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Penjai Thongnuanjan Sirima Soodvilai Somsak Fongsupa Natechanok Thipboonchoo Napason Chabang Bamroong Munyoo Patoomratana Tuchinda Sunhapas Soodvilai 《Molecules (Basel, Switzerland)》2021,26(21)
Background: Panduratin A is a bioactive cyclohexanyl chalcone exhibiting several pharmacological activities, such as anti-inflammatory, anti-oxidative, and anti-cancer activities. Recently, the nephroprotective effect of panduratin A in cisplatin (CDDP) treatment was revealed. The present study examined the potential of certain compounds derived from panduratin A to protect against CDDP-induced nephrotoxicity. Methods: Three derivatives of panduratin A (DD-217, DD-218, and DD-219) were semi-synthesized from panduratin A. We investigated the effects and corresponding mechanisms of the derivatives of panduratin A for preventing nephrotoxicity of CDDP in both immortalized human renal proximal tubular cells (RPTEC/TERT1 cells) and mice. Results: Treating the cell with 10 µM panduratin A significantly reduced the viability of RPTEC/TERT1 cells compared to control (panduratin A: 72% ± 4.85%). Interestingly, DD-217, DD-218, and DD-219 at the same concentration did not significantly affect cell viability (92% ± 8.44%, 90% ± 7.50%, and 87 ± 5.2%, respectively). Among those derivatives, DD-218 exhibited the most protective effect against CDDP-induced renal proximal tubular cell apoptosis (control: 57% ± 1.23%; DD-218: 19% ± 10.14%; DD-219: 33% ± 14.06%). The cytoprotective effect of DD-218 was mediated via decreases in CDDP-induced mitochondria dysfunction, intracellular reactive oxygen species (ROS) generation, activation of ERK1/2, and cleaved-caspase 3 and 7. In addition, DD-218 attenuated CDDP-induced nephrotoxicity by a decrease in renal injury and improved in renal dysfunction in C57BL/6 mice. Importantly, DD-218 did not attenuate the anti-cancer efficacy of CDDP in non-small-cell lung cancer cells or colon cancer cells. Conclusions: This finding suggests that DD-218, a derivative of panduratin A, holds promise as an adjuvant therapy in patients receiving CDDP. 相似文献
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Pongchan Thinapong Orapin Rangsiman Patoomratana Tuchinda Bamroong Munyoo Manat Pohmakotr Vichai Reutrakul 《Acta Crystallographica. Section C, Structural Chemistry》2000,56(7):e309-e310
A new azaanthracene alkaloid, namely 9,10‐dimethoxy‐4‐methyl‐1,2‐dihydro‐1‐azaanthracen‐2‐one (kalasinamide), C16H15NO3, has been isolated from the stems of Polyalthia suberosa collected in the northeastern part of Thailand. Each of the aromatic rings in the molecule is planar within 0.021 (2) Å. Molecules are linked to form centrosymmetric dimers by N—H?O hydrogen bonds [N?O 2.941 (4) Å]. 相似文献
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