Synthesis of Selenium(0) and Zinc(II) Biomolecules in Nano-Structured Forms as New Antioxidant Agents: Chemical and Biological Studies

Russian Journal of General Chemistry - In this paper, two new complexes of selenium caffeine, [Se(Caf)4], and zinc α-tocopherol, [Zn(α-Tpl)2(NO3)2], are synthesized. The structures of...     

Synthesis,spectroscopic, thermal,free radical scavenging ability,and antitumor activity studies of cobalt(II) metformin complex

New [Co(Mfn-HCl)₂(NO₃)₂] · 6H₂O complex has been synthesized and characterized using microanalytical, molar conductance, spectroscopic (IR and UV-Vis), effective magnetic moment, and thermal analyses. The infrared spectroscopic results data received from the comparison between free Mfn · HCl ligand and its cobalt(II) complex proved that Metformin forms complex with cobalt(II) ions as a bidentate ligand through its two imino groups. The antioxidant activity of the Mfn · HCl and Co(II)-2Mfn · HCl complex were evaluated by using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging method. Antitumor activity for Mfn · HCl ligand and its cobalt(II) complex was determined using Ehrlich Ascites carcinoma cell (EACC) line. It has been shown that the Co(II)-Mfn · HCl complex is much more effective as free radical scavenger and has higher antitumor activity than the free Mfn · HCl ligand.     

Synthesis,spectroscopic, and molar conductance characterization of selenium(IV) vitamin B6 complex as prospective antioxidant agent

Selenium(IV) complex of vitamin B₆ has been prepared using Se(IV) tetrachloride and characterized using spectroscopy (IR, UV-Vis, H NMR), molar conductance measurements, thermal analysis (DTA and TGA) and SEM imaging. Micro-analytical and spectral data show that the formed selenium(IV) complex is 1 : 2 (Se : vitamin B₆) molar ratio. Vitamin B6 and its selenium complex were screened for in vitro antioxidant activity. The complex exhibited stronger antioxidant activity in 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical assay compared to the free vitamin B6 ligand.