O~6-甲基鸟嘌呤DNA甲基转移酶与肿瘤化疗的关系

将O~6-甲基鸟嘌呤DNA甲基转移酶(O~6-MT)含量不同的两株人肿瘤细胞植入棵鼠体内,腹腔注射双功能烷化剂(ACNU)治疗,实验结果证明:ACNU对O~6-MT含量低的肿瘤细胞有高特异治疗效果,提示通过临床检验,针对O~6-MT含量低的肿瘤,使用ACNU类抗癌药物,可能开拓一条肿瘤化疗的新途径。     

O~6-METHYLGUANINE-DNA METHYLTRANSFERASE AND HUMAN CANCER CHEMOTHERAPY

Two kinds of human tumor cell strains having different activity of O~6-methylguanine-DNA methyltransferase (O~6-MT) were transplanted into nude mice. Then the mice were inject-ed intraperitoneally with bifunctional alkylating agent 1--(4--amino--2-methyl--5--pyrimidinyl)methy1-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU). The tumors with low O~6-MTactivity were quickly suppressed or cured. The result suggests that some tumors, if previ-sionally determined with low O~6-MT activity, might be efficiently cured by treatment withACNU. This probably opens a new way for human cancer chemotherapy.