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The discovery of novel conditions for highly beta-stereoselective (>9 : 1) mannosylation of OH-2 of mannosides using a straightforward perbenzylthioglycoside donor has allowed ready assembly of beta-mannosyl oligosaccharides including the repeating trisaccharide motif of the O5 antigen of pathogen Klebsiella pneumoniae. 相似文献
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Patel MK Vijayakrishnan B Koeppe JR Chalker JM Doores KJ Davis BG 《Chemical communications (Cambridge, England)》2010,46(48):9119-9121
Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates. 相似文献
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Carbohydrates, either bound to proteins or in lipids, play essential roles as communication molecules in many intercellular and intracellular processes. In particular, carbohydrates are important mediators of cell-cell recognition events and have been implicated in related processes such as cell signaling regulation, cellular differentiation and immune response. This diverse utility has long suggested the power of carbohydrates in therapeutic approaches. This Concepts article highlights the recent potential uses of glycoconjugates as therapeutics, with particular reference to glycopeptides, glycoproteins, glycodendrimers, and glycoarrays. 相似文献
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The strategy of combined site directed mutagenesis and chemical modification with polar prosthetic groups was used to broaden substrate specificity of proteases resulting in the first successful formation of glycopeptides through the use of glucoamino acid acyl donors in yields of up to 90%. 相似文献
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Hotchkiss T Kramer HB Doores KJ Gamblin DP Oldham NJ Davis BG 《Chemical communications (Cambridge, England)》2005,(34):4264-4266
N-acetyl glucosamine binding protein amplifies the concentration of one member in a dynamic combinatorial glycopeptide library based on exchanging disulfides. 相似文献
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