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Bernd?Lackner Yulita?Popova Christoph?Etzlstorfer Andrija A.?Smelcerovic Christian W.?Klampfl Heinz?FalkEmail author 《Monatshefte für Chemie / Chemical Monthly》2005,136(5):777-793
Summary. The syntheses of the two heterocyclically substituted title hypericin derivatives were achieved starting either from 6-benzothiazolyl-tri-O-methyl-6-demethylemodin or 6-benzoxazolyl-tri-O-methyl-6-demethylemodin. The use of microwave assisted synthesis for the preparation of these anthraquinone synthons and the chemical as well as photochemical properties of the corresponding unique hypericin derivatives, which might constitute new photodynamic therapy agents, are reported. The tautomeric and stereochemical aspects of these hypericin derivatives were investigated by means of semiempirical calculations (AM1). 相似文献
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Admira Bilalic Tina Ticinovic Kurir Marko Kumric Josip A. Borovac Andrija Matetic Daniela Supe-Domic Josko Bozic 《Molecules (Basel, Switzerland)》2021,26(4)
Vascular calcification contributes to the pathogenesis of coronary artery disease while matrix Gla protein (MGP) was recently identified as a potent inhibitor of vascular calcification. MGP fractions, such as dephosphorylated-uncarboxylated MGP (dp-ucMGP), lack post-translational modifications and are less efficient in vascular calcification inhibition. We sought to compare dp-ucMGP levels between patients with acute coronary syndrome (ACS), stratified by ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) status. Physical examination and clinical data, along with plasma dp-ucMGP levels, were obtained from 90 consecutive ACS patients. We observed that levels of dp-ucMGP were significantly higher in patients with NSTEMI compared to STEMI patients (1063.4 ± 518.6 vs. 742.7 ± 166.6 pmol/L, p < 0.001). NSTEMI status and positive family history of cardiovascular diseases were only independent predictors of the highest tertile of dp-ucMGP levels. Among those with NSTEMI, patients at a high risk of in-hospital mortality (adjudicated by GRACE score) had significantly higher levels of dp-ucMGP compared to non-high-risk patients (1417.8 ± 956.8 vs. 984.6 ± 335.0 pmol/L, p = 0.030). Altogether, our findings suggest that higher dp-ucMGP levels likely reflect higher calcification burden in ACS patients and might aid in the identification of NSTEMI patients at increased risk of in-hospital mortality. Furthermore, observed dp-ucMGP levels might reflect differences in atherosclerotic plaque pathobiology between patients with STEMI and NSTEMI. 相似文献
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Andrija Smelcerovic Marc Lamshoeft Niko Radulovic Danijela Ilic Radosav Palic 《Chromatographia》2010,71(1-2):113-116
The chemical composition of the hydro-distilled essential oils of Achillea millefolium and Achillea crithmifolia was analyzed by GC, GC–MS, 13C NMR and high resolution LC–MS. For the first time, the use of the combination of different chromatographic and spectral methods, primarily the advantage of LC-Orbitrap over standard methods, enabled the detection of azulenes and their progenitors, in minute quantities, in previously believed proazulene free Achillea taxon (A. crithmifolia). Furthermore, the LC-Orbitrap hyphenated method provided the means for detection of these and related non-volatile (GC-injector compared to water steam distillation) metabolites up to know unreported as essential oil constituents. 相似文献
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Andrija Raguž 《PAMM》2010,10(1):523-524
We use the approach developed in the paper G. Alberti, S. Muller: A new approach to variational problems with multiple scales, Comm. Pure Appl. Math. 54 , 761-825 (2001) to obtain Γ-convergence for a class of Ginzburg-Landau functionals Iε(v), where v = v(s) is appropriate Sobolev function. We generalize results from the paper A. Raguž: Relaxation of Ginzburg-Landau functional with 1-Lipschitz penalizing term in one dimension by Young measures on micropatterns, Asymptotic Anal. 41 ( 3,4 ), 331-361 (2005), where original functional was penalized by 1-Lipschitz function g = g(s). In this note we prove Γ-convergence when g = g(s, v(s), v′(s)) under suitable growth conditions imposed on g. (© 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
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Kutnjak Z Cordoyiannis G Nounesis G Lebar A Zalar B Zumer S 《The Journal of chemical physics》2005,122(22):224709
A lyotropic inverse micelle phase composed of water, thermotropic liquid-crystal octylcyanobiphenyl (8CB), and surfactant (DDAB) was studied by using high-resolution calorimetry on several mixtures with 3%, 8%, and 15% micelle concentration. Calorimetric results show strong depression of the isotropic to nematic (I-N) phase-transition temperature. Broad heat-capacity anomalies show the existence of a wide coexistence range of isotropic, nematic, and smectic-A phases, which mimics the behavior of a new nearly stable thermodynamic phase. An observation of the rather sharp almost bulklike nematic to smectic-A (N-A) transition at low-temperatures indicates that our heat capacity results are consistent with the phase separation scenario in which significant number of micelles is expelled during I-N conversion leaving almost pure nematic phase at lower temperatures. It was found that micelles get almost completely remixed on heating the mixture back to the isotropic phase. 相似文献
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UV INDUCED DNA-PROTEIN CROSS-LINKS IN VITRO AND IN VIVO 总被引:1,自引:0,他引:1
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G. Stojanovic A. P. Ligon A. Smelcerovic J. Lazarevic M. Spiteller R. Palic 《Chemistry of Natural Compounds》2007,43(4):380-383
For the first time the total acid composition of the seeds of Stachys milanii Petrovic, a species endemic to the central and eastern Balkan Peninsula and growing spontaneously at two localities, was
examined by GC and GC/MS. The major fatty acid was linoleic or oleic acid. Besides fatty acids that represent the usual seed
oil constituents, 6-octadecynoic and 9-oxononanoic acid were identified in considerable amounts. The high content of 6-octadecynoic
acid makes S. milanii seed oil a good potential source for the active substance in antifungal preparations. From the chemotaxonomical point of
view, small amounts of octadecatrienoic acid detected in the seeds suggested classification of S. milanii as an archaic taxon.
Published in Khimiya Prirodnykh Soedinenii, No. 4, pp. 315–317, July–August, 2007. 相似文献