Liquid chromatographic analysis of propranolol enantiomers in human blood using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate.

A method for the determination of the R-(+) and S-(-) enantiomers of propranolol in blood was developed. After extraction with heptane-isopentanol and derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate, excess reagent was removed using solid-phase extraction. The enantiomers were separated on an achiral, reversed-phase, radially compressed column, and detected by fluorescence with excitation and emission wavelengths of 260 and 340 nm, respectively. The limit of quantification was 0.5 ng/ml. This method was used for pharmacokinetic analysis of propranolol enantiomers after administration of immediate-release (80 mg) or sustained-release (160 mg) racemic propranolol.     

Antimatter and matter production in heavy ion collisions at CERN (The NEWMASS experiment NA52)

Besides the dedicated search for strangelets NA52 measures light (anti)particle and (anti)nuclei production over a wide range of rapidity. Compared to previous runs the statistics has been increased in the 1998 run by more than one order of magnitude for negatively charged objects at different spectrometer rigidities. Together with previous data taking at a rigidity of ?20 GeV/c we obtained $10^6 \bar p, 10^3 \bar d$ and two $\overline {^3 He} $ without centrality requirements. We measured nuclei and antinuclei (p, d, $\bar p,\bar d$ ) near midrapidity covering an impact parameter range of b ～ 2–12 fm. Our results strongly indicate that nuclei and antinuclei are mainly produced via the coalescence mechanism. However, the centrality dependence of the antibaryon to baryon ratios shows that antibaryons are diminished due to annihilation and breakup reactions in the hadron dense environment. The volume of the particle source extracted from coalescence models agrees with results from pion interferometry for an expanding source. The chemical and thermal freeze-out of nuclei and antinuclei appear to coincide with each other and with the thermal freeze-out of hadrons.     

Strangelet search and particle production studies in Pb+Pb collisions at 158 AGeV/c at CERN SPS

We searched for long-lived strange quark matter particles, so-calledstrangelets, and studied particle and antiparticle production in Pb+Pb collisions at 158 GeV/c per nucleon at zero degree production angle. We give upper limits for the production of strangelets covering a mass to charge ratio up to 120 GeV/c ² and lifetimest _lab>1.2 μs and plot invariant differential production cross sections as a function of rapidity for a variety of particles.     

A study of π andK production in proton-uranium and oxygen-uranium interactions at 22 GeV/A using decay muons

The like-sign dimuons copiously recorded in the NA 38 experiment both inp-U and O?U reactions at 200 GeV/nucleon are interpreted as resulting from decays of π andK mesons in comparable proportions. The ++/?? ratio is large (?1.7) and ascribed to theK ⁺ being more copiously produced than theK ^?. Both the average transverse momentum and the ++/?? ratio are comparable forp-U and O?U reactions, and both increase only slightly with the transverse energyE _T .     

Antiproton-proton elastic scattering at 6.2 GeV/c

Antiproton-proton elastic scattering data at 6.2 GeV/c in the range 0.3 (GeV/c)² ? ?t ? 10.0 (GeV/c)² is presented. The experiment, using spark chambers and proportional chambers, was performed at the CERN Proton Synchroton.The dip at about ?t = 0.5 and the structure at about ?t = 2.2 (GeV/c)² are equally strong at 6.2 GeV/c as they are at 5.0 GeV/c. The differential cross sections around 90° c.m. are not very different at 5.0 GeV/c and at 6.2 GeV/c, whereas in the backward region there is a decrease of the order of one magnitude.     

Spectroscopic studies of the ν2 mode of methyl iodide by Raman spectroscopy

Polarized Raman studies of the ν₂ mode in methyl iodide at 1 and 1600 bar have confirmed, through an independent route, the results previously found by isotopic-dilution studies. By using a cubic-close-packed approximation of the liquid state and a 1/r⁶ interaction potential for dipolar dephasing between molecules, the data may be reconciled. This result is interpreted to be strong evidence for the dominance of the intermolecular transition-dipole dephasing mechanism.     

Spectral Assignments and Structural Consequences Arising from the C-H Stretching Region of Norbornadiene

Preliminary vibrational analysis of this bicyclic moiety clearly shows the presence of Fermi Resonance phenomena. The alternative to this assignment is shown to be contradictory to both electron diffraction results and to the vibrational data, presented in this paper. Of primary interest is the implications that these spectral results could have for further studies involving classical and non-classical carbonium ion structures.