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排序方式: 共有1394条查询结果,搜索用时 312 毫秒
1.
Application of the 19F NMR technique to observe binding of the general anesthetic halothane to human serum albumin. 总被引:1,自引:0,他引:1
Kazuaki Shikii Satoshi Sakurai Hiroaki Utsumi Hiroko Seki Mitsuru Tashiro 《Analytical sciences》2004,20(10):1475-1477
19F NMR techniques were employed to characterize the binding property of the widely used general anesthetic halothane with human serum albumin (HSA). It was found that 19F(1H) NOE and 2D 1H-19F HOESY experiments detected intermolecular NOEs between halothane 19F and HSA protons. Measurements of the diffusion coefficients for halothane were also carried out by 1H and 19F NMR, indicating the interaction of halothane with HSA. The present results indicate that these techniques are very suitable to identify a fluorine-containing ligand binding with a protein receptor in the drug-discovery process. 相似文献
2.
3.
Ryoko Chiba Ayako Ogasawara Teppei Kubo Hiroyuki Yamazaki Masuo Umino Yoichi Ishizuka 《Analytical sciences》2003,19(5):785-789
A column-switching high-performance liquid chromatographic method with fluorescence detection was developed for the simultaneous determination of four benzamide-type anti-psychotic drugs: sulpiride, tiapride, sultopride and metoclopramide in human serum. In this method, a TSKgel Super-ODS column was used as an analytical column, and a TSKgel G 2000SW was prepared as a pretreatment column. Under the optimized analytical conditions, four benzamide-type anti-psychotic drugs were eluted within 18 min. The detection limits (S/N = 3) for sulpiride, tiapride, sultopride and metoclopramide are 1 ng/ml, 4 ng/ml, 2 ng/ml and 0.5 ng/ml, respectively. Finally, the method was applied to the determination of sulpiride in human serum samples obtained after a single oral dose of sulpiride. 相似文献
4.
Isao Tanikawa Nobuo Hirakawa Hiroko Hosono Hiroshi Nakamura 《Analytical sciences》2007,23(11):1267-1274
Hydro-membrane gas chromatography (HMGC) is achieved by the annular condensation of water in a capillary column at less than 70 degrees C. The annular membrane of water is formed as a result of the wettability of the stationary phase, which is induced at a water contact angle ranging from 75 degrees to 79 degrees, as derived from a solubility parameter (delta) range of 15.7 +/- 0.3 MPa(1/2) of the coated resin. The range of the liquid to gas volume ratio (beta) required to support the annular membrane should be kept between 0.00005 and 0.0003. In the case of a 0.25-mm i.d. column, the ratio can be set by the combination of a 0.1 to 0.2 microl min(-1) water supply rate and helium gas flow rate. Separation by HMGC develops not only a gas-solid partition but also a focusing effect on the water membrane. One feature of HMGC is that it gives a non-adsorption chromatogram based on the blocking effect of pre-adsorbed water; furthermore, despite the presence of a relatively large quantity of water, the electron impact ionization efficiency is kept the same as in the usual GC/MS condition. The detection limit with the injection of 1 microl of aquatic solution was estimated to be less than 0.1 ppb of low-molecular-weight fatty acids with s/n = 5 on a mass chromatogram at m/z 45. The HMGC/EI-MS system can be applied to the trace analysis of C1 to C3 volatile acids, volatile inorganic acids, and halogenated organic acids in water. 相似文献
5.
Masahiro Kubo 《Journal of Evolution Equations》2007,7(4):701-717
We study an abstract second order nonlinear evolution equation in a real Hilbert space. We consider time-dependent convex
functions and their subdifferentials operating on the first derivative of the unknown function. Introducing appropriate assumptions
on the convex functions and other data, we prove the existence and uniqueness of a strong solution, and give some applications
of the abstract theorem to hyperbolic variational inequalities with time-dependent constraints.
相似文献
6.
M. Wada Y. Ishida T. Nakamura Y. Kanai T. M. Kojima A. Takamine Y. Yamazaki K. Okada A. Yoshida T. Kubo I. Katayama S. Ohtani V. Varentsov H. Wollnik V. Lioubimov H. A. Schuessler 《Hyperfine Interactions》2006,173(1-3):153-163
A next-generation slow radioactive nuclear ion beam facility (SLOWRI) which provides slow, high-purity and small emittance ion beams of all elements is being build as one of the principal facilities at the RIKEN RI-beam factory (RIBF). High energy radioactive ion beams from the projectile fragment separator BigRIPS are thermalized in a large gas catcher cell. The thermalized ions in the gas cell are guided and extracted to a vacuum environment by a combination of dc electric fields and inhomogeneous rf fields (rf carpet ion guide). From there the slow ion beam is delivered via a mass separator and a switchyard to various devices: such as an ion trap, a collinear fast beam apparatus, and a multi-reflection time of flight mass spectrometer. In the R&D works at the present RIKEN facility, an overall efficiency of 5% for a 100A MeV 8Li ion beam from the present projectile fragment separator RIPS was achieved and the dependence of the efficiency on the ion beam intensity was investigated. Recently our first spectroscopy experiment at the prototype SLOWI was performed on Be isotopes. Energetic ions of 10Be and 7Be from the RIPS were trapped and laser cooled in a linear rf trap and the specific mass shifts of these isotopes were measured for the first time. 相似文献
7.
8.
Simple modules over the Leibniz pairs are studied. Simple Poisson modules over Poisson algebras of the semisimple associative algebra structure are determined and they are nothing but simple bimodules over simple associative algebras with standard noncommutative Poisson algebra structure. 相似文献
9.
Masahiro Kubo 《Journal of Mathematical Analysis and Applications》2005,307(1):232-244
We study Neumann problem for a class of nonlinear degenerate parabolic PDE. A typical nonlinearity we have in mind is, for instance, β(u)=−1/u(u>0). We establish a necessary and sufficient condition on given data for existence of solution. 相似文献
10.
M. K. Kubo Y. Sakai T. Tominaga K. Nishiyama K. Nagamine 《Journal of Radioanalytical and Nuclear Chemistry》1989,136(1):61-66
Diamagnetic muon yields /PD/ in various metal acetylacetonates were measured at room temperature by the muon spin rotation technique. We have found a clear difference in PD between complexes of typical elements and those of transition elements. We suggest that partially filled inner orbitals play some important role in determining the diamagnetic yield in these complexes. 相似文献