Spectrophotometric Quantitation of Fluoxetine Hydrochloride Using Benzoyl Peroxide and Potassium Iodide

 Fluoxetine hydrochloride reacts with benzoyl peroxide and potassium iodide, after heating for 1 min at 30 °C, to give a blue colour having maximum absorbance at 570 nm. The reaction is selective for fluoxetine with 0.01 mg/mL as visual limit of quantitation and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.1 mg/10 mL to 2.0 mg/10 mL of fluoxetine and the relative standard deviation is 0.68%. The qualitative assessment of tolerable amounts of other drugs is also studied. Received September 21, 1998. Revision September 10, 1999.     

Demicompactness Results for Strongly Continuous Semigroups,Generators and Resolvents

Let \((U(t))_ {t\ge 0}\) be a strongly continuous semigroup of bounded linear operators on a Banach space X and B be a bounded operator on X. In this paper, we develop some aspects of the theory of semigroup for which U(t)B (respectively, BU(t), BU(t)B) is demicompact for some (respectively, every) \(t>0\). In addition, we study the demicompactness of similar, subspace and product semigroups. We also investigate the demicompactness of the resolvent. We close this paper by giving some conditions guaranteeing the demicompactness of a generator of a strongly continuous semigroup in a Hilbert space.     

Computational Approaches for the Design of Novel Anticancer Compounds Based on Pyrazolo[3,4-d]pyrimidine Derivatives as TRAP1 Inhibitor

In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. The 3D QSAR study showed a statistically significant model with R² = 0.96 and Q² = 0.57. Leave one out (LOO) cross-validation (R² CV = 0.58) was used to validate the QSAR model. The molecular docking study showed maximum XP docking scores (−11.265, −10.532, −10.422, −10.827, −10.753 kcal/mol) for potent pyrazole analogs (42, 46, 49, 56, 43), respectively, with significant interactions with amino acid residues (ASP 594, CYS 532, PHE 583, SER 536) against TRAP1 kinase receptors (PDB ID: 5Y3N). Furthermore, the docking results were validated using the 100 ns MD simulations performed for the selected five docked complexes. The selected inhibitors showed relatively higher binding affinities than the TRAP1 inhibitor molecules present in the literature. The ZINC database was used for a virtual screening study that screened ZINC05297837, ZINC05434822, and ZINC72286418, which showed similar binding interactions to those shown by potent ligands. Absorption, distribution, metabolism, and excretion (ADME) analysis showed noticeable results. The results of the study may be helpful for the further development of potent TRAP1 inhibitors     

Lamb wave propagation using Wave Finite Element Method

Some of the available techniques for Lamb wave propagation simulation are the Finite Element Method (FEM), the Boundary Element Method and the Finite Difference Method. The FEM is the best method when complex damage, geometry or boundary is involved. However, high Lamb wave frequency requires very small element size thus high computational cost in FEM analysis. By using the existence of periodicity in plates, an attempt to reduce this computational cost is done using Wave FEM. The applicability of this method to model Lamb wave propagation in plate is first assessed in this paper for the 1-D wave propagation and compared with FEM explicit method. (© 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)     

Spectrophotometric Determination of Prochlorperazine Maleate in Pure and Pharmaceutical Preparations

 Prochlorperazine maleate reacts with 1-naphthylamine and sodium nitrite, after heating for 110 s at 80 °C to give an orange red colour having maximum absorbance at 460 nm. The reaction is selective for prochlorperazine maleate with 0.01 mg/mL as visual limit of quantitation and provides a basis for a new spectrophotometric determination. The colour reaction obeys Beer’s law from 0.01 mg/10 mL to 0.33 mg/10 mL of prochlorperazine maleate and the relative standard deviation is 0.68%. The quantitative assessment of tolerable amounts of other drugs is also studied. Received September 22, 2000. Revision June 19, 2001     

Thermotropic homopolyesters. I. The preparation and properties of polymers based on 4,4′-dihydroxybiphenyl

A homologous series of polyesters was prepared from 4,4′-dihydroxybiphenyl and dibasic acids having 5-12 methylene units. The mesophases formed at elevated temperatures were studied by differential scanning calorimetry and polarized light microscopy. This family exhibits an unusual odd-even effect when the transition temperatures are plotted as a function of the number of methylene units in the dibasic acid. Not only do the points for odd and even members fall on different curves, but the odd members exhibit a nematic phase over a very short temperature interval, while the even members form a highly ordered smectic phase. For both the odd and even series, the transition temperatures are significantly depressed when the inherent viscosity falls below 0.2 dL/g. The largest depression occurs for the crystal melting transition, so that polymers of low η_inh show anisotropic and biphasic regions over wider temperature ranges. A copolymer formed from an equimolar mixture of sebacic and chiral (+)-3-methyl adipic acid forms a cholesteric phase. Evidently copolymerization destabilizes the smectic phase which would have been expected. The results are discussed in terms of existing theory.     

A Polyester Forming a Thermotropic Cholesteric Phase

Mesomorphic polyesters were synthesized from 4, 4′-dihydroxy-α-methylstilbene and adipic acid (P-6) or (+)-3-methyl adipic acid (P-6M). P-6 forms a thermotropic nematic phase and P6-M a thermotropic cholesteric phase. The nematic phase of P-6 could easily be identified by optical microscopy. For both polymers we observed a biphasic region in which the isotropic and liquid crystalline phases coexist. Bright colors were obtained by increasing the pitch of P6-M by admixture with either a low molecular weight nematogen or with polymer P-6, and also by synthesizing a copolymer containing the two dibasic acids. The copolymeric cholesteric phase, which is stable between 199 and 282[ddot]C, had a predominately planar texture, and these features could be retained in the solid state by quenching to produce a film having a deep blue color at room temperature. The role of the degree of polymerization upon the development of organization, and parameters, of the mesophase is discussed.     

Synthesis of Novel Symmetric Porphyrin Schiff Base Dimers by Solid–Liquid Reaction Methodology

A new convenient solid–liquid condensation reaction procedure for the synthesis of novel asymmetric and symmetric meso‐tetraarylporphyrin and metalloporphyrin Schiff bases is reported. The condensation reaction between β‐formyl porphyrin or metalloporphyrins and aromatic amines was carried out at solid–liquid interface by using neutral alumina powder as a solid support for β‐formyl porphyrin or metalloporphyrins and absolute ethanol as the carrier solvent for aromatic amines. Six different asymmetric porphyrin/metalloporphyrin Schiff bases were synthesized via solid–liquid interface reaction methodology. The same solid–liquid synthetic methodology was applied for the synthesis of six novel symmetric Schiff base porphyrin/metalloporphyrin dimers. The comparison of UV–visible spectra of porphyrin Schiff base monomers and dimers revealed that some degree of electronic perturbation has occurred upon dimerization as the Soret bands of the monomers underwent peak broadening along with red shifts. Column chromatography and crystallization were used to purify the compounds. Fourier transform infrared, UV–visible, elemental analysis, ¹H NMR, and mass spectrometry were used to characterize the newly synthesized compounds.