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Glukhareva T. V. Morzherin Yu. Yu. Dyudya L. V. Malysheva K. V. Tkachev A. V. Padva A. Bakulev V. A. 《Russian Chemical Bulletin》2004,53(6):1311-1317
A method for the synthesis of previously inaccessible 5-dialkylamino-substituted 1,2,3-thiadiazole-4-carbaldehydes was developed. Ring transformation in these compounds induced by primary aliphatic and aromatic amines, hydroxylamines, and N-substituted hydrazines resulted in the synthesis of a broad range of 1,2,3-triazole-4-carbothioamide. 相似文献
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D"yachenko E. V. Glukhareva T. V. Nikolaenko E. F. Tkachev A. V. Morzherin Yu. Yu. 《Russian Chemical Bulletin》2004,53(6):1240-1247
A new method was developed for the one-step synthesis of spiro derivatives of fused quinolines by the reactions of ortho-amino derivatives of benzaldehyde with Meldrum"s acid, cyclohexane-1,3-dione, or N,N"-disubstituted barbituric acids. 相似文献
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Shou-Xin Wang Zhen Fang Zhi-Jin Fan Dun Wang Yue-Dong Li Xiao-Tian Ji Xue-Wen Hua Yun Huang Tatiana A. Kalinina Vasiliy A. Bakulev Yury Yu. Morzherin 《中国化学快报》2013,24(10):889-892
A series of novel tetrazole containing 1,2,3-thiadiazole derivatives were designed and synthesized via Ugi reaction. Their structures were confirmed by melting points, IR, 1H NMR, and HRMS (ESI). Preliminary bioassay indicated that most target compounds exhibited very good direct anti-TMV activity at 100 μg/mL, which was equal to or higher than that of ribavirin. Among them, compounds 4b, 4c and 4i also showed equivalent protection effect to ribavirin in vivo at 100 μg/mL. 相似文献
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Yu. Yu. Morzherin M. Yu. Kolobov V. S. Mokrushin M. Brauer E. Anders V. A. Bakulev 《Chemistry of Heterocyclic Compounds》2000,36(1):22-36
A series of N-alkyl- and N-aryl-2-cyano-2-diazoacetamides was synthesized by the reaction of 2-amino-2-cyanoacetamides with sodium nitrite in hydrochloric acid. The mechanism of their heteroclectrocyclization to 5-hydroxy-1,2,3-triazoles was investigated kinetically and theoretically by the B3LYP/6-31+G* method. The conclusion was made on the basis of the determined activation energy of the cyclization process. reaction parameters , and kinetic isotope effects, that there is a difference between the mechanisms of cyclization of the N-alkyl and N-aryl derivatives of 2-cyano-2-diazoacetamide; cyclization of the N-alkyl derivatives takes place by a monorotatory mechanism, while cyclization of the N-aryl derivatives takes place by a mechanism where one of the stages is heteroelectrocyclization of 2-diazoacetimidates.For Communication 5, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 26–41, January, 2000. 相似文献
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