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DNA-hydrolyzing activity of IgG autoantibodies from sera of patients with various types of lymphoproliferative diseases was investigated. The association of DNA-hydrolyzing activity with the antibody (Ab) fraction has been proved by newly developed affinity-capture assay. Study of abzyme incidence in blood tumors and systemic lupus erythematosis (SLE) revealed linkage of anti-DNA Ab catalysts to mature B-cell tumors, and increased probability of DNA-abzymes formation on the background of autoimmune manifestations. These data suggest possible similarity between mechanisms of abzyme formation in SLE and B-cell lymphomas. A new mechanism of formation of DNA-specific catalytic Abs has been proposed based on the increased crossreactivity of polyclonal DNA-abzymes to DNA-depleted nuclear matrix proteins. The possibility of the abzyme production as Ab to the energetically destabilized ground state of the antigen has been discussed. Preliminary results were obtained that indicate the complement-independent cytotoxicity of anti-DNA autoantibodies isolated from blood of patients with SLE and chronic lymphocytic leukemia.  相似文献   
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ABSTRACT: BACKGROUND: The peri-adolescent period is a crucial developmental moment of transition from childhood to emergent adulthood. The present report analyses the differences in Power Spectrum (PS) of the Electroencephalogram (EEG) between late childhood (24 children between 8 and 13 years old) and young adulthood (24 young adults between 18 and 23 years old). RESULTS: The narrow band analysis of the Electroencephalogram was computed in the frequency range of 0--20 Hz. The analysis of mean and variance suggested that six frequency ranges presented a different rate of maturation at these ages, namely: low delta, delta-theta, low alpha, high alpha, low beta and high beta. For most of these bands the maturation seems to occur later in anterior sites than posterior sites. Correlational analysis showed a lower pattern of correlation between different frequencies in children than in young adults, suggesting a certain asynchrony in the maturation of different rhythms. The topographical analysis revealed similar topographies of the different rhythms in children and young adults. Principal Component Analysis (PCA) demonstrated the same internal structure for the Electroencephalogram of both age groups. Principal Component Analysis allowed to separate four subcomponents in the alpha range. All these subcomponents peaked at a lower frequency in children than in young adults. CONCLUSIONS: The present approaches complement and solve some of the incertitudes when the classical brain broad rhythm analysis is applied. Children have a higher absolute power than young adults for frequency ranges between 0-20 Hz, the correlation of Power Spectrum (PS) with age and the variance age comparison showed that there are six ranges of frequencies that can distinguish the level of EEG maturation in children and adults. The establishment of maturational order of different frequencies and its possible maturational interdependence would require a complete series including all the different ages.  相似文献   
3.
The fragmentations of [AA + M]+ complexes, where AA = Phe, Tyr, Trp, or His, and M is a monovalent metal (Li, Na, or Ag), have been exhaustively studied through collision-induced dissociation (CID) and through deuterium labeling. Dissociations of the Li- and Ag-containing complexes gave a large number of fragment ions; by contrast, the sodium/amino acid complexes have lower binding energies, and dissociation resulted in much simpler spectra, with loss of the entire ligand dominating. Unambiguous assignments of these fragment ions were made and formation mechanisms are proposed. Of particular interest are fragmentations in which the charge was retained on the organic fragment and the metal was lost, either as a metal hydride (AgH) or hydroxide (LiOH) or as the silver atom (Ag?).
Caption for Graphical Abstract
CID products of Li+, Na+, and Ag+ complexes of Phe, Tyr, Trp, and His are reported and mechanisms by which they are formed are proposed.  相似文献   
4.
A convenient synthesis of intermediate 4,5‐diamino‐3‐aryl‐1‐phenylpyrazoles 4a – 4c was reported. The different cyclization reactions were carried out with chalcone, 2‐mercaptoacetic acid and p‐anisialdehyde, ethyl chloroformate, glyoxal and thiourea to afford different N and S containing heterocycles. The reaction conditions were compared by conventional heating and microwave irradiation. The structures of the cyclization products were determined by analytical and spectroscopic data. All the synthesized compounds were screened for antibacterial activities in vitro.  相似文献   
5.
A variety of pyrimidine derivatives 2—4 and annulated pyrimidine derivatives 5—17 have been synthesized via a sequence of heterocyclization reaction of readily available 6-naphthyl-4-oxo-2-thioxo-1,2,3,4-tetrahydroprimi-  相似文献   
6.
Triphenylmethylphosphonium salts, [PPh3Me]aMXn (M=Cu2+, Co2+, Mn2+, Ni2+ Fe3+ Pb2+ and Hg2+; X=Cl or I; a=1 or 2 and n=3 or 4) prepared by reacting PPh3MeX with the metal dihalide in EtOH sol-utions, have been characterized by electronic, Raman, far i.r. and Mo¨ssbaur spectra and by their magnetic properties as well as by elemental analyses. The copper complexes [PPh3Me]2CuCl4 and [PPh3Me]2Cu3Cl8 were characterized by X-ray crystallography and the structures are described. Powder diffraction patterns have shown that the cobalt and manganese tetrachloride complexes are isomorphous. Investigation by d.s.c. measurements showed that the complexes exhibit structural phase transitions.  相似文献   
7.
本文讨论了用原子吸收和电感耦合等离子体发射光谱法(ICP-AES)测定经高压釜溶解的营养性埃及植物,如胡芦巴、甘草和莲座丛,并讨论了该法用于被消解植物样品中多元素日常分析的优点。这些样品具有较宽的元素含量范围,准确地测定这些营养性样品的主量和微量元素特别是有毒元素,对埃及人民的健康非常重要。ICP-AES法同时也用于被视为尼罗河净化剂的水生风信子的分析。分析结果表明,该植物能够有效地吸收有毒元素。被研究的植物经高压釜溶解,其溶液经原子吸收和ICP-AES法测定。作者对分析结果进行了对比,并阐明了二者之间的关系。  相似文献   
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