Tabu search applied to the general fixed charge problem

Recent successes in applying tabu search to a wide variety of classical optimization problems have motivated the investigation of applying tabu search to the well-known general fixed charge problem (GFCP). In this paper, an adaptation of tabu search to GFCP is described and computational results are given. In addition, the computational results are compared with those obtained from SWIFT-2, the most well-known and frequently used heuristic method for GFCP. As will be shown, the results are very encouraging.     

Recent advances in analytical construct resins

The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring and analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this 'analytical bottleneck' Geysen, in 1996 elaborated Merrifield's initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.     

Metastable Ionic Diodes Derived from an Amine‐Based Polymer of Intrinsic Microporosity

A highly rigid amine‐based polymer of intrinsic microporosity (PIM), prepared by a polymerization reaction involving the formation of Tröger’s base, is demonstrated to act as an ionic diode with electrolyte‐dependent bistable switchable states.