Flow-injection determination of nitrite and nitrate with biamperometric detection at two platinum wire electrodes

The flow-injection determination of nitrite is based on oxidation of iodide by nitrite. The triiodide formed is detected amperometrically in a flow-through cell with two teflonized graphite or platinum wire electrodes polarized with a voltage of 100 mV. More sensitive and faster response was observed with the platinum wire electrodes. The same detector is used for determination of nitrate after reduction to nitrite in a reductor column containing copperized cadmium. Detection limits under optimized conditions are 6 μg l^?1 for both nitrite- and nitrate-nitrogen. Effects of oxygen and interfering metal ions are discussed.     

Fluorogenic reaction between adenine derivatives and chloroacetaldehyde and its application to the determination of 9-(2-chloro-6-fluorobenzyl)adenine in human plasma

A sensitive (1 ng ml^?1) liquid chromatographic method with fluorescence detection is described for the determination of arprinocid and analogous compounds in human plasma. The method is based on chemical derivatization with chloroacetaldehyde to form highly fluorescent derivatives. Extraction of the drug from plasma and separation of the derivative from the reaction mixture are accomplished by solid-phase extraction with two silica cartridges. The effects of pH, solvent, and concentration of the reagents on the efficiency of derivatization were studied. The assay in plasma was validated in the 1–50 ng ml^?1 range. The fluorescent derivatives were synthesized and fully characterized. The derivatives were also found to be efficient as energy acceptors in the oxalate ester/hydrogen peroxide chemiluminescent system.     

Flow-injection single-point titration of acids with biamperometric detection at polarized platinum electrodes

Flow-injection single-point titration of acids is based on biamperometric measurement of iodine formed quantitatively in the reaction of iodide with iodate. Results are presented for determination of sulphuric, hydrofluoric, monochloroacetic, formic and acetic acids. The slopes of the calibration plots, which are linear for about 1–10 rum acid, depend on the strength of the acid, decreasing from sulphuric acid to acetic acid. With microcomputer on-line data processing, relative standard deviations were about 0.2%.     

A potassium-selective electrode with solid internal contact

The performance characteristics of potassium-selective electrodes made with valinomycin membranes plasticized with dioctyl adipate or sebacate, and with a solid silver contact or an internal solution, have been critically examined. The choice of electrode depends on a number of factors, including the interfering ion(s) present. The electrodes can be used for determination of potassium in natural waters.     

Modification of nonionic adsorbent with eriochrome blue-black R for selective nickel(II) preconcentration in conventional and flow-injection atomic-absorption spectrometry

Chemical modification of nonionic sorbent Amberlite XAD-2 or anion exchanger Amberlyst A-26 with Eriochrome Blue-Black R (EBBR) produces a chelating resin of satisfactory chemical stability and resistance towards mineral acids. Retention of 10 metal ions has been examined for both resins. EBBR loaded XAD-2 was utilized for nickel(II) preconcentration in atomic-absorption spectrometry. In optimal conditions at a preconcentration time not exceeding 1 hr, nickel(II) can be determined at the 0.1 mug/l. level in flow measurements. Retention of metal ions on chelating resin is a convenient method of preconcentration and elimination of matrix interferences.     

Fully three dimensional breather solitons can be created using feshbach resonances

We investigate the stability properties of breather solitons in a three-dimensional Bose-Einstein condensate with Feshbach resonance management of the scattering length and confined only by a one-dimensional optical lattice. We compare regions of stability in parameter space obtained from a fully 3D analysis with those from a quasi-two-dimensional treatment. For moderate confinement we discover a new island of stability in the 3D case, not present in the quasi-2D treatment. Stable solutions from this region have non-trivial dynamics in the lattice direction; hence, they describe fully 3D breather solitons. We demonstrate these solutions in direct numerical simulations and outline a possible way of creating robust 3D solitons in experiments in a Bose-Einstein condensate in a one-dimensional lattice. We point out other possible applications.     

Exciton supersolidity in hybrid Bose-Fermi systems

We investigate the ground states of a Bose-Einstein condensate of indirect excitons coupled to an electron gas. We show that in a properly designed system the crossing of a roton minimum into the negative energy domain can result in the appearance of the supersolid phase, characterized by periodicity in both real and reciprocal space. Accounting for the spin-dependent exchange interaction of excitons we obtain ferromagnetic supersolid domains. The Fourier spectra of excitations of weakly perturbed supersolids show pronounced diffraction maxima which may be detected experimentally.     

Computerized flow injection potentiometric stripping analysis with large-volume wall-jet cell

Summary A microcomputer system for flow injection potentiometric stripping analysis is presented permitting fast digital recording of potential time-curves. A large-volume wall-jet cell simple in design has been used as detector cell. Investigations about the influence of electrode pretreatment and solution delivery mode (i.e. gravity flow, pumping) reveal the strong influence of these parameters on the magnitude and precision of stripping times. The optimized system was applied to the simultaneous determination of cadmium and lead in geological samples.

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Computerisierte Potentiometrische Stripping Analyse in einem Fließinjektionssystem mit großvolumiger Wall-jet Zelle

     

Improved determination of the bisphosphonate alendronate in human plasma and urine by automated precolumn derivatization and high-performance liquid chromatography with fluorescence and electrochemical detection.

An improved method for the determination of 4-amino-1-hydroxybutane-1,1-bisphosphonic acid (alendronate) in human urine and an assay in human plasma are described. The methods are based on co-precipitation of the bisphosphonate with calcium phosphates, automated pre-column derivatization of the primary amino group of the bisphosphonic acid with 2,3-naphthalene dicarboxyaldehyde (NDA)-N-acetyl-D-penicillamine (NAP) or cyanide (CN-) reagents, and high-performance liquid chromatography (HPLC) with electrochemical (ED) or fluorescence detection (FD). The feasibility of ED of the NDA-CN- derivative of aldendronate has been demonstrated, and a HPLC-ED assay in human urine has been validated in the concentration range 2.5-50.0 ng/ml. In order to eliminate the cyanide ion from the assay procedure, several other nucleophiles in the NDA derivatization reaction were evaluated. An NDA-NAP reagent was found to produce highly fluorescent derivatives of alendronate. The assay in urine based on NDA-NAP derivatization and HPLC-FD has been developed and fully validated in the concentration range 1-25 ng/ml. Based on the same NDA-NAP derivatization, an assay in human plasma with a limit of quantification of 5 ng/ml has also been developed. Both HPLC-FD assays were utilized to support various human pharmacokinetic studies with alendronate.