重金属离子刺激主动脉平滑肌细胞的增殖

用重金属离子Cd~(2+),Pb~(2+)和Hg~(2+)替代培养液中的Ca~(2+),观察了家兔主动脉平滑肌细胞(ASMC)的增殖与钙调素(CaM)的关系。发现Cd~(2+),Pb~(2+)和Hg~(2+)均不同程度地刺激ASMC的增殖、增加G_1晚期CaM的含量和降低环核苷酸磷酸二酯酶的活性。实验提示重金属毒害可能与动脉粥样硬化和高血压的病因有关。     

THE STIMULATORY EFFECT OF HEAVY METAL CATIONS ON PROLIFERATION OF AORTIC SMOOTH MUSCLE CELLS

Heavy metal cations Cd~(2+), Pb~(2+), and Hg~(2+)were added to substitute for Ca~(2+)in culture media to study their effect on the relationship between CaM and the proliferation of cultured rabbit aortic smooth muscle cells (ASMC). It was found that all the heavy metal cations studied stimulated the proliferation of ASMC in varying degrees, increased the CaM content in cells at late G_1 stage and decreased the activity of cAMP PDE. These results suggest that the adverse effect of heavy metals may be related to the pathogenesis of atherosclerosis and hypertensive disease.