Sensitive measurement of radiation trapping in cold-atom clouds by intensity correlation detection

We present experimental evidence that the intensity correlations of light scattered from a cold-atom cloud are sensitive to the presence of small amounts of radiation trapping in an atomic sample of density 6 x 10(8)/cm3, with an optical depth (for a resonant light beam) of 0.4. This density and optical depth are approximately an order of magnitude less than the density and on-resonance optical depth at which effects of multiple scattering in cold-atom clouds have been previously observed [Phys. Rev. Lett. 64, 408 (1990)].     

Rapid two-step synthesis of mitrin from heparosan: a replacement for heparin

We have engineered a two-step enzymatic synthesis of Mitrin which is a more potent and homogeneous anticoagulant than the current animal-derived heparin. This engineered heparin may have advantages of being free from animal-derived pathogens and may also have reduced side effects such as heparin induced thrombocytopenia. This approach can also be extended to tailor heparin-based drugs with improved therapeutic characteristics to treat other disorders or infections in which heparin-like molecules play a major role.     

Library synthesis using 5,6,7,8-tetrahydro-1,6-naphthyridines as scaffolds

The chemistry of 5,6,7,8-tetrahydro-1,6-naphthyridine scaffolds, synthesized by intramolecular cobalt-catalyzed [2 + 2 + 2] cyclizations, has been exploited for library synthesis. Urea, amide, and sulfonamide formations were used in the synthesis of a 101-membered library. Screening of the library for antituberculosis activity revealed three lead compounds.     

Crystallographic Characterization of Dipyridylamine Derivatives

Abstract  

Dipyridylamine has been coupled with phenyl groups to yield new organic ligands. During the course of one reaction a lithium salt of dipyridylamine was isolated as the product. These new compounds were characterized by single crystal X-ray diffraction, which reveals that π–π stacking interactions as well as hydrogen bonding permeate the isolated compounds in the solid state. BrPhDPA, compound 1, crystallizes in the monoclinic P2₁ space group with cell parameters a = 5.8291(1), b = 8.8504(2), c = 13.2341(3) ? and β = 91.928(1)°. 3-ThPh(DPA)₂, compound 4, crystallizes in the orthorhombic C2/c space group with cell parameters a = 14.8033(7), b = 11.4124(4), c = 16.11780(7) ? and β = 115.911(3)°. Finally the lithium salt, [Li(HDPA)(H₂O)₂](H₂DPA)(Cl)₂(H₂O), compound 5, crystallizes in the monoclinic Cmcm space group with cell parameters a = 14.043(3), b = 12.370(3) and c = 13.389(3) ?.     

Feedback Control Methodologies for Nonlinear Systems

A number of computational methods have been proposed in the literature to design and synthesize feedback controls when the plant is modeled by nonlinear dynamics. However, it is not immediately clear which is the best method for a given problem; this may depend on the nature of the nonlinearities, size of the system, whether the amount of control used or time needed for the method is a concern, and other factors. In this paper, a comprehensive comparison study of five methods for the synthesis of nonlinear control systems is carried out. The performance of the methods on several test problems are studied, and some recommendations are made as to which feedback control method is best to use under various conditions.     

Convergent synthesis of a complex oxime library using chemical domain shuffling

[reaction: see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.     

Synthesis of a library of complex macrodiolides employing cyclodimerization of hydroxy esters

The synthesis of complex macrodiolides involving microwave-accelerated transesterification of chiral, nonracemic, hydroxy esters is described. Methodology development studies indicate that both microwave power and reaction temperature play an important role in the efficiency of cyclodimerizations. Hydroxy ester monomer pairs were evaluated using an analytical rehearsal leading to the preparation of a 127-member library of highly diverse and stereochemically well-defined macrodiolides. Preliminary assays identified a novel macrodiolide antagonist of the kappa opioid receptor.