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1.
We will discuss the Gorenstein property of the singularity which is blown down from the minimal section of a ruled surface in terms of the extension class. In the case that the base field has positive characteristic, we find a new example (3.4) of Gorenstein singularity in connection with Theorem B. 相似文献
2.
Kiyoshi Mochizuki 《Journal of Mathematical Analysis and Applications》2007,326(1):582-588
We show that the energy of solutions to the initial boundary value problem for the wave equation in exterior domains with a dissipation which is localized only near infinity tends to zero as the time goes to infinity. We do not make any geometrical condition like star-shapedness on the boundary. 相似文献
3.
Kazuhiro Kurata Masataka Shibata Shigeru Sakamoto 《Applied Mathematics and Optimization》2004,50(3):259-278
Let $\Omega$ be a bounded domain in ${\bf R^n}$ with Lipschitz
boundary,
$\lambda >0,$ and $1\le p \le (n+2)/(n-2)$ if $n\ge 3$ and $1\le p< +\infty$
if $n=1,2$. Let $D$ be a measurable subset of $\Omega$ which belongs
to the class
$
{\cal C}_{\beta}=\{D\subset \Omega \quad | \quad |D|=\beta\}
$
for the prescribed $\beta\in (0, |\Omega|).$
For any $D\in{\cal C}_{\beta}$, it is well known that
there exists a unique
global minimizer $u\in H^1_0(\Omega)$, which we denote by
$u_D$, of the functional
\[\quad
J_{\Omega,D}(v)=\frac12\int_{\Omega}|\nabla v|^2\,
dx+\frac{\lambda}{p+1}\int_{\Omega}|v|^{p+1}\, dx
-\int_{\Omega}\chi_Dv\,dx
\]
on $H^1_0(\Omega)$.
We consider the optimization problem
$
E_{\beta,\Omega}=\inf_{D\in {\cal C}_{\beta}} J_D(u_D)
$
and say that
a subset $D^*\in {\cal C}_{\beta}$ which attains
$E_{\beta,\Omega}$
is an optimal configuration to this problem.
In this paper we show the existence, uniqueness
and non-uniqueness, and
symmetry-preserving and symmetry-breaking phenomena of the
optimal configuration $D^*$ to this
optimization problem in various settings. 相似文献
4.
Nishida H Miyazaki Y Kitamura Y Ohashi M Matsusue T Okamoto A Hosaka Y Ohnishi S Mochizuki H 《Chemical & pharmaceutical bulletin》2001,49(10):1237-1244
Intravascular clot formation is an important factor in a number of cardiovascular diseases. Therefore, the prevention of blood coagulation has become a major target for new therapeutic agents. One attractive approach is the inhibition of factor Xa (FXa), which is a key enzyme in coagulation cascade responsible for the generation of thrombin by limited proteolysis of its zymogen, prothrombin. We have investigated 1-arylsulfonyl-3-piperazinone derivatives, containing a 4-(piperidino)pyridine group in place of guanidino and/or amidino groups, and discovered compound M55113 (30a: 4-[(6-Chloro-2-naphthalenyl)sulfonyl]-1-[[1-(4-pyridinyl)-4-piperidinyl]methyl]piperazinone), as a potent inhibitor of FXa (IC50=0.06 microM) with high selectivity for FXa over trypsin and thrombin. 相似文献
5.
Fumoto M Hinou H Ohta T Ito T Yamada K Takimoto A Kondo H Shimizu H Inazu T Nakahara Y Nishimura S 《Journal of the American Chemical Society》2005,127(33):11804-11818
The chemoselective polymer blotting method allows for rapid and efficient synthesis of glycopeptides based on a "catch and release" strategy between solid-phase and water-soluble polymer supports. We have developed a heterobifunctional linker sensitive to glutamic acid specific protease (BLase). The general procedure consists of five steps, namely (i) the solid-phase synthesis of glycopeptide containing BLase sensitive linker, (ii) subsequent deprotections and the release of the glycopeptide from the resin, (iii) chemoselective blotting of the glycopeptide intermediates in the presence of water-soluble polymers with oxylamino functional groups, (iv) sugar elongations using glycosyltransferases, and (v) the release of target glycopeptides from the polymer platform by selective BLase promoted hydrolysis. The combined use of the solid-phase chemical syntheses of peptides and the enzymatic syntheses of carbohydrates on water-soluble polymers would greatly contribute to the production of complicated glycopeptide libraries, thereby enhancing applicative research. We report here a high-throughput synthetic system for the various types of MUC1 glycopeptides exhibiting a variety of sugar moieties. It is our belief that this concept will become part of the entrenched repertoire for the synthesis of biologically important glycopeptides on the basis of glycosyltransferase reactions in automated and combinatorial syntheses. 相似文献
6.
