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1.
Klai Nadia Berredjem Malika Khettache Nawel Belghit Med Yazid Rgaïnia Zine Nour‐Eddine Aouf 《Journal of heterocyclic chemistry》2004,41(1):57-60
Dedicated to the memory of Pr. Ladjama Daif A series of chiral cyclosulfamides have been synthesized by alkaline cyclisation starting from N‐benzoylamino acids (Ala, Val, Leu, Phe) derivatives and chlorosulfonyl isocyanate. A simplified and regioselective deprotection of the cyclic compounds (cyclosulfamides) containing the tert‐butyloxycarbonyl group (Boc) has been achieved in good yield by fusion under reduced pressure. 相似文献
2.
This paper proposes a fully three‐dimensional non‐linear Euler methodology for solving aerodynamic and acoustic problems in the presence of strong shocks and rarefactions. It uses a discontinuous Galerkin method (DGM) within the element, and a Riemann solver (HLLC) at the boundaries to propagate rarefactions while preserving the entropy condition and capturing shocks with no spurious oscillations. This approach is thought to marry the best aspects of finite element and finite volume methods, achieving conservation while not requiring the solution of a large matrix. Examples in which shock and rarefaction waves are well captured are presented and the propagation of acoustic pulses is well demonstrated. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
3.
Ashok Zakkula Sreekanth Dittakavi Malika Muskan Maniyar Naveem Syed Suresh P. Sulochana Mohd Zainuddin Ramesh Mullangi 《Biomedical chromatography : BMC》2019,33(11)
Isocitrate dehydrogenase (IDH) inhibitors comprise a novel class of anticancer drugs, which are approved to treat acute myeloid leukemia patients having mutations on IDH1/2. We report the development and validation of a high‐performance liquid chromatography (HPLC) method for the simultaneous quantitation of IDH inhibitors, namely enasidenib (EDB), ivosidenib (IDB) and vorasidenib (VDB), in mouse plasma as per the US Food and Drug Administration regulatory guidelines. The method involves extraction of EDB, IDB and VDB along with internal standard (IS; phenacetin) from mouse plasma (100 μl) using a simple protein precipitation process. The chromatographic analysis was performed on an HPLC system using a gradient mobile phase (comprising 10 mm ammonium acetate and acetonitrile in a flow‐gradient) and an X‐Terra Phenyl column. The UV detection wave length was set at λmax 265 nm. EDB, IDB, VDB and the IS eluted at 7.36, 8.60, 9.50 and 5.12 min, respectively, with a total run time of 10 min. The calibration curve was linear over a concentration range of 0.20–12.5 μg/ml for EDB and 0.50–12.5 μg/ml for IDB and VDB (r2 = ≥0.998 for all of the analytes). Validation results met the acceptance criteria. The validated HPLC method was successfully applied to a pharmacokinetic study in mice. 相似文献
4.
Samia Guezane Lakoud Malika Berredjem Nour-Eddine Aouf 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):762-768
Abstract A new series of modified α-amidophosphonates (or β-ketophosphonate) was synthesized by an efficient method, starting from aminoesters and chloroacetyl chloride. We have established that chloroacetyl chloride is a suitable reagent allowing the introduction a halogen moiety for the Arbuzov reaction. The α-amidophosphonates were prepared in two steps (acetylation, phosphorylation). Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. 相似文献
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Radia Bouasla Hadjira Berredjem Malika Berredjem Malika Ibrahim‐Oualid Assia Allaoui Marc Lecouvey Nour‐Eddine Aouf 《Journal of heterocyclic chemistry》2013,50(6):1328-1332
A new series of chiral 5‐substituted bis‐oxazolidinones containing an acylsulfonamide moiety has been synthesized starting from chlorosulfonyl isocyanate, (l )‐ethyl lactate, and oxazolidin‐2‐ones. All the reactions were conducted at ambient temperature, and the N‐acylsulfonamide bis‐oxazolidin‐2‐ones were obtained with high yields within 2 h. Some of the newly synthesized compounds were evaluated in vitro against the virulent strain RH of Toxoplasma gondii and the human lymphocytes, and showed promising results. 相似文献
7.
A new total synthesis of Otanthus Maritima amide 1 was achieved from 6-trimetylsily N-tert-butyl sorbaldimine 6 in 76% global yield. The natural product 1 was obtained in three steps by condensation of 6 on thiophenal in the presence of catalytic amount of CsF (10%) in DMSO followed by oxidation and amidification of the corresponding intermediate. 相似文献
8.
Israël-Martyr Mbomekallé Bassem S. Bassil Andreas Suchopar Bineta Keita Louis Nadjo Malika Ammam Mohamed Haouas Francis Taulelle Ulrich Kortz 《Journal of Cluster Science》2014,25(1):277-285
We report on an improved synthesis and structural characterization of the cyclic 48-tungsto–8-arsenate(V) [H4As8W48O184]36? (1). The mixed lithium–potassium salt of this polyanion, K26.5Li9.5[H4As8W48O184]·90H2O (KLi-1), has been studied in the solid state by IR, single-crystal X-ray diffraction, and elemental analysis, and in solution by 183W NMR spectroscopy. 相似文献
9.
In the framework of systematic investigations in the properties of rare-earth cyclotriphosphates, polycristalline samples of La1−xNdxP3O9·3H2O have been synthesized with x=5×10−3, 10−2, 5×10−2, 10−1 and 1. Absorbance spectra were measured at 300 K in the 300-1000 nm region. Fluorescent emissions from the 4F3/2 multiplet were observed at 300 and 6 K under pulsed laser excitations in either the 4F7/2 or 4F3/2 multiplet and the decays of these emissions were measured. These decays are exponential with decay-times on the order of 100 ns for all values of x. No important lengthening is observed as either the Nd concentration is decreased from 100 to 0.5 at% or the temperature is lowered from 300 to 6 K. These results are in contradiction with those obtained for the anhydrous La1−xNdx(PO3)3 compounds prepared by progressively heating the corresponding La1−xNdxP3O9·3H2O powder materials, a fact which shows the predominant role played by the water molecules in the Nd3+ luminescence in the considered hydrated compounds. 相似文献
10.
Stability analysis of jointed rock slope 总被引:2,自引:0,他引:2
The stability analysis of a jointed rock slope with two sets of unfilled joints, under its own weight, is carried out directly by considering failure surfaces along some particular joints and also going through the intact rock. Simple failure mechanisms using uniform rigid rock-block motions are incorporated in the yield design kinematic approach. They yield an improvement of known results as long as the characteristics strength of the joints are weak enough. 相似文献