Investigation and comparison of biological effects of regioselectively synthesized thiazole derivatives

In this study, anticancer, antibacterial (against hospital-isolated antibiotic-resistant Escherichia coli strains), antifungal, and antioxidant effects of synthesized heterocyclic compounds 5 and 7 containing thiazole core were examined. Cytotoxicity testing was utilized against MCF-7 breast cancer cells via MTT cell viability assay. Antibacterial and antifungal activities were checked out according to Clinical and Laboratory Standards Institute (CLSI) guidelines, and antioxidant properties were evaluated through scavenging 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals. Results showed the viability of breast cancer cell lines was reliant on concentration of heterocycles and time of incubation. Synthetic compounds exhibited excellent antibacterial and antifungal properties base on their minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentration (MFC) values as well as high antioxidant activities according to their IC₅₀ values. Higher anticancer and antibacterial properties were observed with compound 7; on the contrary, thiazole 5 had better antioxidant effects. They can be introduced as potent antimicrobial, antioxidant, and anticancer agents.     

Effect of Crystallization Kinetics on Microstructure and Charge Transport of Polythiophenes

We have examined the effects of crystallization kinetics of poly(3‐hexylthiophene) and poly[2,5‐bis(3‐hexadecylthiophen‐2‐yl)thieno(3,2‐b)thiophene] on microstructure and charge transport. Rapid crystallization increases the density of tie molecules in polythiophenes. As a consequence, ordered regions are better connected resulting in higher charge carrier mobilities. Our results suggest that controlling the crystallization kinetics might be an important factor for maximizing the charge mobility in semicrystalline polythiophene thin films.     

Experimental investigation of heat transfer and exergy loss in heat exchanger with air bubble injection technique

Journal of Thermal Analysis and Calorimetry - The main aim of this study is to evaluate thermal performance and exergy analysis of a shell-and-tube heat exchanger with a new technique called air...     

Inverse vibration problem for un-damped 3-dimensional multi-story shear building models

Various researchers have contributed to the identification of the mass and stiffness matrices of two dimensional (2-D) shear building structural models for a given set of vibratory frequencies. The suggested methods are based on the specific characteristics of the Jacobi matrices, i.e., symmetric, tri-diagonal and semi-positive definite matrices. However, in case of three dimensional (3-D) structural models, those methods are no longer applicable, since their stiffness matrices are not tri-diagonal. In this paper the inverse problem for a special class of vibratory structural systems, i.e., 3-D shear building models, is investigated. A practical algorithm is proposed for solving the inverse eigenvalue problem for un-damped, 3-D shear buildings. The problem is addressed in two steps. First, using the target frequencies, a so-called normalized eigenvector matrix, which is a banded matrix containing the information related to the frequencies and mode shapes of the target structural system, is determined. In this regard, similar to the solution of inverse problem for 2-D shear building structural models in which an auxiliary structure is constructed by adding constraints (or springs) to the original system, three auxiliary structures are proposed to solve the problem for 3-D cases. In the second step, the normalized eigenvector matrix is utilized to obtain the normalized stiffness matrix; in turn, this matrix is decomposed into the stiffness and mass matrices of the system. Finally, a numerical example is presented to demonstrate the efficiency of the proposed algorithm in determining the mass and stiffness matrices of a 3-D structural model for a given set of target vibrational frequencies.     

Non-phosgene route to unsymmetrical ureas from N-Cbz-α-amino acid amides

A convenient method toward the synthesis of α-amino acid-derived unsymmetrical ureas 2 is described herein. This route involves an interesting rearrangement of amides of N-Cbz-α-amino acids 1, which presumably entails the intermediacy of hydantoins that is followed by hydrolysis to afford unsymmetrical ureas 2 in quantitative yields and high purity.     

Chemoselective Synthesis of Functionalized 2,5-Dihydro-2-thioxo-1H-imidazoles from 5,5-Diarylthiohydantoins and Activated Acetylenes

Stable crystalline phosphorus ylides are obtained in excellent yields from the 1:1:1 addition reaction between 5,5-diarylthiohydantoins and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine. These phosphoranes undergo a smooth intramolecular Wittig reaction followed by an electrocyclic ring opening to produce dialkyl 2-(2,5-dihydro-5,5-diaryl-2-thioxo-1H-imidazol-4-yl)but-2-enedioates in good yields.     

One-pot synthesis of functionalized ��-acyloxythioamides from N-Protected a-amino acids as an acid component in the passerini reaction in an ionic liquid

N-Protected ??-amino acids, prepared from benzoyl chlorides, KSCN and ??-amino acids, were used as the acid component in the Passerini reaction, in an ionic liquid, to produce functionalized ??-acyloxythioamides in 59?C95% yields. The work-up procedure was fairly simple and the products did not require further purification.     

Direct measurements of exciton diffusion length limitations on organic solar cell performance

Through a combination of X-ray scattering and energy-filtered electron microscopy, we have quantitatively examined the relationship between the mesostructure of the photoactive layer and device performance in PBTTT/PC(71)BM solar cells. We can predict device performance from X-ray structural data through a simple morphological model which includes the exciton diffusion length.