TLC Based Method for Standardization of Pongamia pinnata (Karanj) Using Karanjin as Marker

Pongamia pinnata Linn. (Papilionaceae) seeds have gained great commercial and industrial importance owing to their high oil content. Presently, there is no appropriate TLC based method available for standardization of P. pinnata. A simple, robust and reproducible TLC method for the determination of Karanjin is reported in the seeds of P. pinnata. The method involves separation of components by TLC on pre-coated silica gel G 60 F₂₅₄ plates developed on toluene: ethyl acetate (7:3 v/v) and detection at 260 nm in absorbance mode. The sensitivity of the method was found to be 100 ng. The linearity range was 50–300 ng. Four samples of P. pinnata from different geographical locations were tested for their karanjin content using the developed method. The proposed method was found to be robust, precise, and accurate, it therefore holds potential for detection, monitoring and quantification of karanjin in Pongamia pinnata.

     

Synthesis of rimonabant regioisomer

A novel synthesis route for a rimonabant regioisomer was developed. Correspondence: Rakeshwar Bandichhor, Innovation Plaza, IPD, R&D, Dr. Reddy’s Laboratories Ltd., Survey Nos. 42, 45, 46 & 54, Bachupally, Qutubullapur, R. R. Dist. 500073, A.P., India; Chitneni Prasad Rao, Department of Chemistry, Osmania University, Hyderabad 5000007, A.P., India.     

Carbon Nanotubes Fed on “Carbs”: Coating of Single‐Walled Carbon Nanotubes by Dextran Sulfate

A facile and easily reproducible technique for assembling biohybrid nanoparticles is a core feature that is highly desired for biomedical applications, considering the nature and limited lifespan of the biopolymers used. Here we show a simple and effective method to enfold single‐walled carbon nanotubes (SWNTs) using an anionic polysaccharide, dextran sulfate. After their interactions, SWNTs were rendered dispersible in aqueous solution and were shortened and unbundled to their basic dimension. Atomic force microscopy analysis was extensively employed to elucidate the mechanism of their interfacing. This biohybrid nanoparticle holds promise for biological and biomedical applications due to the synergistic unique properties of SWNTs and dextran sulfate.

     

Optimal dynamic multi-attribute hashing for range queries

This paper examines a partial match retrieval scheme which supports range queries for highly dynamic databases. The scheme relies on order preserving multi-attribute hashing. In general, designing optimal indexes is NP-hard. Greedy algorithms used to determine the optimal indexes for simple partial match queries are not directly applicable because there are a larger number of queries to consider in determining the optimal indexes. In this paper we present heuristic algorithms which provide near-optimal solutions. The optimisation scheme we propose can be used to design other dynamic file structures such as the grid file, BANG file and multilevel grid file to further enhance their retrieval performance taking into consideration the query distribution.     

Multi-attribute hashing with multiple file copies for high performance partial-match retrieval

The average cost for answering partial-match queries can be dramatically reduced by storing multiple copies of the data, each with a different clustering. We analyse the cost benefits (in terms of page accesses) of this arrangement and present heuristic algorithms for determining a near-minimal-cost file organisation for a given probability distribution of queries. We also show how constraining the range of values for specific attributes affects the usefulness of maintaining multiple copies.     

Alternative Total Synthesis of (−)-Galanthamine Hydrobromide

Abstract

An alternative total synthesis of (?)-galanthamine (1) hydrobromide, employing ecofriendly amidation, oxidative coupling, and classical resolution strategies is accomplished.     

Development and Validation of TLC Method for Analysis of Stresroak Premix

JPC – Journal of Planar Chromatography – Modern TLC - With the realization of the growing popularity and demand for phytopharmaceuticals, standardization is becoming a mandatory part of...