compounds compared with anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis. The aqueous extract of garlic was prepared and mixed with silver nitrate (AgNO3) solution for the superfast synthesis of stable AgNPs. INH was then conjugated with AgNPs at different ratios (v/v) to obtain stable INH-AgNPs conjugates (AgNCs). The resulting AgNCs characterized by FTIR spectra revealed the ultrafast formation of AgNPs (<5 s) and perfectly conjugated with INH. The shifting of λmax to longer wavelength, as found from UV spectral analysis, confirmed the formation of AgNCs, among which ideal formulations (F7, F10, and F13) have been pre-selected. The zeta particle size (PS) and the zeta potential (ZP) of AgNPs were found to be 145.3 ± 2.1 nm and −33.1 mV, respectively. These data were significantly different compared to that of AgNCs (160 ± 2.7 nm and −14.4 mV for F7; 208.9 ± 2.9 nm and −19.8 mV for F10; and 281.3 ± 3.6 nm and −19.5 mV for F13), most probably due to INH conjugation. The results of XRD, SEM and EDX confirmed the formation of AgNCs. From UV spectral analysis, EE of INH as 51.6 ± 5.21, 53.6 ± 6.88, and 70.01 ± 7.11 %, for F7, F10, and F13, respectively. The stability of the three formulations was confirmed in various physiological conditions. Drug was released in a sustainable fashion. Besides, from the preferred 23 compounds, five compounds namely Sativoside R2, Degalactotigonin, Proto-desgalactotigonin, Eruboside B and Sativoside R1 showed a better docking score than trpD, and therefore may help in promoting anti-tubercular activity. 相似文献
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