Synchronization in supply chains: implications for design and management

Supply chain management literature calls for coordination between the different members of the chain. Materials should be moved from one supplier to the next according to a just-in-time schedule. In this paper, we show that for many supply chain configurations, complete synchronization will result in some members of the chain being ‘losers’ in terms of cost. We develop an algorithm for optimal synchronization of supply chains and provide some guidelines for incentive alignment along the supply chain. In developing the model, we use the economic delivery and scheduling problem model and analyze supply chains dealing with single and multiple components. For single-component supply chains, we derive a closed-form expression for the optimal synchronized cycle time. For multi-component supply chains, we develop an algorithm for finding the optimal synchronized cycle time. We test the performance of the algorithm and show that it provides optimal solutions for a wide range of problems. We illustrate the models with numerical examples.     

A Note on the Newsboy Problem with an Emergency Supply Option

In this note, we solve a newsboy problem with an emergency supply option. We solve the new problem with the objectives of maximizing expected profit and maximizing the probability of achieving a target profit. The new optimal order quantity is smaller than the optimal order quantity without emergency supply.     

Can piracy lead to higher prices in the music and motion picture industries?

Piracy of copyrighted goods has received increased attention in the literature. Much of this research has focused on pricing policies, protection against piracy, and governmental policies in the software industries. In this paper, we focus on pricing policies of producers in the music and motion picture industries. Exact analytical results are difficult to obtain; therefore, we develop an approximating function of the cumulative demand. This enables us to obtain closed-form expressions for the optimal price. Our results show that the existence of piracy in these industries and the lack of positive network externalities may cause monopolists to charge higher prices to optimize profits. These prices increase with increases in the speed of piracy and longer product lifecycles. We demonstrate the accuracy of our demand approximation function using a numerical experiment. We show how a two-price strategy and dual distribution channels may help in reducing the negative effects of piracy. We perform some numerical sensitivity analysis and provide managerial insights.     

Pareto analysis of supply chain contracts under satisficing objectives

Supply chain coordination has become critical to firms as increased pressure is placed on them to improve performance. We evaluate the performance of Push, Pull, and Advance-purchase discount (APD) contracts in a manufacturer-retailer supply chain where one or both firms have a satisficing objective of maximizing the probability of achieving a target profit. We identify the resulting operational modes of the supply chain and potential conflicts over the preferred contracts under the Push, Pull, and APD contracts. When both firms are satisficing, conflict over the preferred contract arises when the manufacturer has an ambitious profit target or the retailer has a low profit target. We show that the Push contract can result in a large decrease in the expected profit of a risk-neutral manufacturer when the retailer maximizes the probability of achieving her maximum expected profit. We find that a modified buy-back and profit guarantee contracts can provide significant Pareto improvement over Push or APD contracts when the manufacturer is risk-neutral and the retailer is satisficing, while revenue-sharing contracts cannot. In contrast, revenue sharing and modified buy-back contracts are Pareto dominant under certain conditions when the manufacturer is satisficing and the retailer is risk-neutral.     

Analysis of the effectiveness of manufacturer-sponsored retailer gift cards in supply chains

Some manufacturers sponsor “free” retailer gift cards to be given to consumers who purchase their products. These gift cards are paid for by the manufacturer and are redeemable on all products at the retailer. We develop a model of such a supply chain. We analyze cases in which the gift cards’ redemption rate is constant or increasing in gift card value. The results indicate that in addition to the redemption rate and consumers’ valuation for gift card dollars, the profitability of manufacturer-sponsored gift cards depends on the average gross margin of the retailer and the type of purchases consumers make with gift cards. Furthermore, we show that under certain conditions, free gift cards will increase the expected profits of the retailer and manufacturer as well as decrease the retail price of the product. These conditions include a retailer with large average gross margin and consumers using gift cards to purchase products they would not buy with cash otherwise. Furthermore, all consumers, including those who do not redeem the gift card, are more likely to benefit from a reduced retail price when their probability of redeeming the gift card after purchase is equal to their estimated redemption probability at purchase time. We show the conditions under which gift cards are more profitable than cash mail-in rebates. We develop an incentive scheme to improve the performance of supply chains with gift cards.     

Copper and iron interactions with angiotensin-converting enzyme inhibitors. A study by fast-atom bombardment tandem mass spectrometry

Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen. Copyright 1999 John Wiley & Sons, Ltd.     

ESI‐MS/MS of expanded porphyrins: a look into their structure and aromaticity

Electrospray mass spectrometry/mass spectrometry was used to investigate the gas‐phase properties of protonated expanded porphyrins, in order to correlate those with their structure and conformation. We have selected five expanded meso‐pentafluorophenyl porphyrins, respectively, a pair of oxidized/reduced fused pentaphyrins (22 and 24 π electrons), a pair of oxidized/reduced regular hexaphyrins (26 and 28 π electrons) and a regular doubly N‐fused hexaphyrin (28 π electrons). The gas‐phase behavior of the protonated species of oxidized and reduced expanded porphyrins is different. The oxidized species (aromatic Hückel systems) fragment more extensively, mainly by the loss of two HF molecules. The reduced species (Möbius aromatic or Möbius‐like aromatic systems) fragment less than their oxidized counterparts because of their increased flexibility. The protonated regular doubly fused hexaphyrin (non‐aromatic Hückel system) shows the least fragmentation even at higher collision energies. In general, cyclization through losses of HF molecules decreases from the aromatic Hückel systems to Möbius aromatic or Möbius‐like aromatic systems to non‐aromatic Hückel systems and is related to an increase in conformational distortion. Copyright © 2016 John Wiley & Sons, Ltd.     

Correlation between chemical composition and antibacterial activity of essential oils from fifteen Eucalyptus species growing in the Korbous and Jbel Abderrahman arboreta (North East Tunisia)

The essential oils of fifteen Eucalyptus species harvested from the Jbel Abderrahman and Korbous arboreta (North East Tunisia) were screened for their antibacterial activities by the agar disc diffusion method. Eighteen major components as identified by GC/FID and GC/MS were selected for a study of the chemical and biological activity variability. The main one was 1,8-cineole, followed by spathulenol, trans-pinocarveol, α-pinene, p-cymene, globulol, cryptone, β-phellandrene, viridiflorol, borneol, limonene and isospathulenol. The chemical principal component analysis identified five species groups and subgroups, where each group constituted a chemotype, however that of the values of zone diameter of the inhibition (zdi) identified six groups of Eucalyptus oils, characterized by their antibacterial inhibition ability. The strongest activity was shown by E. platypus oil against Enterococcus faecalis and by E. lamannii oil against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. A correlation between the levels of some major components and the antibacterial activities was observed.