Synthesis and biological activity of <Emphasis Type="Italic">N</Emphasis>-(2-hydroxyethyl)cytisine derivatives

Derivatives of N-(2-hydroxyethyl)cytisine, N-(2-hydroxypropyl)-, N-(2-hydroxy-2-(1-adamantyl)ethyl)-, and N-(2-hydroxy-2-phenylethyl)cytisine, were synthesized by reduction of N-(2-oxopropyl)-, N-(2-oxo-2-(1-adamantyl)ethyl)-and N-(2-oxo-2-phenylethyl)cytisine with metal hydrides. The antiarrhythmic and analgesic activities of the prepared compounds were investigated. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 157–162, March–April, 2007.     

Synthesis and structure of <Emphasis Type="Italic">N</Emphasis>-(2-(1-adamantyl)-2-hydroxyethyl)cytisine diastereomers

Diastereomers of N-(2-(1-adamantyl)-2-hydroxyethyl)cytisine were synthesized by reduction of N-(2-(1-adamantyl)-2-oxoethyl)cytisine with NaBH₄. Their structures were established using x-ray structure analysis. __________ Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 244–247, May–June, 2007.     

Molecular structure of 3,7-dimethyl-9-thia-3,7-diazabicyclo[3.3.1]nonane-9,9-dioxide

By a single crystal X-ray diffraction study the molecular structure of 3,7-dimethyl-9-thia-3,7-diazabicyclo[3.3.1]nonane-9,9-dioxide having a chair-chair conformation with a diequatorial arrangement of methyl groups at nitrogen atoms is determined. Compound 1 C₈H₁₆N₂O₂S crystallizes in the space group Pnma with the following cell parameters: a = 11.0262(3) Å, b = 14.4490(3) Å, c = 6.1780(3) Å.     

Activation of the S-S bond in diphenyl disulfide by nickel complexes and its reaction with butadiene

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, p. 747, March, 1989.     

Synthesis and crystal structure of <Emphasis Type="Italic">N</Emphasis>(12)-(2-hydroxy-2-phenylethyl)cytisine

Diastereomers of N(12)-(2-hydroxy-2-phenylethyl)cytisine were synthesized by reduction of N(12)-(2-oxo-2-phenylethyl)cytisine by Yamamoto reagent. Their structures were solved using x-ray structure analysis.     

One-pot synthesis of 1,3-bis(cytisinyl)propan-2-ol

Russian Journal of Organic Chemistry -     

New approach to the synthesis of dihydrothiopyrans using cobalt complexes

Institute of Organic Chemistry, Bashkir Science Center, Urals Branch, Russian Academy of Sciences, 450054 Ufa, Bashkortostan, Russia. Translated fromIzvestiya Akademii Nauk, Seriya Khimicheskaya, No. 12, pp. 2813–2814, December, 1992.