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Heidie L. Frisco‐Cabanos Naohiro Takemoto Junichiro Takaya Dr. Shin‐ichi Sato Dr. Sayumi Yamazoe Prof. Yoshinobu Takakura Prof. Shigeru Kinoshita Dr. Makiya Nishikawa Prof. Noriko Koizumi Prof. Motonari Uesugi 《Angewandte Chemie (International ed. in English)》2014,53(42):11208-11213
One of the major problems encountered in cell transplantation is the low level of survival of transplanted cells due to detachment‐induced apoptosis, called anoikis. The present study reports on the chemical synthesis and biological evaluation of water‐soluble molecules that protect suspended cells from anoikis. The synthetic molecules bind to and induce clusters of integrins and heparan‐sulfate‐bound syndecans, two classes of receptors that are important for extracellular matrix‐mediated cell survival. Molecular biological analysis indicates that such molecules prolong the survival of suspended NIH3T3 cells, at least in part, by promoting clustering of syndecan‐4 and integrin β1 on the cell surface, leading to the activation of small GTPase Rac‐1 and Akt. In vivo experiments using animal disease models demonstrated the ability of the molecules to improve cell engraftment. The cluster‐inducing molecules may provide a starting point for the design of new synthetic tools for cell‐based therapy. 相似文献
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Katsuya Maeyama Yasushi Fujiwara Makiya Nishimuro Yasuhiko Yoshida Noriyuki Yonezawa 《合成通讯》2013,43(5):603-609
2,2′‐Alkyl‐disubstituted 4,4′‐oxybiphenols (4) were prepared in good yields through esterification of 4,4′‐oxybiphenol (1), AlCl3‐promoted Fries rearrangement, and AlCl3/NaBH4‐promoted reduction reaction. 相似文献
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