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Anders Helander Naama Kenan Olof Beck 《Rapid communications in mass spectrometry : RCM》2010,24(12):1737-1743
Official guidelines originating from a European Union directive regulate requirements for analytical methods used to identify chemical compounds in biological matrices. This study compared different liquid chromatography/electropray ionization mass spectrometry (LC/ESI‐MS) and tandem mass spectrometry (LC/ESI‐MS/MS) procedures for accurate determination of the conjugated ethanol metabolite and alcohol biomarker ethyl glucuronide (EtG) in urine, and the value of combined EtG and ethyl sulfate (EtS) measurement. Analysis was carried out on 482 urines following solid‐phase extraction (SPE) sample cleanup or using direct injection of a diluted sample. SPE combined with LC/MS/MS was demonstrated to be the most selective and sensitive method and was chosen as reference method. The EtG results by different methods showed good correlation (r = 0.96–0.98). When comparing five reporting limits for EtG in the range 0.10–1.00 mg/L, the overall agreement with the reference method (frequency of true positives plus true negatives) was 82–97% for direct‐injection LC/MS/MS, 90–97% for SPE‐LC/MS, 86–98% for direct‐injection LC/MS, and 86–98% for direct‐injection LC/MS analysis of EtG and EtS. Most deviations were attributable to uncertainty in quantitation, when the value was close to a cutoff but the respective results were slightly above and below, or vice versa, the critical limit. However, for direct‐injection LC/MS/MS, despite earning 4 identification points, equally many negative results were due to a product ion ratio outside the ±20% deviation accepted by the guidelines. These results indicate that the likelihood of different analytical methods to provide reliable analytical results depends on the reporting limit applied. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Wirtanen G Salo S Helander IM Mattila-Sandholm T 《Colloids and surfaces. B, Biointerfaces》2001,20(1):37-50
Biofilms of the Gram-negative bacteria Pseudomonas aeruginosa and Pseudomonas fragi were grown on stainless steel surfaces (AISI 304, 2B) for 4 days in slime broth. These biofilms were treated with four commercial disinfectants. The disinfectants were alcohol-based, tenside-based, peroxide-based and chlorine-based products, covering most disinfectant types used in the food industry. The effects of the disinfectants on the bacterial cells were first investigated in suspension using the permeabilisation test, which is based on fluorescence assessment of hydrophobic 1-N-phenyl-naphtylamine (NPN). The surfaces covered with disinfectant-treated biofilms were investigated using conventional cultivation, impedimetry and epifluorescence microscopy in combination with image analysis of preparations stained with the DNA-stain acridine orange and with the metabolic indicator system CTC-DAPI. The results showed that the tenside-based and peroxide-based disinfectants permeabilised the cells in suspension. The overall biofilm results showed that of the agents tested, the peroxide-based and chlorine-based disinfectants acted most effectively on cells in biofilms. 相似文献
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P. Helander S. J. Fielding R. H. Cohen D. D. Ryutov 《Czechoslovak Journal of Physics》2000,50(12):1421-1430
It has been suggested that by electrically biasing the divertor tiles in a tokamak, one could create a toroidally-asymmetric
potential structure in the scrape-off layer (SOL) plasma. The resultingE×B convective motion should increase the plasma transport in the SOL and thereby reduce the heat load on the divertor plates.
This paper describes plans for such experiments on COMPASS-D and preliminary theoretical modelling. The COMPASS-D divertor
target consists of 24 graphite tiled toroidal segments. The inner and outer strike point tiles on all these segments will
be insulated from each other, and cabling will be installed to allow for biasing of individual tiles in any combination. Theoretical
analysis suggests that the electrostatic potential perturbations caused by the biasing will be confined to the divertor region
below the X-point, and that substantial SOL broadening can be achieved by applying modest voltages. Aside from active control
of SOL transport, it is hoped that the biasing will be useful to probe other divertor and SOL physics issues.
Presented at the Workshop on the Role of Electric Fields in Plasma Confinement and Exhaust, Budapest, 18–19 June, 2000.
This work was jointly funded by the UK Department of Trade and Industry and Euratom, and was supported by US DoE under contract
W-7405-ENG-48 at LLNL. 相似文献
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It is shown that electron-positron pair production is expected to occur in post-disruption plasmas in large tokamaks, including JET and JT-60U, where up to about 10(14) positrons may be created in collisions between multi-MeV runaway electrons and thermal particles. If the loop voltage is large enough, they are accelerated and form a beam of long-lived runaway positrons in the direction opposite to that of the electrons; if the loop voltage is smaller, the positrons have a lifetime of a few hundred ms, in which they are slowed down to energies comparable to that of the cool ( less, similar 10 eV) background plasma before being annihilated. 相似文献
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Xanthopoulos P Mischchenko A Helander P Sugama H Watanabe TH 《Physical review letters》2011,107(24):245002
The relation between magnetic geometry and the level of ion-temperature-gradient (ITG) driven turbulence in stellarators is explored through gyrokinetic theory and direct linear and nonlinear simulations. It is found that the ITG radial heat flux is sensitive to details of the magnetic configuration that can be understood in terms of the linear behavior of zonal flows. The results throw light on the question of how the optimization of neoclassical confinement is related to the reduction of turbulence. 相似文献
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High efficiency orange OLEDs have been achieved using a trifunctional Pt(II) complex that contains an electron-transporting triarylborane and a hole-transporting triarylamine. 相似文献
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ZM Hudson C Sun MG Helander YL Chang ZH Lu S Wang 《Journal of the American Chemical Society》2012,134(34):13930-13933
The first examples of BMes(2)-functionalized NHC chelate ligands have been achieved. Their Pt(II) acetylacetonate complexes have been synthesized and fully characterized. These NHC-chelate Pt(II) compounds display highly efficient blue or blue-green phosphorescence in solution (Φ = 0.41-0.87) and the solid state (Φ = 0.86-0.90). Highly efficient electroluminescent devices based on these new Pt(II) compounds have also been fabricated. 相似文献