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Huricha Baigude Kaname Katsuraya Kohsaku Okuyama Kenichi Hatanaka Emi Ikeda Naokazu Shibata Toshiyuki Uryu 《Journal of polymer science. Part A, Polymer chemistry》2004,42(6):1400-1414
A novel sugar‐containing poly(ornithine) dendrimer is synthesized for possible antigen delivery and related applications. The dendrimer contains an ornithine dendron as interior scaffolding and oligosaccharides on the periphery, which provide an attachment site for a peptide antigen. Maltose or lactose is bound to both hemispherical and spherical poly(ornithine) dendrimer generation 3 (G3) by reductive amination between its reducing end and the peripheral amino group of the dendrimer using a borane‐pyridine complex in a buffer solution at 50 °C. The degree of substitution of sugar is changed by varying the molar ratio of sugar to dendrimer. When the surface of spherical poly(ornithine) dendrimer G3 is modified by binding β‐alanine to the 16 amino groups, highly substituted maltose‐ or lactose‐β‐alanine‐poly(ornithine) dendrimer G3 is obtained in high yield after 7 days of reaction. The structures of these sugar‐containing dendrimers are characterized by NMR and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry analyses. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 1400–1414, 2004 相似文献
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Huricha Baigude Kaname Katsuraya Kousaku Okuyama Yoshihide Yachi Shoma Sato Toshiyuki Uryu 《Journal of polymer science. Part A, Polymer chemistry》2002,40(21):3622-3633
A reactive three‐layered dendrimer containing carboxyl groups was synthesized by the coupling of dicarboxylic acid and a highly reactive, two‐layered glycopeptide dendrimer. Lactose, maltose, or maltotriose was reacted with the poly(lysine) dendrimer in its third and fourth generations by reductive amination and afforded two‐layered glycolysine dendrimers. The reaction was conducted in a borate buffer (pH 9.0). 1H NMR, 13C NMR, and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry analyses were applied for the determination of the structures of the products. When an excess amount of the oligosaccharide and a long reaction time were used, the degree of substitution increased to 1.5–2.0 against an amino group. For the preparation of highly reactive, multilayered dendrimers for an antigen carrier, C6 hydroxy groups of the oligosaccharides were selectively esterified by adipic acid and suberic acid to give 6‐O‐adipoyl oligosaccharide–poly(lysine) dendrimers and 6‐O‐suberoyl oligosaccharide–poly(lysine) dendrimers. The reactivity of these multilayered dendrimers was examined by a model reaction with phenylalanine ethyl ester. The dendrimer showed high reactivity, providing phenylalanine ethyl ester–dicarboxylate oligosaccharide–poly(lysine) dendrimers with a considerably high proportion of phenylalanine residues. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 3622–3633, 2002 相似文献
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Erdenebaatar Sarnaizul Gereltu Borjihan Huricha Baigude Aona Menghe Narisu Zhaorigetu 《Biomedical chromatography : BMC》2013,27(7):821-824
Only one kind of synthesized alkaloid, piperlonguminine, was used to understand the interference of the other alkaloids in pharmacokinetic study using HPLC/UV in rat plasma after oral administration. Compared with the previous report, it was clarified that mixed alkaloids such as piperine and the other extract from Piper longum Linn did not interfere with the results. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
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Guo-Guang Liu Gereltu Borjihan Huricha Baigude Hedeki Nakashima Toshiyuki Uryu 《先进技术聚合物》2003,14(7):471-476
Sulfated astragalus polysaccharide (sulfated astragalan, SA) was prepared by chemical modification of astragalus polysaccharide abstracted from an astragalus menbranceus used as a Mongolia herbal medicine. Anti-HIV activity of SA was assayed in vitro and the results indicated that the SA showing high anti-HIV activity and lower cytotoxity. Sulfation of astragalan was carried out by using sulfur trioxide-pyridine complex in a mixture of dimethylsulfoxide (DMSO) to give sulfated astragalan with degree of substitution (DS) of 1.14–1.20 and a number average molecular weight (Mn) of 1.27–1.46 × 104. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
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Huricha Baigude Kaname Katsuraya Shinichi Tokunaga Naohiko Fujiwara Masaya Satoyama Tomohiro Magome Kohsaku Okuyama Gereltu Borjihan Toshiyuki Uryu 《Journal of polymer science. Part A, Polymer chemistry》2005,43(11):2195-2206
A novel cellobiose–polylysine dendrimer with reducing sugar terminals was synthesized in which the reactive reducing end of a disaccharide cellobiose was directing outward. Hexa‐O‐benzyl‐4′‐(1‐carboxyethyl)‐cellobioside (HBCEC) was synthesized through the reaction of a 4′‐hydroxyl group of benzyl hexa‐O‐benzyl‐cellobioside with methyl 2‐chloropropionate, followed by the removal of the methyl ester group. HBCEC was reacted with polylysine dendrimer generation 3 (G3) to produce benzylated cellobiose–polylysine dendrimer G3. After debenzylation, a cellobiose–polylysine dendrimer G3 was obtained in which the reducing end of the cellobiose was the terminal group of the dendrimer. For the preparation of a dendrimer‐type acquired immunodeficiency syndrome vaccine, the cellobiose–polylysine dendrimer was reacted with a tripeptide (glycyl–prolyl–leucine) and a cyclic oligopeptide from the human immunodeficiency virus by reductive amination; this produced a tripeptide‐bound cellobiose–polylysine dendrimer and an insoluble compound, respectively. The structure analysis was carried out with NMR and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 2195–2206, 2005 相似文献
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