K α L 1 satellite multiplet structure of photon-excited chlorine atoms

Summary An attempt is made to study theK _α L ¹ satellite multiplet structure of chlorine atoms in different compounds by photon excitation. A comparison of the averageK _α L ¹ group energy shift from the diagram line with those based on Dirac-Fock evaluations with different number ofM-shell electrons shows a reasonable agreement. The intensity ratios are found to be higher than those studied in Mg compounds in general.     

Errors in the determination of silica in lead-bearing samples caused by preliminary separation of lead sulphate

Some procedures for the gravimetric determination of silica in lead-bearing samples involve the extraction of lead sulphate with ammonium acetate. Results for silica are then low because some silica is dissolved in ammonium acetate solution. Correct results can be obtained only by avoiding fuming with sulphuric acid. If samples contain a large proportion of insoluble silica, preliminary fusion with sodium hydroxide is recommended.     

Use of isothermal microcalorimetry in pharmaceutical preformulation studies

Excipient compatibility of a new chemical entity was assessed using an isothermal microcalorimeter. Mixtures of an active pharmaceutical ingredient with a primary amine group and excipients were prepared in a 1:1 ratio and compatibility monitored by exposing to 50, 60 and 70°C in presence of 200 mL of water. The new chemical entity, a primary amine, reacted with reducing sugars such as lactose and resulted in a brown discoloration. This reaction is the Maillard type condensation reaction between amines and reducing sugars. The rate of reaction was dependent on the temperature with rapid degradation at higher temperatures. No other incompatibility was apparent between the primary amine and other excipients This revised version was published online in July 2006 with corrections to the Cover Date.     

Slope stability analysis using fracture mechanics approach

The analysis of slope failure is complicated due to its mechanism as well as the geological history of the slope. In classical slope stability analysis, the slope failure is assessed using the basic continuum mechanics or the limit equilibrium approach. This analysis, however, must be slightly modified when tension cracks exist at the upper edge of the slope. From post-mortem analyses of slope failures in the past, it was found that tension cracks had some considerable importance affecting the failure mechanism of the slope.Some attempts had also been directed in the past towards simple vertical cut slopes with tension cracks. Terzaghi [40]. Using an elasto-plastic model and a few analytical assumptions, Terzaghi [40] obtained an expression for a critical height of a vertical cut slope. However, since the stress distribution is changing during crack propagation, the failure mechanism cannot in principle conjecture from a static (undisturbed) stress field alone. In this report, a unified numerical approach combining Finite Element Method (FEM), fracture mechanics and remeshing technique is used to model the failure analysis of vertical cut slopes with tension cracks. Using this approach, the crack can be extended incrementally under a certain energy based failure criterion (Strain Energy Density criterion - SED) while taking into account the existing stress singularity field in the vicinity of the crack-tip.The use of fracture mechanics in soils, however, poses some difficulties in obtaining its relevant parameters due to the granular structure of soil. Because of its granular structure, the shear strength of soil depends on cohesion and the applied confining pressure making the determination of fracture parameters in soil difficult. These relevant parameters are not yet available in literature and hence, certain assumptions and interpolations had to be made in obtaining these parameters. Future research direction in this area is badly needed. Using a certain set of soil properties and crack geometry, a series of curves relating parameters S (Strain Energy Density Factor) and a non-dimensional variable N ( = H/C - slope height vs. crack distance from edge ratio) for vertical cut slopes can be constructed through numerous parametric studies. These curves can serve as a quick guide to obtain the critical height for a given vertical cut slope geometry with tension cracks.     

5∶6∶7∶8-hydroxyflavonols

Proceedings - Mathematical Sciences - A method of complete synthesis of 5∶6∶7∶8-hydroxy flavonols is described. It starts from...