Design and synthesis of novel type somatostatin analogs with antiproliferative activities on A431 tumor cells

It was reported that the somatostatin analog TT-232, d-Phe-c(Cys-Tyr-d-Trp-Lys-Cys)-Thr-NH₂, exhibited a highly potent antitumor activity in vitro and in vivo. Using pyrazinone analogs and aliphatic amino acids instead of the disulfide bond, we prepared novel type somatostatin analogs including the sequence essential for antitumor activities, Tyr-d-Trp-Lys. These analogs exhibited antiproliferative effect on A431 tumor cells.     

Monophosphorylation of ethylenediamine with systems generating low-coordination phosphoryl species

Phenyldioxophosphorane was generated by thermal fragmentation of N-(1-adamantyl)phenylphosphonamidic acid in ethylenediamine to give a 61% yield of N-(2-aminoethyl)phenylphosphonamidic acid. The zwitterionic structure repressed reaction of the other amino group. Neopentyl metaphosphate and ethyl metaphosphate were generated in the presence of ethylenediamine by heating appropriate derivatives of the 2,3-oxaphosphabicyclo[2.2.2]octene system in toluene. Again, the metaphosphate phosphorylated only one amino group to give O-alkyl N-(2-amino-ethyl)phosphoramidic acids, in zwitterionic form. © 1996 John Wiley & Sons, Inc.     

Distribution of activity concentration and dose rates in selected coastal areas on western and eastern Black Sea

Radioactivity measurements were performed, at the east (Georgia) and west (Romania) part of the Black Sea, for natural radionuclides and ¹³⁷Cs in collected water and sediment samples using lab-based and in situ gamma-ray spectrometry. The activity concentrations of ¹³⁷Cs at Georgian area in the sediment and seawater ranged between 20 to 50 Bq kg⁻¹ and 8 to 25 Bq m⁻³, respectively while at the Romanian area the activity concentration ranged from 10 to 30 Bq kg⁻¹ and 3 to 15 Bq m⁻³, respectively. The activity concentration values of ⁷Be at the Georgian area reached values up to (30 ± 4) Bq kg⁻¹. The induced dose rates to marine organisms in both areas estimated by the ERICA assessment tool were much lower than the screening value of 10 μGy h⁻¹.