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Tibor Rozsa Mihaela Duma Laurian Vlase Ioana Ionuţ Adrian Pîrnău Brînduşa Tiperciuc Ovidiu Oniga 《Journal of heterocyclic chemistry》2015,52(4):999-1006
Thiazole and bisthiazole derivatives represent a prevalent scaffold in the antimicrobial drug discovery. Therefore, we have decided to synthesize some new series of 4,5′‐bisthiazoles. A total of 17 compounds were synthesized, their structural elucidation being based on elemental analysis (C,H,N,S) and spectroscopic data (MS and 1H NMR). Their in vitro antimicrobial activities were assessed against several Gram‐positive and Gram‐negative bacteria strains and also against one fungal strain (Candida albicans) using the difusimetric method. Some of the compounds showed modest to good antibacterial activity against Gram‐negative Escherichia coli and Salmonella typhimurium and Gram‐positive Staphylococcus aureus and Bacillus cereus bacterial strains. All of the synthesized compounds showed moderate to very good antifungal activity against C. albicans. 相似文献
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Synthesis and Antimicrobial Activity of Some New N‐substituted‐5‐arylidene‐thiazolidine‐2,4‐diones 下载免费PDF全文
Anca Stana Brînduşa Tiperciuc Mihaela Duma Laurian Vlase Ovidiu Crişan Adrian Pîrnău Ovidiu Oniga 《Journal of heterocyclic chemistry》2014,51(2):411-417
A total of 17 new N‐substituted derivatives ( 2b , 2c , 2d , 2e , 2f , 2g , 2h , 2i , 2j , 2k and 3b , 3c , 3d , 3e , 3f , 3g , 3h ) of 5‐((2‐phenylthiazol‐4‐yl)methylene) thiazolidine‐2,4‐dione ( 2a ) and 5‐(2,6‐dichloro‐ benzylidene)thiazolidine‐2,4‐dione ( 3a ) were synthesized. The structural elucidation of the newly synthesized compounds was based on elemental analysis and spectroscopic data (MS, 1H NMR, 13C NMR), and their antimicrobial activities were assessed in vitro against several strains of Gram‐positive and Gram‐negative bacteria and one fungal strain (Candida albicans) as growth inhibition diameter. Some of them showed modest to good antibacterial activity against Gram‐negative Escherichia coli and Salmonella typhimurium and Gram‐positive Staphylococcus aureus, Bacillus cereus, and Enterococcus fecalis bacterial strains, whereas almost all the compounds were inactive against Listeria monocytogenes. All of the synthesized compounds showed moderate to very good activity against C. albicans. 相似文献
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Meda RN Vlase L Lamien-Meda A Lamien CE Muntean D Tiperciuc B Oniga I Nacoulma OG 《Natural product research》2011,25(2):93-99
Balanites aegyptiaca is a tropical plant which is widely used for medicinal purposes in several African countries, including Burkina Faso. Despite its widespread use, little is known about its phenolic content. This study sought to carry out a screening of the polyphenols from the leaves and galls of B. aegyptiaca. A high-performance liquid chromatography-mass spectrometry method was used to investigate the phenolic content in the parts of the plant studied here. The phenolic acid profile showed the presence of gentisic, p-coumaric, caffeic, ferulic and sinapic acids in the crude and hydrolysed extracts. The flavonoids pattern showed hyperoside, isoquercitrin, rutoside and quercitrin in the crude extract of leaves. Myricetol, quercetol and kaempferol were found after acid hydrolysis of the leaves extract. Ferulic acid, isoquercitrin, rutoside and quercitrin were identified as major phenolic compounds in this study. 相似文献
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Daniela Hanganu Mihaela Niculae Irina Ielciu Neli-Kinga Olah Melania Munteanu Ramona Burtescu Rzvan tefan Loredana Olar Emoke Pall Sanda Andrei Dan C. Vodnar Daniela Benedec Ilioara Oniga 《Molecules (Basel, Switzerland)》2021,26(11)
