One-pot Synthesis of 1,8-Dioxo-decahydroacridine Derivatives in Aqueous Media

A new and efficient method for the synthesis of 1,8‐dioxo‐9‐aryl‐decahydroacridine derivatives was developed via a one‐pot three component reaction of dimedone, aromatic aldehydes and ammonium acetate in the presence of ammonium chloride, or Zn(OAc)₂·2H₂O or L‐proline separately in water in the short period of time and high yields.     

2‐(1H‐Benzotriazole‐1‐yl)‐1,1,3,3‐Tetramethyluronium Tetrafluoro Borate (TBTU) as an Efficient Coupling Reagent for the Esterification of Carboxylic acids with Alcohols and Phenols at Room Temperature

Esterification of carboxylic acids with alcohols and phenols by using 2‐(1H‐benzotriazole‐1‐yl)‐1,1,3,3‐tetramethyluronium tetrafluoroborate (TBTU) in the presence of triethylamine as a base proceeded smoothly under mild conditions to afford the corresponding esters in good to high yields in acetonitrile at room temperature.