A simple and cost-effective synthesis of sulfated β-cyclodextrin and its application as chiral mobile phase additive in the separation of cloperastine enantiomers

Journal of Inclusion Phenomena and Macrocyclic Chemistry - A simple and cost-effective method for the synthesis of sulfated β-cyclodextrin, one of the most widely used chiral mobile phase...     

Synthesis of new oxamide-based ligand and its coordination behavior towards copper(II) ion: spectral and electrochemical studies

A new ligand N,N'-bis{3-(2-formyl-4-methyl-phenol)-6-iminopropyl}oxamide (L) and its mono- and binuclear copper(II) complexes have been synthesized and characterized. The ligand shows absorption maxima at 249 and 360 with a weak transition at 455 nm. The ligand was found to be fluorescent and shows an emission maximum at 516 nm on excitation at 360 nm. The electronic spectra of the mono- and binuclear Cu(II) complexes exhibited a d-d transition in the region 520-560 nm characteristic of square planar geometry around Cu(II) ion. The ESR spectrum of the mononuclear complex showed four lines with nuclear hyperfine splitting. The binuclear complex showed a broad ESR spectrum with g=2.10 due to antiferromagnetic interaction between the two Cu(II) ions. The room-temperature magnetic moment values (micro(eff)) for the mono- and binuclear Cu(II) complexes are found to be 1.70 micro(B) and 1.45 micro(B), respectively. The electrochemical studies of the mononuclear Cu(II) complex showed a single irreversible one-electron wave at -0.70 V (E(pc)) and the binuclear Cu(II) complex showed two irreversible one-electron reduction waves at -0.75 V (E(pc)(1)) and -1.27 V (E(pc)(2)) in the cathodic region.     

Eggshell Derived Europium Doped Hydroxyapatite Nanoparticles for Cell Imaging Application

Journal of Fluorescence - Hen’s eggshell, a biological waste product, was turned into a cell imaging probe: europium doped hydroxyapatite (HAp: Eu) nanoparticle using hydrothermal method....     

Synthesis and Characterization of a Chitosan-bearing Binucleating Ligand and Its pH Dependency on Copper(II) Adsorption

A novel chitosan derivative has been synthesized by the condensation of a binucleating ligand, 2,6-bis[(N-methylpiperazine-1-yl)methyl]-4-formylphenol (BNL), with chitosan (CTS). The resulting material (CTS-BNL) was characterized and its adsorption properties towards copper(II) ions in aqueous solutions of various pH have been studied, the adsorption capacity (Q(e)) is about 0.94 mmol g(-1) at pH 6 and 1.45 mmol g(-1) at pH 8.5. This higher adsorption capacity may be due to the binucleating ligand anchored to chitosan.     

Synthesis and electrochemical sensing behaviour of a new ferrocene functionalized tet ‘a’ macrocyclic receptor towards transition metal ions

A new ferrocene functionalized macrocyclic receptor 1,8‐bis(ferrocenylmethyl)‐5,5,7,12,12,14‐hexamethyl‐1,4,8,11‐tetraazacyclotetradecane (R) has been designed and synthesized to study its potential application as chemosensor. The receptor has been characterized by spectral techniques and X‐ray diffraction. The compound crystallizes in the orthorhombic space group Pcab with four molecules in a unit cell (half‐a‐molecule in the asymmetric unit). The electrochemical studies of the receptor in dioxane–water (7:3 v/v, 25 °C) indicate that the receptor is pH‐dependent with a displacement of E_1/2 to more anodic potentials with a decrease in the pH from 12 to 5. The electrochemical behaviour of R was also studied in the presence of Mn²⁺, Co²⁺, Ni²⁺, Cu²⁺ and Zn²⁺ in dioxane–water (7:3 v/v, 25 °C, [Buⁿ₄N][ClO₄]), showing that upon complexation the ferrocene–ferrocenium half‐wave potential shifts anodically in relation to that of the free receptor. The maximum electrochemical shift (ΔE_1/2) of 46 mV was found in the presence of Cu²⁺, followed by Co²⁺ (20 mV), Mn²⁺ (15 mV), Ni²⁺ (13 mV) and Zn²⁺ (9 mV). Moreover, the receptor R is able to electrochemically and selectively sense Cu²⁺ in the presence of the other transition metal cations studied. Copyright © 2007 John Wiley & Sons, Ltd.     

Design of the First‐in‐Class,Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction

The structure‐based design of M‐525 as the first‐in‐class, highly potent, irreversible small‐molecule inhibitor of the menin‐MLL interaction is presented. M‐525 targets cellular menin protein at sub‐nanomolar concentrations and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL‐regulated gene expression in MLL leukemia cells. M‐525 demonstrates high cellular specificity over non‐MLL leukemia cells and is more than 30 times more potent than its corresponding reversible inhibitors. Mass spectrometric analysis and co‐crystal structure of M‐525 in complex with menin firmly establish its mode of action. A single administration of M‐525 effectively suppresses MLL‐regulated gene expression in tumor tissue. An efficient procedure was developed to synthesize M‐525. This study demonstrates that irreversible inhibition of menin may be a promising therapeutic strategy for MLL leukemia.