Syringa vulgaris L. (common lilac) is one of the most popular ornamental species, but also a promising not comprehensively studied source of bioactive compounds with important therapeutic potential. Our study was designed to characterize the chemical composition and to assess the antioxidant and cytotoxic properties of ethanolic extracts obtained from S. vulgaris L. flowers, leaves, bark, and fruit. The chemical profile of the ethanolic extracts was investigated using chromatographic (HPLC-DAD-ESI+, GC-MS) and spectral (UV-Vis, FT-IR) methods, while the protective effect against free radicals was evaluated in vitro by different chemical assays (DPPH, FRAP, CUPRAC). The cytotoxic activity was tested on two tumoral cell lines, HeLa, B16F10, using the MTT assay. Significant amounts of free or glycosylated chemical components belonging to various therapeutically important structural classes, such as phenyl-propanoids (syringin, acteoside, echinacoside), flavonoids (quercetin, kaempferol derivatives) and secoiridoids (secologanoside, oleuropein, 10-hydroxy oleuropein, demethyloleuropein, syringalactone A, nuzhenide, lingstroside) were obtained for the flowers, leaves and bark extracts, respectively. Furthermore, MTT tests pointed out a significant cytotoxic potential expressed in a non-dose-dependent manner toward the tumoral lines. The performed methods underlined that S. vulgaris extracts, in particular belonging to flowers and leaves, represent valuable sources of compounds with antioxidant and antitumoral potential. 相似文献
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Dagobert Tazoo Ovidiu Oniga D. Scott Bohle Zhijie Chua Etienne Dongo 《Journal of heterocyclic chemistry》2012,49(4):768-773
2‐Aryl‐4‐methyl‐5‐acetylthiazoles, which were prepared from arylthioamides and chloroacetylacetone, were treated with 6‐substituted‐3‐formylchromones or arylaldehydes to give a series of eighteen new thiazolylchalcones in good yields. The structures of all the synthesized compounds were characterized by 1H NMR, 13C NMR, and ES‐MS spectrometry. Additionally, the crystal structures of two of these chalcones were determined by X‐ray diffraction analysis. 相似文献
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Summary The synthesis of some 4-formyl-2-aryl-2,4-bisthiazoles by the methods ofSommelet andKröhnke is described. TheSommelet reaction attacks position 4 of the thiazolic ring.
Heterocyclen, 71. Mitt. Anwendung derSommelet- undKröhnke-Reaktionen auf 2,4-Bisthiazole
Zusammenfassung Die Synthese einiger 4-Formyl-2-aryl-2,4-bisthiazole wird beschrieben. DieSommelet-Reaktion greift die Position 4 des Thiazolrings an.相似文献
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Irina Ielciu Bogdan Sevastre Neli-Kinga Olah Andreea Turdean Elisabeta Chie Raluca Marica Ilioara Oniga Alina Uiflean Alexandra C. Sevastre-Berghian Mihaela Niculae Daniela Benedec Daniela Hanganu 《Molecules (Basel, Switzerland)》2021,26(6)
Rosmarinus officinalis L. is a widely known species for its medicinal uses, that is also used as raw material for the food and cosmetic industry. The aim of the present study was to offer a novel perspective on the medicinal product originating from this species and to test its hepatoprotective activity. The tested sample consisted in a tincture obtained from the fresh young shoots. Compounds that are evaluated for this activity are polyphenols and terpenoids, that are identified and quantified by HPLC–UV–MS and GC–MS. Antioxidant activity was assessed in vitro, using the DPPH, FRAP and SO assays. Hepatoprotective activity was tested in rats with experimentally-induced hepatotoxicity. In the chemical composition of the tincture, phenolic diterpenes (carnosic acid, carnosol, rosmanol, rosmadial) and rosmarinic acid were found to be the majority compounds, alongside with 1,8-cineole, camphene, linalool, borneol and terpineol among monoterpenes. In vitro, the tested tincture proved significant antioxidant capacity. Results of the in vivo experiment showed that hepatoprotective activity is based on an antioxidant mechanism. In this way, the present study offers a novel perspective on the medicinal uses of the species, proving significant amounts of polyphenols and terpenes in the composition of the fresh young shoots tincture, that has proved hepatoprotective activity through an antioxidant mechanism. 相似文献
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