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Mehmood A Malik A Anis I Khan PM Riaz M Makhmoor T Choudhary MI 《Natural product letters》2002,16(6):371-376
Two new oleanane triterpenes; 2alpha,3alpha,24-trihydroxyolean-12-ene-28,30-dioic acid ([structure: see text]) and 2alpha,3alpha,24,28-tetrahydroxyolean-12-ene ([structure: see text]) have been isolated from the roots of Atropa acuminata. Anti-oxidant p-hydroxyphenethyl trans-ferulate ([structure: see text]), beta-sitosterol-3-O-beta-D-glucopyranoside ([structure: see text]) and oleanolic acid ([structure: see text]) have also been reported for the first time from this species. The structures were determined by spectroscopic studies including 2D-NMR. 相似文献
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Riaz N Anis I Malik A Ahmed Z Aziz-ur-rehman Muhammad P Nawaz SA Choudhary MI 《Chemical & pharmaceutical bulletin》2003,51(3):252-254
Paeonins A and B, new monoterpene galactosides have been isolated from the chloroform-soluble fraction of the roots of Paeonia emodi and showed potent lipoxygenase inhibitory activity. The structures of 1 and 2 have been assigned on the basis of spectral analysis including one- and two-dimensional NMR techniques. 相似文献
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Afaq Shagufta Khan Sadia Kazmi Mehdi Hassan Fatima Itrat Malik Abdul Inamullah Farah Farhad Zahid Abbas Tanveer Tareen Rasool Bakhsh 《Chemistry of Natural Compounds》2021,57(2):269-273
Chemistry of Natural Compounds - Armatans A (1) and B (2), new isoflavans, have been isolated from the EtOAc-soluble fraction of the MeOH extract of Colutea armata Hemsl. & Lace, along with... 相似文献
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Caragisides A–C ( 1 – 3 , resp.), three new isoflavone glucosides, were isolated from the BuOH sub‐fraction of the EtOH extract of the whole plant of Caragana conferta, along with ononoside ( 4 ), reported for the first time from this species. The structures of the new compounds were elucidated by spectroscopic techniques including MS and 2D‐NMR spectroscopy. Compounds 1 – 3 showed significant inhibition of platelet aggregation. 相似文献
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Ahmad I Nawaz SA Afza N Malik A Fatima I Khan SB Ahmad M Choudhary MI 《Chemical & pharmaceutical bulletin》2005,53(8):907-910
Onosmins A (1) and B (2), lipoxygenase inhibitors, have been isolated from Onosma hispida. Their structures were established as 2-[(4-methylbenzyl)amino]benzoic acid (1) and methyl 2-[(4-methylbenzyl)amino]benzoate (2) through spectroscopic studies, including 2D-NMR. The known compounds apigenin (3), 6,4'-dimethoxy-3,5,7-trihydroxyflavone (4), 6,7-dimethoxy-3,5,4'-trihydroxyflavone (5) and apigenin 7-O-beta-D-glucoside (6) are also reported for the first time from this species. Compounds (1) and (2) inhibited lipoxygenase (LOX, EC 1.13.11.12) enzyme in a concentration-dependent fashion with IC50 values of 24.0 and 36.2 microM, respectively. Lineweaver-Burk as well as Dixon plots and their secondary replots indicated that the nature of inhibition was purely a non-competitive type, with K(i) values 22.0 microM and 31.1, respectively. 相似文献
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Zaheer Ahmad Itrat Fatima Sajid Mehmood Rehana Ifzal Abdul Malik Nighat Afza 《Helvetica chimica acta》2008,91(1):73-78
Three new 20,24‐epoxydammarane triterpenes, santolins A–C ( 1 – 3 ), were isolated from the AcOEt‐soluble fraction of the MeOH extract of Salvia santolinifolia (whole plant). Their structures were assigned based on 1H‐NMR, 13C‐NMR (DEPT), and 2D‐NMR analyses, in combination with HR‐MS experiments and comparison with literature data of related compounds. 相似文献
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Riaz N Anis I Aziz-ur-Rehman Malik A Ahmed Z Muhammad P Shujaat S Atta-ur-Rahman 《Natural product research》2003,17(4):247-251
Emodinol, a new oleane type triterpene, has been isolated from the chloroform soluble fraction of Paeonia emodi. The structure 1beta, 3beta, 23-trihydroxyolean-12-en-28-oic acid 1 has been assigned on the basis of spectral studies including 2D NMR. It showed significant beta-glucuronidase inhibitory activity. In addition benzoic acid and 3-hydroxybenzoic acid have also been reported for the first time from this species. 相似文献
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Azhar Mahmood Itrat Fatima Shaheen Kosar Rehana Ahmed Abdul Malik 《Magnetic resonance in chemistry : MRC》2010,48(2):151-154
Prunusins A (1) and B (2), the new C‐alkylated flavonoids, have been isolated from the seed kernels of Prunus domestica. Their structures were assigned from 1H and 13C nuclear magnetic resonating spectra, DEPT and by correlation spectroscopy, HMQC and HMBC experiments. 3, 5, 7, 4′‐Tetrahydroxyflavone (3) and 3, 5, 7‐trihydroxy‐8, 4′‐dimethoxyflavone (4) have also been reported from this species. Both compounds (1) and (2) showed significant antifungal activity against pathogenic fungus Trichophyton simmi. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献