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排序方式: 共有67条查询结果,搜索用时 125 毫秒
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Patrick A. Caruana 《Tetrahedron》2007,63(43):10646-10656
The scope and utility of the metal-catalyzed rearrangement of propargyl acetates first reported by Rautenstrauch were expanded. Treatment of a series of appropriate acetate substrates with Pd(II)- and Hg(II)-catalysts afforded synthetically useful fused 5,6-bicyclic-1,4-cyclopentadienyl acetates and 2-cyclopentenones. It was found that the substituents at the terminal alkynyl and alkenyl positions of the acetate substrate had a significant impact on the outcome of the reaction. 相似文献
4.
Georganopoulou DG Caruana DJ Strutwolf J Williams DE 《Faraday discussions》2000,(116):109-18; duscussion 171-90
In order to establish an experimental basis for exploring the reactivity of membrane-bound redox enzymes using electrochemistry at an organic/aqueous interface, the reactivity of glucose oxidase adsorbed at the dichloroethane/water interface has been studied. Turnover of glucose in the aqueous phase mediated by dimethyl ferricenium electrogenerated in the organic phase was measured by measuring the feedback current caused by recycling the mediator as the generator electrode approached close to the interface from the organic side. An unexpected self-exchange reaction of the ferrocene at the interface was suppressed by adsorption of a surfactant. The interfacial enzyme reaction could be distinguished from reaction within the bulk of the aqueous phase. Reaction within a protein-surfactant film formed at the interface is conjectured. 相似文献
5.
Mario Caruana Angelique Camilleri Maria Ylenia Farrugia Stephanie Ghio Michaela Jakubí
kov Ruben J. Cauchi Neville Vassallo 《Molecules (Basel, Switzerland)》2021,26(5)
The identification of compounds which protect the double-membrane of mitochondrial organelles from disruption by toxic confomers of amyloid proteins may offer a therapeutic strategy to combat human neurodegenerative diseases. Here, we exploited an extract from the marine brown seaweed Padina pavonica (PPE) as a vital source of natural bioactive compounds to protect mitochondrial membranes against insult by oligomeric aggregates of the amyloidogenic proteins amyloid-β (Aβ), α-synuclein (α-syn) and tau, which are currently considered to be major targets for drug discovery in Alzheimer’s disease (AD) and Parkinson’s disease (PD). We show that PPE manifested a significant inhibitory effect against swelling of isolated mitochondria exposed to the amyloid oligomers, and attenuated the release of cytochrome c from the mitochondria. Using cardiolipin-enriched synthetic lipid membranes, we also show that dye leakage from fluorophore-loaded vesicles and formation of channel-like pores in planar bilayer membranes are largely prevented by incubating the oligomeric aggregates with PPE. Lastly, we demonstrate that PPE curtails the ability of Aβ42 and α-syn monomers to self-assemble into larger β-aggregate structures, as well as potently disrupts their respective amyloid fibrils. In conclusion, the mito-protective and anti-aggregator biological activities of Padina pavonica extract may be of therapeutic value in neurodegenerative proteinopathies, such as AD and PD. 相似文献
6.
Catalytic Asymmetric Reactions of 4‐Substituted Indoles with Nitroethene: A Direct Entry to Ergot Alkaloid Structures 下载免费PDF全文
Simone Romanini Emilio Galletti Dr. Lorenzo Caruana Prof. Andrea Mazzanti Prof. Fahmi Himo Dr. Stefano Santoro Prof. Mariafrancesca Fochi Prof. Luca Bernardi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(49):17578-17582
A domino Friedel–Crafts/nitro‐Michael reaction between 4‐substituted indoles and nitroethene is presented. The reaction is catalyzed by BINOL‐derived phosphoric acid catalysts, and delivers the corresponding 3,4‐ring‐fused indoles with very good results in terms of yields and diastereo‐ and enantioselectivities. The tricyclic benzo[cd]indole products bear a nitro group at the right position to serve as precursors of ergot alkaloids, as demonstrated by the formal synthesis of 6,7‐secoagroclavine from one of the adducts. DFT calculations suggest that the outcome of the reaction stems from the preferential evolution of a key nitronic acid intermediate through a nucleophilic addition pathway, rather than to the expected “quenching” through protonation. 相似文献
7.
Direct insight into the mechanisms of flow and displacements within small-scale (cm) systems having permeability heterogeneities
that are not parallel to the flow direction (cross-bedding and fault zones) have been carried out. In our experiments, we
have used visual models with unconsolidated glass bead packs having carefully controlled permeability contrasts to observe
the processes with coloured fluids and streamlines. The displacements were followed visually and by video recording for later
analysis. The experiments show the significance that heterogeneities have on residual saturations and recovery, as well as
the displacement patterns themselves. During a waterflood, high permeability regions can be by-passed due to capillary pressure
differences, giving rise to high residual oil saturations in these regions. This study demonstrates the importance of incorporating
reservoir heterogeneity into core displacement analysis, but of course the nature of the heterogeneity has to be known. In
general, the effects created by the heterogeneities and their unknown boundaries hamper interpretation of flood experiments
in heterogeneous real sandstone cores. Our experiments, therefore, offer clear visual information to provide a firmer understanding
of the displacement processes during immiscible displacement, to present benchmark data for input to numerical simulators,
and to validate the simulator through a comparison with our experimental results for these difficult flow problems. 相似文献
8.
A new, vectorial approach to fast correlation attacks on binary memoryless combiners is proposed. Instead of individual input sequences or their linear combinations, the new attack is targeting subsets of input sequences as a whole thus exploiting the full correlation between the chosen subset and the output sequence. In particular, the set of all the input sequences can be chosen as the target. The attack is based on a novel iterative probabilistic algorithm which is also applicable to general memoryless combiners over finite fields or finite rings. To illustrate the effectiveness of the introduced approach, experimental results obtained for random balanced combining functions are presentedMost of this work was done while he was with Rome CryptoDesign Center, Gemplus, Italy 相似文献
9.
The motion of a holonomic scleronomic non-conservative mechanicalsystem with minimal dissipation is considered. As applicationsof the theory several problems are studied in detail. 相似文献
10.
We study a class of linear first and second order partial differential equations driven by weak geometric p-rough paths, and prove the existence of a unique solution for these equations. This solution depends continuously on the driving rough path. This allows a robust approach to stochastic partial differential equations. In particular, we may replace Brownian motion by more general Gaussian and Markovian noise. Support theorems and large deviation statements all become easy corollaries of the corresponding statements of the driving process. In the case of first order equations with Gaussian noise, we discuss the existence of a density with respect to the Lebesgue measure for the solution. 相似文献