Peptoids as source of compounds eliciting antibacterial activity

N-Alkylglycine oligomers (peptoids) constitute a family of non-natural peptidomimetics attractive for the early drug discovery process because of their physicochemical features, easy of adaptation to combinatorial chemistry approaches and their proteolytic stability. Consequently, peptoid libraries have found application for discovering hits against a wide diversity of pharmaceutical targets, among which different examples of antibacterials are found. In the present work, research efforts addressed towards the identification of peptoids as antibacterial agents are discussed.     

Quasi-degenerate neutrinos and lepton flavor violationin supersymmetric models

In supersymmetric models the misalignment between fermion and sfermion families introduces unsuppressed flavor-changing processes. Even if the mass parameters are chosen to give no flavor violation, family dependent radiative corrections make this adjustment not stable. We analyze the rate of in SUSY-GUT models with three quasi-degenerate neutrinos and universal scalar masses at the Planck scale. We pay special attention to a recently proposed scenario where the low-energy neutrino mixings are generated from identical quark and lepton mixings at large scales. We show the following. (i) To take universal slepton masses at the GUT scale is a very poor approximation, even in no-scale models. (ii) For large neutrino Yukawa couplings the decay would be observed in the planned experiment at PSI. (iii) For large values of the tau coupling gives important corrections, pushing and to accessible rates. In particular, the non-observation of these processes in the near future would exclude the scenario with unification of quark and lepton mixing angles. (iv) The absence of lepton flavor violating decays in upcoming experiments would imply a low value of , small neutrino couplings, and large ( GeV) SUSY-breaking masses.     

On the use of Monte Carlo simulation,cache and splitting techniques to improve the Clarke and Wright savings heuristics

This paper presents the SR-GCWS-CS probabilistic algorithm that combines Monte Carlo simulation with splitting techniques and the Clarke and Wright savings heuristic to find competitive quasi-optimal solutions to the Capacitated Vehicle Routing Problem (CVRP) in reasonable response times. The algorithm, which does not require complex fine-tuning processes, can be used as an alternative to other metaheuristics—such as Simulated Annealing, Tabu Search, Genetic Algorithms, Ant Colony Optimization or GRASP, which might be more difficult to implement and which might require non-trivial fine-tuning processes—when solving CVRP instances. As discussed in the paper, the probabilistic approach presented here aims to provide a relatively simple and yet flexible algorithm which benefits from: (a) the use of the geometric distribution to guide the random search process, and (b) efficient cache and splitting techniques that contribute to significantly reduce computational times. The algorithm is validated through a set of CVRP standard benchmarks and competitive results are obtained in all tested cases. Future work regarding the use of parallel programming to efficiently solve large-scale CVRP instances is discussed. Finally, it is important to notice that some of the principles of the approach presented here might serve as a base to develop similar algorithms for other routing and scheduling combinatorial problems.     

Synthesis of a library of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives and identification of bioactive compounds

The design and synthesis of a library of novel families of 3-oxopiperazinium and perhydro-3-oxo-1,4-diazepinium derivatives is reported. The library was composed of 44 3-oxopiperazinium derivatives (11 of these compounds had a spiranic skeleton) and 22 perhydro-3-oxo-1,4-diazepinium compounds. The synthetic procedure involved a 6-step sequence carried out in solution, along with the use of solid-phase linked scavengers and microwave activation for the rapid removal of the excess of amine reagents. A final cyclization step performed under mild conditions led to the charged heterocyclic moiety. Screening of this library in two biological assays identified active compounds that inhibit the activity of the vanilloid receptor TRPV1 and modulators of the multidrug resistance phenomenon. Thus, this synthetic sequence represents a facile and convenient entry to unprecedented libraries of this sort of tetraalkylammonium derivatives that may be of use for identification of novel scaffolds of diverse biological activity.     

Reaktivität der Pyrrolpigmente, 2. Mitt.: Deprotonierung von 3-Pyrrolin-2-onen

Deprotonation of 3,4-dimethyl-3-pyrrolin-2-on (1) int-butyl alcohol/potassiumt-butoxide solutions takes place on the N atom, as shown by¹H/²H exchange andpK _a determinations of1 (pK=17.1), 1,3,4-trimethyl-3-pyrrolin-2-one (pK _a =17.6), and 3,4-dimethyl-5-methoxy-2_H-pyrrole (pK _a =16.7). The SCF-MO approximation MINDO/3 indicates, however, that in the gas phase deprotonation of1 should occur at the C atom.

1.Mitt.:Ribó, J. M., Trull, F., Mh. Chem.110, 201 (1979).     

TeV strings and the neutrino-nucleon cross section at ultrahigh energies

In scenarios with the fundamental unification scale at the TeV one expects string excitations of the standard model fields at accessible energies. We study the neutrino-nucleon cross section in these models. We show that duality of the scattering amplitude forces the existence of a tower of massive leptoquarks that mediate the process in the s channel. Using the narrow-width approximation we find a sum rule for the production rate of resonances with different spin at each mass level. We show that these contributions can increase substantially the standard model neutrino-nucleon cross section, although they seem insufficient to explain the cosmic ray events above the Greisen-Zatsepin-Kuz'min cutoff energy.     

A positional scanning combinatorial library of peptoids as a source of biological active molecules: identification of antimicrobials

A positional scanning library of N-alkylglycine trimers (peptoids) containing over 10 000 compounds has been synthesized on solid phase. The synthetic pathway involved the use of the submonomer strategy and a set of 22 commercially available primary amines as a chemical diversity source. The unbiased nature of the library allowed its screening against a variety of biological targets, leading to the identification of individual peptoids exhibiting remarkable biological activities (García-Martínez, C. et al. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 2374. Montoliu, et al. J. Pharm. Exp. Therap. 2002, 302, 29. Planells-Cases, R., et al. J. Pharm. Exp. Therap. 2002, 302, 163). In the present work, the screening of this library against a panel of Gram-positive and Gram-negative bacteria led to the identification of different compounds exhibiting antimicrobial activity.