Synthesis of optically active 6-substituted 2-(aminomethyl)chromans

Three novel, optically active, 6-substituted 2-(aminomethyl)chromans were synthesized from readily available chroman 2-carboxylic acid precursors. These chroman-containing primary amines are useful building blocks for the synthesis of chroman-derived pharmaceutical agents.     

Skein related links in 3-manifolds

This paper addresses two problems in the skein theory of homotopy spheres first posed by P. Traczyk. Solutions to both problems are obtained for a large class of manifolds and, since one of the basic techniques used requires the first homology group of the ambient manifold to be torsion free, the extent to which this hypothesis is actually necessary is further explored.     

Coherent single pion production by antineutrino charged current interactions and test of PCAC

The cross section for coherent production of a single π^? meson in charged current antineutrino interactions on neon nuclei has been measured in BEBC to be (175±25) 10^?40 cm²/neon nucleus, averaged over the energy spectrum of the antineutrino wide band beam at the CERN SPS; this corresponds to (0.9±0.1) % of the total charged current \(\bar v_\mu \) cross section. The distributions of kinematical variables are in agreement with theoretical predictions based on the PCAC hypothesis and the meson dominance model; in particular, theQ ² dependence is well described by a propagator containing a massm=(1.35±0.18) GeV. The absolute value of the cross section is also in agreement with the model. This analysis thus provides a test of the PCAC hypothesis in the antineutrino energy range 5–150 GeV.     

Diffractive production of ρ-mesons and of ρπ-systems by neutrinos and antineutrinos on protons

Evidence is presented for diffractive production of -mesons and of -systems invp and chargedcurrent interactions. In the (anti-)neutrino energy range 10 GeVE _v <60 gev=" the=" cross=" sections=" for=" diffractive="> and diffractive production are found to be (0.64±0.14 (stat.)±0.08 (syst.))% and (0.28±0.08 (stat.)±0.04 (syst.))% of the charged-current cross section. The diffractive signal is consistent with being entirely due to diffractivea ₁ production. However, the data cannot distinguish between diffractivea ₁ and diffractive nonresonant production. The experimental distributions ofW, Q ²,x _Bj andy _Bj for diffractive and events are consistent with model predictions.     

International Review of Science Solid State Chemistry,Inorganic Chemistry Series Two,Vol. 10 : Consultant Editor H.J. Emeleus FRS,Volume Editor L.E.J. Roberts,Butterworths, London, 1975, pp. 264, price £13.00

Complexes of nicotinic and isonicotinic acids and their deuterated analogues with pyridine, 4-Me pyridine and N Me imidazole have been examined by IR spectroscopy. Strong hydrogen bonding between an O atom of the acid and the N atom of the base with the H atom lying closer to the O atom, is present in all systems.     

Structures of reagent residues resulting from reactions of divinyl sulfone with cotton cellulose

Cotton cellulose in fabric form was crosslinked with divinyl sulfone by catalysis with solutions of sodium hydroxide of normalities ranging from 0.1 to 4.0. The molecular chains of cellulose were hydrolyzed with sulfuric acid to yield hydrolyzates from which simple substituted glucoses (i.e., those bonded to a single unit of DVS), the simple crosslinked glucoses (i.e., those joined together by a single unit of DVS), and complex structures (i.e., those substituted or crosslinked with more than one unit of DVS in the chain) were isolated and measured. The fractions of the reagent residues in the forms of the structures noted above were found to change substantially with the concentration of base employed to catalyze the reaction. The constitution of the reagent residues resulting from reaction in 0.1N base was remarkably simple: 82% of the DVS residues in the form of simple crosslinks and 18% in the form of simple substituents. Complex structures accounted for as much as 70% of the DVS residues under other conditions of reaction.     

Synthesis of some pyridylamino-1,4-disubstituted phthalazines

Two general procedures involving the condensation of phthalonitrile or 1,3-diiminoisoindoline with various aminopicolines, followed by ring expansion with hydrazine to the corresponding phthalazine are described. Syntheses are reported of 1, 4-di(3′-methyl-2′-pyridyl) aminophthalazine, 1,4-di(5′-methyl-2′-pyridyl)aminophthalazine, and 1,4-di(4′, 6′-dimethyl-2′-pyridyl)aminophthalazine.