Crystal Structure and Binding Properties of a New Molecular Clip Based on Diethoxycarbonyl Glycoluril： C42H36N6O6

A new molecular clip based on diethoxycarbonyl glycoluril 5: C42H36N6O6 , has been synthesized and characterized by single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group Pbca with a=12.7639(5), b=16.9727(7),c=34.2069(14) , V=7410.5(5)3 , Z=8, Dc=1.292 g/cm3 , μ(MoKα)=0.088 mm-1 , F(000)=3024, the final R=0.0655 and wR=0.1566 for 5123 observed reflections with I>2σ(I). The crystal structural analysis shows that intermolecular c-H…O and C-H…N hydrogen bonds stabilized the whole crystal structure. The binding study by fluorescence spectroscope titration showed that the title molecule can selectively recognize Fe3+ with fluorescence quenching.     

Synthesis,Crystal Structure and Recognition Properties of 2-（5-（4-Chlorophenyl）-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl）pyridine

The title compound 2-(5-(4-chlorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl)- pyridine(C20H16ClN3, Mr = 333.81) has been synthesized and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/n with a = 10.9925(12), b = 11.0378(12), c = 14.2751(18) , β = 98.074(11)°, V = 1714.9(3)3, Z = 4, Dc = 1.293 g/cm3, μ(MoKα) = 0.228 mm-1, F(000) = 696, the final R = 0.0521 and wR = 0.1349 for 3495 observed reflections with I 2σ(I). Intermolecular C–H...π interactions and π-π stacking interactions stabilize the crystal structure. The binding study by fluorescence spectroscope titration showed that the title compound can selectively recognize Fe3+ in THF solution with fluorescence quenching.     

α-(5-氟尿嘧啶-1-基甲基甲酰基)氨基苯丙酸的合成

以5-氟尿嘧啶-1-基乙酸、二环己基碳二酰亚胺和L-苯丙氨酸为原料,1-羟基苯并三氮唑作为辅助试剂,通过碳二亚胺法合成了一种新型的α-(5-氟尿嘧啶-1-基甲基甲酰基)氨基苯丙酸,其结构经IR和元素分析表征.