Site-specific modification of the 5"-terminal fragment of PGY1/MDR1 gene mRNA by reactive conjugates of antisense oligonucleotides

The site-specific modification of the 5"-terminal fragment of PGY1/MDR1 mRNA by oligodeoxyribonucleotide conjugates bearing residues of bleomycin A₅ (Blm), cobalt(ii) tetracarboxyphthalocyanine (Phcn), 4-[N-(2-chloroethyl)-N-methylamino]benzylamine (RCl), or perfluoroarylazide (Az) was studied. Conjugates of oligonucleotides complementary to the RNA sequences 123—138 and 155—166 selectively modify RNA in the vicinity of these regions. The highest efficacy (up to 50%) was achieved in reactions with alkylating and perfluoroarylazide conjugates of oligonucleotides. Conjugates of perfluoroarylazide with 2"-O-modified oligonucleotides are much more efficient than analogous conjugates with oligodeoxyribonucleotides (extents of RNA modification are 40—50% and 20%, respectively).     

Finite-difference solution of the problem of optimizing the speed of heating of inhomogeneous thermoelastic bodies by internal heat sources

We consider the problem of optimal control of one-dimensional nonstationary temperature regimes of inhomogeneous bodies with respect to speed of action with restrictions on the control and normal thermoelastic stresses ₂₂ of maximum absolute value (in cylindrical and spherical coordinates the circumferential stresses .Translated fromMatematicheskie Metody i Fiziko-Mekhanicheskie Polya, Issue 34, 1991, pp. 61–65.     

Stability of Defectless Structures of Titanium Monoxide at High Pressures

JETP Letters - Titanium monoxide with the basis crystal structure B1 is of interest because of an anomalously high concentration of vacancies and diverse effects of atom–vacancy ordering. It...     

Ant algorithms for scheduling computations in data centers

An ant colony algorithm is considered for the problem ofmapping requests onto physical resources of data centers. Results from an experimental study of the properties of the algorithm are presented, and it is compared to algorithms that combine greedy strategies and limited searches.     

Asymmetric Michael reaction between aldehydes and nitroalkanes promoted by pyrrolidine-containing C2-symmetric organocatalysts

Russian Chemical Bulletin - Bifunctional C2-symmetric organocatalysts derived from chiral 1,2-diaminoethanes and (S)-2-aminomethylpyrrolidine were fi rst used for promoting the asymmetric Michael...     

STRUCTURE,MAGNETIC, AND MAGNETOCALORIC PROPERTIES OF SUBMICRONIC YTTRIUM IRON GARNET PARTICLES

Journal of Structural Chemistry - Scanning electron microscopy, X-ray diffraction, Raman and Mössbauer spectroscopies, field and temperature dependences of magnetic saturation and...     

Renormalization Group Analysis of Models of Advection of a Vector Admixture and a Tracer Field by a Compressible Turbulent Flow

Theoretical and Mathematical Physics - Using a quantum field theory renormalization group, we consider models of advection of a vector field and a tracer field by a compressible turbulent flow....