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1.
H. G. Linde R. T. Gleason 《Journal of polymer science. Part A, Polymer chemistry》1984,22(11):3043-3062
Thermal degradation of the silica–aminopropylsilane–amic acid/imide interface was studied by modifying a high-surface-area, neutral silica gel with a number of substituted aminopropylsilanes (APS). These substrates were reacted further with phthalic anhydride or aromatic amic acid monomers and the thermal decomposition of the adsorbed/reacted materials was monitored by thermogravimetric analysis (TGA) and infrared (IR) spectroscopy. The 3-aminopropyltriethoxysilane/poly[N,N′-(p,p′-oxydiphenylene)pyromellitimide] interface was also evaluated by this method. Comparison clearly distinguishes the thermal decomposition of surface-bound APS from surface-bound alkylphthalimides, the adhesion product of alkylamines and aromatic amic acids. Alkylamine imidization with the elimination of aromatic amine (analogous to polymer scission) and the decomposition of the surface-bound imide are shown in the amic acid TGA profiles. This imidization and the accompanying aniline elimination begin at about 130°C, under nitrogen, to form the surface alkyl imide which slowly decomposes at 400°C. TGA analysis indicates that the surface-bound imide undergoes minimal degradation under nitrogen at 370 ± 10°C; temperatures above this threshold range produce changes in the APS–imide interface. 相似文献
2.
Ireland RE Gleason JL Gegnas LD Highsmith TK 《The Journal of organic chemistry》1996,61(20):6856-6872
A total synthesis of FK-506 (1) is presented. The synthesis features a highly convergent approach utilizing a block coupling strategy. Top and bottom half sections of the molecule are coupled by addition of a vinyl cuprate with a spiroenone. The alpha-allyl aldol functionality is revealed by a reductive opening of the spiroenone system. The labile alpha,beta-diketoamide hemiketal portion of the molecule is prepared by a late stage generation and oxidation of a masked enediol. Top and bottom half segments are themselves derived by coupling of smaller subunits, resulting in a very convergent route. 相似文献
3.
The total synthesis of a 3-thia- and a 3-aza-1-dethiacepham ( and ) are described. Neither compound possessed antibacterial activity . . An unsaturated analog, a 3-aza-1-dethiaceph-1-em exhibited weak antibacterial activity. 相似文献
4.
Dale F Shellhamer David C Gleason Andrew J Ryan Victor L Heasley 《Journal of fluorine chemistry》2003,123(2):171-176
Ionic and photochemical reaction of chlorine (Cl2), bromine (Br2) and iodine monochloride (ICl) to hexafluoro-1,3-butadiene (1) and 1,3-butadiene (2) were carried out under conditions that would provide product distributions under controlled ionic or free-radical conditions. Product distributions for ionic reaction of Cl2 and Br2 with 1 are similar and suggest a weakly-bridged halonium ion species. Theoretical calculations support weakly-bridged chloronium and bromonium ions for both dienes 1 and 2. There are more of the 1,4-dihalo-2-butene products from ionic halogenation of 1 than 2 which correlates with the greater charge density on carbon-4 of halonium ions from 1. Ionic and free-radical reactions of ICl with 1 give 8 and 2% of 3-chloro-4-iodohexafluoro-1-butene and 4-chloro-3-iodohexafluoro-1-butene, respectively. The minor cis-1,4-dihalo-2-butene products from 1 and 2 are reported when formed. 相似文献
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Density functional theory at the B3LYP/6-311++G(d,p) level is applied to calculate the (29)Si NMR chemical shifts of a variety of organosiloxane moieties including monomers or precursors for polymerization and representative segments of organosiloxane polymers or thin films. The calculated shifts of two linear dimethylsiloxane compounds, hexamethylcyclotrisiloxane (D3) and octamethylcyclotetrasiloxane (D4), compare well with their known values, having an average error of 3.4 ppm. The same method is applied to structures believed to occur in organosilicate glass thin films deposited using hot-filament chemical vapor deposition (HFCVD) from D3 and D4. The chemical shift at -15 ppm is identified as a cross-linking Si-Si bond between two strained D groups and has not previously been reported. Retention of the strained ringed structure in HFCVD films deposited from D3 is confirmed. The rings are bonded to the matrix through either Si-O or Si-Si bonds, with the latter only becoming prevalent when higher filament temperatures are employed. The strained ring structure is also observed in films deposited from a precursor with a larger unstrained ring structure, D4. These observations suggest that the known gas-phase conversion pathways of D4 to D3 and dimethylsilanone as well as the methyl abstraction reaction from D3 operate in the HFCVD reaction chemistry. 相似文献
8.
This paper describes a new technique--microscale steady-state kinetic analysis (microSKA)--that enables the rapid and parallel analysis of enzyme kinetics. Rather than physically defining a microscopic reactor through microfabrication, we show how the relative rates of reaction and transport in a macroscopic flow chamber, where the enzyme is immobilized on one wall of the chamber, results in the confinement of an enzyme-catalyzed reaction to a microscopic reactor volume adjacent to this wall. This volume has linear dimensions that are orders of magnitude smaller than the physical dimensions of the system (i.e., micrometer vs millimeter). Conversion within this volume is monitored at steady state as a function of position, rather than time. In this way, limitations due to reactor dead time and mixing are avoided. We use microSKA to determine kinetic parameters for the alkaline phosphatase-catalyzed de-phosphorylation of nonfluorescent methylumbelliferyl phosphate (MUP) to fluorescent 7-hydroxy-4-methylcoumarin (HMC) at two different values of pH. Kinetic parameters measured with microSKA are in good agreement with values obtained using conventional methods, if one takes into account effects of immobilization on enzyme activity. This technique provides a rapid and simple method for determining enzyme kinetics using small amounts of sample material and may be useful for applications in proteomics, drug discovery, biocatalyst development, and clinical diagnostics. 相似文献
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Kevin Gleason Francesco Carbone Alessandro Gomez 《Proceedings of the Combustion Institute》2021,38(2):2517-2524
We investigate the effect of pressure on both flame structure and soot formation in nitrogen diluted counterflow diffusion flames of ethylene in the 8–32atm pressure range. Capillary-probe gas sampling is performed to resolve spatially the profiles of gaseous species up to three-ring aromatics by GC/MS analysis and multi-color pyrometry is used to quantify the soot volume fraction and dispersion exponent. Self-similarity of flames is preserved by keeping constant mixture fraction and strain rate, so that profiles of concentrations and temperature, normalized with respect to their peak values, are unaffected by changes in pressure, once the axial coordinate is nondimensionalized with respect to the pressure-dependent diffusion length scale. When conditions are chosen so that the overall soot loading is approximately constant and compatible with the diagnostics, it is found that both the soot volume fraction and the profiles of key aromatics in the high-temperature nucleation region are virtually invariant. For it to happen, a twofold increase in pressure must be compensated by a ~100 K decrease in peak flame temperature and, therefore, in the temperature across the soot forming region. The implication is that from the perspective of the chemical kinetics of soot formation these two actions counterbalance each other. As pressure increases (and temperature decreases) the peak production rate of the high-temperature soot mechanism decreases and, further downstream, towards the particle stagnation plane, a low-temperature soot mechanism sets in, yielding an increase in soot H/C content. This mechanism is enhanced as the pressure is raised, causing a higher overall soot volume production rate in the 16atm flame and, especially, in the 32atm one. The role of C4/C2 species in the formation of C6H6 increases with increasing pressure and dominates over the recombination of propargyl radical at sufficiently high pressures. A comprehensive database is established for soot models at high pressures of relevance to applications. 相似文献