Konda-Yamada Y Asano K Satou T Monma S Sakayanagi M Satou N Takeda K Harigaya Y 《Chemical & pharmaceutical bulletin》2005,53(5):529-536
Oxopropyl E-(pyrrolidine-2-ylidene)glycinamide (5c) and allyl E-(pyrrolidine-2-ylidene)glycinate (5d) were effectively synthesized from 2,3,5-tri-O-benzyl-4-O-tert-butyldimethylsilyl(TBDMS)-D-arabinal (7) using intramolecular 1,3-dipolar cyclic reaction of azide and olefin as a key reaction. These results proved this cyclic reaction should be applicable for the synthesis of various (pyrrolidine-2-ylidene)glycinate and glycinamide. In addition, the development of a synthetic route for the precursor of an unsaturated cyclic dehydro amino acid involved in azinomycins (carzinophilin) using relating glycinate, methyl E-(pyrrolidine-2-ylidene)glycinate (5a) was described. 相似文献
7.
Keiichiro Fukumoto Masatoshi Chihiro Yuichi Shiratori Masataka Ihara Tetsuji Kametani Toshio Honda 《Tetrahedron letters》1982,23(29):2973-2976
Thermolysis of a benzocyclobutene derivative () prepared from norcamphor produced stereoselectively a tetracyclic compound (), which was converted to a lactone () having correct stereochemistry at C7, C8, C9, C11, C13, and C14 positions of (±)-klaineanone. 相似文献
8.
Yohei Hashimoto Masataka Moriyasu Eiko Kato Masaru Endo Naohiko Miyamoto Hiroshi Uchida 《Mikrochimica acta》1978,70(1-2):159-167
Summary A new type of detector for high-pressure liquid chromatography has been designed. This detector is equipped with a RC resonance circuit, and is similar to the capacitance detector previously reported. It is operated as a capacitance detector with nonpolar eluents; while with polar solvents, it behaves as a conductance detector. Electrolytes such as salts, acids and bases are sensitively detected. The detector was successfully used for the detection of fatty acids and alkaloids.
Zusammenfassung Ein neuartiger Detektor für die Hochdruck-Flüssigchromatographie wurde entwickelt. Dieser ist mit einem Resonanzstromkreis ausgestattet und ähnelt dem kürzlich beschriebenen Kapazitanz-Detektor. Als solcher funktioniert er mit nichtpolaren Eluenten, während er sich mit polaren Lösungsmitteln wie ein Leitfähigkeitsdetektor verhält. Salze, Säuren und Basen werden empfindlich nachgewiesen. Das Gerät wurde zum Nachweis von Fettsäuren und Alkaloiden verwendet.相似文献
9.
Several 2,4-diaminothiazoles and 2,4-diaminothiophenes could be easily obtained by metallation using LDA from aminomethylthiomethylenecyanamides and aminomethylthiomethylenemalononitrile, respectively. 相似文献
10.
(±)-1-Benzyl-3α-hydroxy-4β-methylamino-2-oxopyrrolidine (15) and its cis-isomer (16) were synthesised from 1-benzyl-4-ethoxycarbonyl-2,3-dioxopyrrolidine (2) in several steps. The former (15) was converted to 3-benzyl-6-methyl-2-oxo-3,6-diazabicyclo[3.1.0]hexane (17) with a mixture of triphenylphosphine, carbon tetrachloride and triethylamine. 相似文献