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Andhe V. Narender Reddy Charles Y. Fiakpui David P. Czajkowski Paul Spevak Jadwiga Kaleta Ronald G. Micetich Samarendra N. Maiti 《Chemistry of Heterocyclic Compounds》1998,34(11):1289-1295
A new series of 2-spiro(2,2-diphenylcyclopropane) cephalosporin sulfones was synthesizes as potent human leukocyte elastase inhibitors.SynPhar Laboratories Inc., #2 Taiho Alberta Centre, 4290-91A Street, Edmonton, Canada T6R 5V2. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1517–1523, November, 1998. 相似文献
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The conformations of unsolvated Ac-A14KG3A14K + 2H+ (Ac = acetyl, A = alanine, K = lysine, G = glycine) have been examined by ion mobility measurements and molecular dynamics simulations. This peptide was designed as a model helix-turn-helix motif. It was found to adopt three distinct geometries which were assigned to an extended helical conformation which is only stable at low temperatures (<230 K), a relatively high energy but metastable structure with exchanged lysines, and a coiled-coil. The coiled coil (which consists of an antiparallel arrangement of two helical alanine sections linked by a flexible glycine loop) is the dominant conformation. For temperatures >350 K, the experimental results indicate the helices uncouple and the loop randomizes. From equilibrium constants determined for this helix coupling right arrow over left arrow uncoupling transition, we found DeltaH degrees = -45 kJ mol-1 and DeltaS degrees = 114 J K-1 mol-1. -DeltaH degrees is essentially the enthalpy change for docking the two helices together while DeltaS degrees is essentially the entropy change for freeing up the glycine loop. 相似文献
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[reaction: see text] A fluorous analogue of Lawesson's reagent for thionation of carbonyl compounds has been developed and its use demonstrated on a series of amides, esters, and ketones. The separation of the Lawesson's reagent-derived byproducts can be achieved by a simple fluorous solid-phase extraction. 相似文献
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Potential Analysis - We study the quenched long time behaviour of the survival probability up to time t, $\mathbf {E}_{x}\left [e^{-{{\int }_{0}^{t}} V^{\omega }(X_{s})\mathrm {d}s}\right ],$ of a... 相似文献
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Katharina Kaleta Helmar Görls Wolfgang Imhof 《Journal of organometallic chemistry》2009,694(23):3800-2713
N,N′-(4-methyl-4H-1,3,4-oxadiazine-5,6-diylidene)-bis-aniline derivatives react with Fe2(CO)9 to give dinuclear iron carbonyl complexes. One of the iron atoms is bonded symmetrically to both exocyclic imine nitrogen atoms. The second iron atom shows a side-on coordination towards the CN bond next to the oxadiazine oxygen atom. In addition, the iron atoms are connected via a metal metal bond. The same oxadiazine derivatives produce chiral spiro-lactams in a ruthenium catalyzed formal [2+2+1] cycloaddition reaction with carbon monoxide and ethylene. 相似文献
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When a time harmonic electromagnetic wave impinges on a slaba certain portion of the wave creates heat within the slab throughdipolar and ohmic heating. The electrical and thermal propertiesof the material dictate the dynamical nature of the heatingprocess, as well as the steady-state temperature profile. Thematerial considered here is a slab of fluid. We consider thecase where the fluid is bounded by thin rigid layers of transparentmaterial. The steady-state heating profile governs the typesof convective motions that can occur and also affects the stabilitycharacteristics of temperature, pressure and velocity perturbationsintroduced in the slab. The main objective here is to examinesuch stability characteristics, initially in the linear regime.Both rigid-rigid and rigid-free configurations are considered. 相似文献
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Highly efficient fluorous tagging methodology was developed based on catalytic 1,3-dipolar cycloaddition as the key step. 相似文献
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A reversed-phase high-performance liquid chromatography method with gradient elution was developed for the determination of the caffeic, p-coumaric, and ferulic acids in propolis concentrates. Solid-phase extraction on an RP18 column was applied for preliminary purification, and chromatographic separation was performed on 100 RP18e Lichrospher column of particle size 5 microm. The mobile phase was obtained by mixing in appropriate ratios 0.03 mM NaH2PO4, acidified with H3PO4 up to pH = 3.0, with acetonitrile to obtain a gradient in the elution process. Spectrophotometric detection was conducted at 320 nm. Under the established conditions, the method featured high sensitivity, good precision, and comparability of results, as proven by method validation and statistical analysis of the obtained results. The limits of detection were 0.315, 0.325, and 0.695 microg/mL for caffeic, p-coumaric, and ferulic acids, respectively. The corresponding recovery values were 98.14, 101.05, and 99.42% and the linearity ranges from 1.31 to 99.18 microg/mL, 1.52 to 119.16 microg/mL, and 2.42 to 184.14 microg/mL. The precision of the method was expresed by relative standard deviation values that did not exceed 3%. It was also shown that the propolis concentrates under examination had similar antibacterial activity against Staphylococcus aureus ranging from 119.8 to 124.3 microg/mL, contrary to model mixtures that showed no antibacterial activity. 相似文献
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Improved capillary electrophoretic separation of nine (fluoro)quinolones with fluorescence detection for biological and environmental samples 总被引:1,自引:0,他引:1
A capillary electrophoretic method has been developed for the separation of nine (fluoro)quinolones. Detection is done by fluorescence measurement with broad wavelength band excitation between 240 and 400 nm. Best separation is achieved in a carrier electrolyte containing 50 mM H3PO4 adjusted to pH 7.55-acetonitrile (60:40, v/v). Detection limits are in the low microgl(-1) range. The suitability to real samples has been demonstrated by analyzing blood samples and surface water samples. Sample preconcentration and sample clean-up can easily be done by solid-phase extraction. Different phases based on alkyl- or phenyl-modified silica as well as on polymers have been investigated for this purpose. The method should also be useful for determination of residues of (fluoro)quinolones in food or other matrices. 相似文献