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In this research, copper oxide nanoparticles modified carbon paste electrode was developed for the voltammetric determination of lidocaine. The square wave voltammogram of lidocaine solution showed a well-defined peak between +0.5 and +1.5 V. Instrumental and chemical parameters influencing voltammetric response were optimized by both one at a time and Box–Behnken model of response surface methodology. The results revealed that there was no significant difference between two methods of optimization. The linear range was 1–2500 μmol L~(-1)(Ip= 0.11 C_(LH)+ 17.38, R~2= 0.999). The LOD and LOQ based on three and ten times of the signal to noise(S/N) were 0.39 and 1.3 μmol L~(-1)(n = 10),respectively. The precision of the method was assessed for 10 replicate square wave voltammetry(SWV)determinations each of 0.05, 0.5 and 1 μmol L~(-1) of lidocaine showing relative standard deviations 4.1%,3.7% and 2.1%, respectively. The reliability of the proposed method was established by application of the method for the determination of lidocaine in two pharmaceutical preparations, namely injection and gel. 相似文献
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