Book Review

Structural Chemistry -     

Book Reviews

Unsigned book reviews are by the Book Review Editor.     

Book reviews

Please forward books for review to the book review editor: Magdolna Hargittai, Structural Chemistry Research Group of the Hungarian Academy of Sciences, Eötvös University, H-1431 Budapest, Pf. 117, Hungary     

Synthesis of cephalosporins carrying isoxazolyl acetamido and related side chains

Starting from 3,5-dimethylisoxazole the carboxylic acids I and V, the amino acids VIII (L-) and IX (D-), and the ureido acids X (L-) and XI (D-) were prepared, which were used for the synthesis of the new cephalosporins XVIIb, XXa-c (L-), and XXIb (D-). Thein vitro antibacterial activity of these semi-synthetic antibiotics was studied. The resorption of XVIIb was investigated in mice.Research Group for Antibiotics of the Hungarian Academy of Sciences, H-4010 Debrecen, P.O. Box 70, Hungary. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1524–1535, November, 1998.     

Molecular structure of 4,4′-sulfandiyl-bis-thiophenol from electron diffraction

The molecular structure of 4,4′-sulfanidyl-bis-thiophenol (C₁₂H₁₀S₃) has been determined by gas electron diffraction. Assuming identical geometry and D_2h local symmetry for ---SC₆H₄S--- moieties, the following bond lengths (r_g) and bond angles were obtained: C---H = 1.101 ± 0.005, S---H = 1.388 ± 0.019, (C---C)_mean = 1.400 ± 0.003, (S---C)_mean = 1.778 ± 0.004 Å, C_ar---S---C_ar = 103.5 ± 1.3, C---C(S)---C = 120.4 ± 0.3, C(H)---C(H)---H = 119.1 ± 0.9 and C---S---H = 94.6 ± 3.1°. Two ratational forms were found to reproduce the experimental data, characterized by dihedral angles of the benzene rings with respect to the C_arSC_ar plane; ₁ = 67.8 ± 2.0°, ₂ = 4.5 ± 7.2°, and ₁ = 69.4 ± 2.0δ, ₂ = −26.6 ± 7.1°. Identical signs of ₁ and ₂ indicate that the two benzene rings are rotated in the same direction about the respective S_central---C axes.